Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever

AbstractSalmonella spp. are Gram-negative, facultative, intracellular pathogens that cause several diarrheal diseases ranging from self-limiting gastroenteritis to typhoid fever. Previous results from our laboratory showed that Saccharomyces cerevisiae strain UFMG 905 isolated from ‘cachaça’ production presented probiotic properties due to its ability to protect against experimental infection with Salmonella enterica serovar Typhimurium. In this study, the effects of oral treatment with S. cerevisiae 905 were evaluated at the immunological level in a murine model of typhoid fever. Treatment with S. cerevisiae 905 inhibited weight loss and increased survival rate after Salmonella challenge. Immunological data demonstrated that S. cerevisiae 905 decreased levels of proinflammatory cytokines and modulated the activation of mitogen-activated protein kinases (p38 and JNK, but not ERK1/2), NF-κB and AP-1, signaling pathways which are involved in the transcriptional activation of proinflammatory mediators. Experiments in germ-free mice revealed that probiotic effects were due, at least in part, to the binding of Salmonella to the yeast. In conclusion, S. cerevisiae 905 acts as a potential new biotherapy against S. Typhimurium infection due to its ability to bind bacteria and modulate signaling pathways involved in the activation of inflammation in a murine model of typhoid fever

Indicação da cultivar de soja BRS Raimunda para Goiás e Distrito Federal.

ABSTRACT: The soybean cultivar BRS Raimunda is a result a Group Work formed by researcher of Embrapa Cerardos in conjunction with Embrapa Soja, with significant finantial support of Cerrados Fundation. In term of genealogy BRS Raimunda originated of a cross between Braxton X BR93-31857 and it was developed by modified genealogical and method of plant breeding. In the final research tests for variety release to the farms, the cultivars BRS Raimunda was superior in terms of grain production than the cultivars tests such as M-SOY 8800, DM 339 and Uirapuru. BRS Raimunda is a late cultivar indicated to the Cerrado Biome of Goias State and Federal District. Besides the high productivity and stability, the cultivar presents also resistence to the root-knot such as Meloidogyne incognita and Meloidogyne javanica.bitstream/CPAC-2009/26194/1/comtec_106.pd

Genomics and epidemiology for gastric adenocarcinomas (GE4GAC): a Brazilian initiative to study gastric cancer

Abstract Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings