Determinants of Fatigue after First-Ever Ischemic Stroke during Acute Phase

© 2014 The Authors. Published by PLOS. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0110037 A correction to the article was made on 19/12/2012: https://doi.org/10.1371/journal.pone.011646

Role of granulocyte-macrophage colony-stimulating factor on apoptosis induced by ischemia-reperfusion in the intestinal epithelium

Background. To evaluate the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on ischemia-reperfusion-induced apoptosis in the intestinal epithelium. Methods: In this study, 50 male Wistar albino rats were used. After midline laparotomy superior mesenteric artery (SMA) was identified only in the sham group, while 60 min of ischemia and 2 h of reperfusion were performed in the control group. In the treatment groups, after 15, 30 and 60 min of ischemia, respectively, 1 mug/kg GM-CSF was administered subcutaneously, followed by 2 h of reperfusion. Malondialdehyde (MDA), campothecin (CAM), an indicator of DNA fragmentation, and histopathology were evaluated in the intestinal mucosa. Results: Tissue MDA levels were found significantly high in all groups at various times of ischemia and 2 h of reperfusion compared with the sham group (p < 0.001). Administration of GM-CSF following 60 min of ischemia caused a significant increase in the MDA levels compared with the control group (6,430 +/- 725 vs. 4,174 +/- 565 nmol/g protein for jejunum. 7,576 +/- 618 vs. 4,938 +/- 809 nmol/g protein for ileum, p < 0.05). Intestinal ischemia and reperfusion resulted in a significant increase in tissue CAM levels (p < 0.05). The highest CAM value was found in the group in which 60 min of ischemia and 2 h of reperfusion were performed (50 +/- 3.2 ng/ml for jejunum, 52.8 +/- 2.7 ng/mg for ileum). Compared with the control group, GM-CSF administration following 1 h of ischemia aggravated the tissue injury. Conclusions: Apoptosis was induced in the small intestine by ischemia-reperfusion. GM-CSF increased the apoptosis of intestinal epithelial cells and exacerbated mucosal injury due to ischemia-reperfusion. Copyright (C) 2003 S. Karger AG, Basel

A Prediction Model for Fault Detection in Molding Process Based on Logistic Regression Technique

19th International Symposium for Production Research, ISPR 2019 -- 28 August 2019 through 30 August 2019 -- -- 233539Industry 4.0 is often described as a wave of transformation that enforces the digitalization of processes to create integrated and autonomous systems. In this regard, the collection of process data is a necessity to analyze data with advanced techniques for various purposes. Statistical techniques in machine learning might provide solutions for fault detection and other tasks in manufacturing processes. In our study, a learning model is proposed for a fault prediction task with the use of Logistic Regression. The data used for the analysis involve measurements from sequential processes carried out in a large-scale wheel rim manufacturer. The pre-processing and analysis of process data was introduced along with a case study. Moreover, findings of the model were presented and the potential use of the model will be discussed. © 2020, Springer Nature Switzerland AG.We would like to thank Maxion ?nci Wheel Group and Logo Business Solutions for their support and contribution in this study

Quantitative Analysis of Stakeholder Perspective on the University-Industry-Government Collaboration in İzmir, Turkey

International Symposium for Production Research, ISPR 2020 -- 24 September 2020 through 26 September 2020 -- -- 250869Industry 4.0 necessitates the transformation of businesses towards the use of digital technologies and become more competitive in a global market. The collaboration of businesses and academic institutions is a fundamental enabler to achieve innovation. The models, such as Triple Helix, emphasize this collaboration and have increasingly received a great deal of attention from government policies in Turkey. With this perspective, a workshop hosted by the Aegean Region Chamber of Industry has been organized with the participation of representatives from universities, industry, and public institutions. This study presents our findings obtained through the workshop and aims to propose insights for policymakers. In particular, our survey data consists of indicators that were organized into three focal themes: collaboration, digitalization, and innovation. The survey data have been clustered based on participants’ ranking on the indicators using the k-means technique. © 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG

A Customized Web-Based Training Platform for Industry 4.0

22nd International Symposium for Production Research, ISPR 2022 -- 6 October 2022 through 8 October 2022 -- 291539The Industry 4.0 revolution paves the way for a radical transformation in production systems. This transformation also necessitates acquiring the required skills to accomplish new tasks and job descriptions. On the other hand, individuals have different skills, learning preferences, and requirements. In this sense, designing training programmes for Industry 4.0 requires considering the gap between job requirements and learners, individually. This study presents a customized web-based training platform developed as a part of CEPI 4.0 Project. The platform incorporates training modules developed as a result of need analyses conducted in Turkey, Austria, Slovakia, and Romania. The competency gap of an individual is determined through an initial assessment. Then, each individual is presented a customized set of contents from the Industry 4.0 training modules, which have been prepared through our project. Finally, the individual or group-level progress achieved through customized training is demonstrated using an Industry 4.0 Education Scale developed for the project. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.Acknowledgment. This study presents the final research output obtained through the CEPI 4.0 project (A Customized Education Plan Based on Industry 4.0 Competency Gaps. Project-Identifier: 2019–1-TR01-KA202–077366) funded by the EU Commission within the ERASMUS+ Programme (KA202 - Strategic Partnership for Vocational Education and Training).European Commission, EC: KA20

Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70

Background. Reperfusion of the liver after ischemia induces the expression of the heat shock genes and the synthesis of the heat shock proteins (HSP). We studied the effects of the natural antioxidant ergothioneine (EGT) treatment on the expression of HSP70 in ischemic-reperfused (IR) liver