Post cesarean pregnancy and its outcome

Background: Though in recent years lower segment cesarian section (LSCS) procedure is the major reason for the reduction in the mortality rate for both mother and baby, inappropriate indications may affect the outcome of pregnancy. Thus, this study was done with the aim of assessing the prevalence of outcome of delivery among women who underwent caesarean section (CS) and to assess the factors associated with that outcome.Methods: This study was conducted with a sample of 98 pregnant mothers. After acquiring informed consent, those mothers who were indicated for CS (both elective and emergency) were enquired about the questionnaire containing two parts. Part one is about the history regarding previous birth and the next part is about age, parity, and outcome of current pregnancy (both mother and baby).Results: The mean age of the study participants is 27 years. Among the study participants, about half of them (51%) were in gravida one and 37 percent have one abortion. About four-fifths of the study participants (81%) were undergone elective LSCS. About one-fourth of the baby needs neonatal intensive care unit (NICU) admission and two percent have the complication of neonatal sepsis. The factors significantly associated with NICU admission of babies delivered after LSCS are more number of the previous history of abortions (p=0.004) and emergency LSCS (p=0.001) by using the chi-square test.Conclusions:  The indication of previous LSCS for LSCS among pregnant mothers is in a rising trend that needs holistic commitment to reduce the prevalence of LSCS.

Association of hyperlipidemia in preterm delivery

Background: There are 3.6 million/year neonatal deaths around the world, of which 99 percent deaths are contributed by the developing countries. An infant born before 37 completed weeks is called as preterm. Normal human pregnancy results in a pronounced physiological hypertriglyceridemia involving a gestational rise in blood triglycerides (TGL) and cholesterol.  As elevated circulating levels of triglycerides and cholesterol are markers for increased risk of preterm labor in pregnant women. Atherosis of the Utero placental spiral arteries may be induced by the Hyperlipidemia in pregnancy to cause preterm delivery.Methods: The study group included 444 healthy pregnant women in the age group of 17-35 years and whose gestational age was confirmed either by their last menstrual period or by dating ultrasound. This study was conducted to evaluate the association of elevated serum triglycerides and cholesterol levels, in an uncomplicated pregnancy and preterm delivery. In all these antenatal mothers (study group) a detailed history with special reference to diet and habits, followed by a complete obstetric and general examination were done. All antenatal mothers who were included in the study were subjected for serum triglycerides and cholesterol estimation from the overnight fasting blood samples, at 24, 28, & 32 weeks of gestation.Results: In this study 374 patients who had normal cholesterol delivered at term, however 15 patients out of 26 (42.5%) patients who showed abnormal cholesterol had preterm delivery and 22 patients out of 35 (62.8%) patients with abnormal triglycerides level delivered prematurely.Conclusions: The measurement of serum total cholesterol and triglycerides along with other measures like clinical and serum screening of Alpha fetoprotein and inhibin A can potentially be used for predicting the preterm labo

3-WAY Secured WSN with CSDSM-DNN based Intrusion Detection Model

In Wireless Sensor Networks (WSNs), intrusion aims indegrading or even eliminating the capacity of these networks for providing their functions. Thus, in recent years, several ideas are brought and employed. However, these techniques still did not fulfill their requirements in attaining better classification accuracy. This paper proposes a novel Cosine Similarity Distance integrated Sammon Mapping learning layer-Deep Neural Network (CSDSM-DNN)-centricIntrusion Detection Model (IDM) in WSNfor attaining better outcomes. Initially, the nodes are clustered; after that, utilizing Binomial Distribution based Dwarf Mongoose Optimization (BD-DMO), the cluster heads are selected. Then, theIdentity Matrix Function-Kalman Filter (IMF-KF) identified the optimal route. Subsequently, the data is transferred via the secured route. The transferred data is pre-processed and then, the important features are selected. Lastly, to classify whether the data is attacked or non-attacked, the selected features are given into the CSDSM-DNN. Therefore, with the prevailing approaches, the experiential outcomes are evaluated and analogized and it exhibits the proposed model’s higher reliability and efficacy

Exploring the Antimicrobial Potential of Phyllanthus emblica L. (Amla) using Molecular Docking Studies against Shrimp Pathogens

Vibriosis is a major problem in shrimp farm. Farmers indiscriminately use hormones, antibiotics, disinfectants and other chemicals in fish feed and culture water to protect their crops. E. coli and Aeromonas sp were highly predominant isolates. Herbs act as agents in aquaculture to control or reduce pathogen infections. The results of phytochemicals screening of fruit extract of Phyllanthus emblica showed the presence of various phytchemicals. Phyllanthus emblica extract shows anti-bacterial properties against biofilm producing shrimp pathogens. Among the 10 bacterial genera, E. coli and P.aeruginosa were highly suppressed. The extracts exhibited the bacteria growth inhibitory activity in a dose-dependent manner. The compound sitosterol has potent antibiofilm activity was showed by molecular docking, which revealed a significant binding energy and interaction (-8.4 Kcal/mol) between it and key biofilm-forming protein. Diving analysis was done using the chemical compounds found in GCMS analysis

Preparation and Characterization of Silver Nanoparticle/Aloe Vera Incorporated PCL/PEO matrix for wound dressing application

Polymeric wound dressing materials have remarkable mechanical, structural, and biocompatible behavior. In this work, a polymer matrix of Polycaprolactone (PCL)/Polyethylene Oxide (PEO) incorporated with Aloe Vera (AV) extract and silver nanoparticles were prepared for wound dressing application. Initially, the phytochemicals from AV were extracted by Soxhlet apparatus, and then the aloe extract was used as a reducing agent to synthesize silver nanoparticles (Ag NP). Ag NP's formation was confirmed by the presence of a characteristic UV absorbance peak at 420 nm. Ag NP's average diameter and shape were found to be between 10-50 nm and spherical, respectively. AV extract and Ag NP were incorporated into PCL/PEO polymer solution to prepare the polymer matrix by solution casting method. Box-Behnken design (BBD) was used to study the effect of Ag NP concentration, AV extract percentage, and PEO weight percentage concerning PCL on wound dressing application. Water Vapor Transmission Rate (WVTR) and swelling properties of all the sample were tested and found that the PEO and AV extract plays a major role in both swelling and WVTR irrespective of Ag NP concentration. The antimicrobial property of synthesized Ag NP was studied against gram-negative bacteria Escherichia coli with control samples (PCL and PCL/PEO), Ag NP with 150 mg concentration showed a higher zone of inhibition than the other concentrations. Thus, the prepared PCL/PEO polymer matrix incorporated with AV extract and Ag NP can be used as an effective wound dressing material

Preparation and Characterization of Silver Nanoparticle/Aloe Vera Incorporated PCL/PEO matrix for wound dressing application

35-44Polymeric wound dressing materials have remarkable mechanical, structural, and biocompatible behavior. In this work, a polymer matrix of Polycaprolactone (PCL)/Polyethylene Oxide (PEO) incorporated with Aloe Vera (AV) extract and silver nanoparticles were prepared for wound dressing application. Initially, the phytochemicals from AV were extracted by Soxhlet apparatus, and then the aloe extract was used as a reducing agent to synthesize silver nanoparticles (Ag NP). Ag NP's formation was confirmed by the presence of a characteristic UV absorbance peak at 420 nm. Ag NP's average diameter and shape were found to be between 10-50 nm and spherical, respectively. AV extract and Ag NP were incorporated into PCL/PEO polymer solution to prepare the polymer matrix by solution casting method. Box-Behnken design (BBD) was used to study the effect of Ag NP concentration, AV extract percentage, and PEO weight percentage concerning PCL on wound dressing application. Water Vapor Transmission Rate (WVTR) and swelling properties of all the sample were tested and found that the PEO and AV extract plays a major role in both swelling and WVTR irrespective of Ag NP concentration. The antimicrobial property of synthesized Ag NP was studied against gram-negative bacteria Escherichia coli with control samples (PCL and PCL/PEO), Ag NP with 150 mg concentration showed a higher zone of inhibition than the other concentrations. Thus, the prepared PCL/PEO polymer matrix incorporated with AV extract and Ag NP can be used as an effective wound dressing material

Estimating the birth prevalence and pregnancy outcomes of congenital malformations worldwide

Congenital anomaly registries have two main surveillance aims: firstly to define baseline epidemiology of important congenital anomalies to facilitate programme, policy and resource planning, and secondly to identify clusters of cases and any other epidemiological changes that could give early warning of environmental or infectious hazards. However, setting up a sustainable registry and surveillance system is resource-intensive requiring national infrastructure for recording all cases and diagnostic facilities to identify those malformations that that are not externally visible. Consequently, not all countries have yet established robust surveillance systems. For these countries, methods are needed to generate estimates of prevalence of these disorders which can act as a starting point for assessing disease burden and service implications. Here, we describe how registry data from high-income settings can be used for generating reference rates that can be used as provisional estimates for countries with little or no observational data on non-syndromic congenital malformations

Modeling and Analysis of MHD Free Convective Thermo-Solutal Transport in Casson Fluid Flow with Radiative Heat Flux

This research paper presents a novel mathematical model aimed at exploring practical applications in oscillating MHD generators and near-wall flows using Casson fluid. The purpose of this study is to develop a mathematical model that specifically addresses MHD free convective thermo-solutal transport within Casson fluid flow over a rotating vertical wall into a permeable medium. This research also considers factors like the Soret effect, radiative heat flux, first-order chemical reactions, and heat source/sink effects. To tackle this complex scenario, we apply the Laplace transform technique (LTT) to handle the transformed partial differential equations and their accompanying boundary conditions. The study investigated both ramped and isothermal wall temperature conditions and evaluated the influence of various parameters, including the Soret number, Hall current parameter, ramped wall temperature, and magnetic body force parameter. The computational analysis is carried out using MATLAB software. The research involves a comprehensive parametric analysis that thoroughly examines the impact of key emerging parameters on generalized velocity, temperature, and species concentration. The results reveal that magnetic, Casson, and rotating parameters all have a diminishing impact on the velocity profiles. The radiation parameter has a positive impact on temperature distribution, while an opposite trend is observed for the Prandtl number. Furthermore, an increase in the Soret number and chemical reaction parameter leads to a decrease in species concentration and solutal boundary layer thickness. The validation process includes comparisons with previous studies. Additionally, this study presents distributions of skin friction, Nusselt number, and Sherwood number. Notably, our findings 1 reveal that a ramped wall temperature results in lower velocity magnitudes compared to the isothermal wall case