The complex concept of sustainable of diversity management:…and why forming policies in this area is far from straightforward

Purpose – Explores the notion of sustainable diversity-management practices. Design/methodology/approach – Summarizes research into the sustainability of diversity management across four countries and provides examples of efforts to maintain high levels of diversity. Findings – Looks at the activities of Africa House, an organization that develops business links with Africa, and of BEN Television, which is a television station that caters primarily for ethnic minorities. Practical implications – Demonstrates that diversity is a multi-dimensional concept that can be structured within two frameworks: demographic diversity regarding, for example, age, gender and nationality; and human-capital diversity, such as cognitive diversity, skill and experience diversity. Social implications – Highlights the complexity of diversity and so the difficulty of legislating in this area. Originality/value – Explains that employees can also stifle attempts to engage in sustainable diversity management policies. A lack of understanding of local laws or language, or through limited social contacts, can prevent full participation by employees

Perspective: Sustaining the economic competitiveness of Nigeria\'s Food Basket - the case for effective deregulation of the downstream petroleum industry

In view of the apparent acceptability of the proposed Financial Strategy 2020, there is need for the issue of fuel subsidy to be confronted and resolved definitively, in order for the overall energy and national economic development funding to be matched by internally generated resources. NESG Economic Indicators Vol. 13 (4) 2007 pp. 62-6

Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists

Pre-clinical characterization of novel substituted pyrrolidines that are high affinity histamine H3 receptor antagonists is described. These compounds efficiently penetrate the CNS and occupy the histamine H3 receptor in rat brain following oral administration. One compound, (2S,4R)-1-[2-(4-cyclobutyl-[1,4]diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-yl]-ethanone, was extensively profiled and shows promise as a potential clinical candidate

Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑<i>a</i>]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

Novel 5,6-dihydro-[1,2,4]­triazolo­[4,3-<i>a</i>]­pyrazine P2X7 antagonists were optimized to allow for good blood-brain barrier permeability and high P2X7 target engagement in the brain of rats. Compound <b>25</b> (huP2X7 IC₅₀ = 9 nM; rat P2X7 IC₅₀ = 42 nM) achieved 80% receptor occupancy for 6 h when dosed orally at 10 mg/kg in rats as measured by ex vivo radioligand binding autoradiography. Structure–activity relationships within this series are described, as well as in vitro ADME results. In vivo pharmacokinetic data for key compounds is also included