A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+T cell responses

Enterotoxigenic Escherichia coli (ETEC) are a common cause of diarrheal illness in young children and travelers. There is yet no licensed broadly protective vaccine against ETEC. One promising vaccine development strategy is to target strains expressing the heat-stable toxin (ST), particularly the human ST (STh), since infections with these strains are among the leading causes of diarrhea in children in low-and-middle income countries. A human challenge model based on an STh-only ETEC strain will be useful to evaluate the protective efficacy of new ST-based vaccine candidates. To develop this model, we experimentally infected 21 healthy adult volunteers with the epidemiologically relevant STh-only ETEC strain TW10722, identified a suitable dose, assessed safety, and characterized clinical outcomes and immune responses caused by the infection. Doses of 1x10(10) colony-forming units (CFU) of TW10722 gave a suitable attack risk of 67% for moderate or severe diarrhea and an overall diarrhea attack risk of 78%. Non-diarrheal symptoms were mostly mild or moderate, and there were no serious adverse events. During the first month after ingesting the challenge strain, we measured significant increases in both activated CD4+ T cells and levels of serum IgG and IgA antibodies targeting coli surface antigen 5 (CS5) and 6 (CS6), as well as the E. coli mucinase YghJ. The CS5-specific CD4+ T cell and antibody responses were still significantly elevated one year after experimental infection. In conclusion, we have developed a safe STh-only ETEC-based human challenge model which can be efficiently used in Phase 2B trials to evaluate the protective efficacy of new ST-based vaccine candidates

“Es fundamental que la información que se transmita sea confiable”

El flamante Doctor Honoris Causa de la UNLP, Emilio Luque Fadón, de la Universidad Autónoma de Barcelona, fue uno de los conferencistas de CACIC 2017. Durante su estadía por la ciudad de La Plata, el español habló acerca de las nuevas tecnologías, su tolerancia a los fallos y el consumo energético.Facultad de Informátic

Body projects and the regulation of normative masculinity

Drawing on interviews with 140 young British males, this paper explores the ways in which men talk about their own bodies and bodily practices, and those of other men. The specific focus of interest is a variety of body modification practices, including working out (at a gym) tattooing, piercing and cosmetic surgery. We want to argue, however, that the significance of this analysis extends beyond the topic of body modification to a broader set of issues concerned with the nature of men’s embodied identities. In discussing the appearance of their bodies, the men we interviewed talked less about muscle and skin than about their own selves located within particular social, cultural and moral universes. The surfaces of their bodies were, as Mike Featherstone (1991) has argued, charged primarily with ‘identity functions’, allowing men to establish a place for themselves in contemporary society. Using a social psychological approach which can be characterised as a discursive analysis (Henwood, Gill & McLean, 1999; Lupton, 1998), this paper makes connections between men’s private feelings and bodily practices, and broader social and cultural trends and relations. It shows that in talking about seemingly trivial questions such as whether to have one’s nose pierced or whether to join a gym, men are actively engaged in constructing and policing appropriate masculine behaviours and identities; above all, in regulating normative masculinity. We identify five key discourses or ‘interpretive repertoires’ (Wetherell & Potter, 1992) which together construct the meanings for these men of attempts to modify the appearance of the body. The five discourses or repertoires were focused on the themes of individualism and ‘being different’; libertarianism and the autonomous body; unselfconsciousness and the rejection of vanity; a notion of the ‘well-balanced’ and unobsessional self; and self-respect and the morally accountable body. Our analysis lends support to the claim that the body has become a new (identity) project in high/late/postmodernity (e.g. Shilling, 1993; Featherstone, 1991), but shows how fraught with difficulties this project is for young men who must simultaneously work on and discipline their bodies while disavowing any (inappropriate) interest in their own appearance. The analysis highlights the pervasive individualism of young men’s discourses, and the absence of alternative ways of making sense of embodied experiences