4 research outputs found
Improvement of Epitope Prediction Using Peptide Sequence Descriptors and Machine Learning
[Abstract] In this work, we improved a previous model used for the prediction of proteomes as new
B-cell epitopes in vaccine design. The predicted epitope activity of a queried peptide is based on its
sequence, a known reference epitope sequence under specific experimental conditions. The peptide
sequences were transformed into molecular descriptors of sequence recurrence networks and were
mixed under experimental conditions. The new models were generated using 709,100 instances of pair
descriptors for query and reference peptide sequences. Using perturbations of the initial descriptors
under sequence or assay conditions, 10 transformed features were used as inputs for seven Machine
Learning methods. The best model was obtained with random forest classifiers with an Area Under
the Receiver Operating Characteristics (AUROC) of 0.981 ± 0.0005 for the external validation series
(five-fold cross-validation). The database included information about 83,683 peptides sequences,
1448 epitope organisms, 323 host organisms, 15 types of in vivo processes, 28 experimental techniques,
and 505 adjuvant additives. The current model could improve the in silico predictions of epitopes for
vaccine design. The script and results are available as a free repositor
LECTINPred: web server that uses complex networks of protein structure for prediction of lectins with potential use as cancer biomarkers or in parasite vaccine design
Ministerio de Ciencia e Innovación; AGL2010-22290-C03-01Ministerio de Ciencia e Innovación; AGL2011-30563-C03-0
Optimal and Long-Term Dynamic Transport Policy Design: Seeking Maximum Social Welfare through a Pricing Scheme.
This article presents an alternative approach to the decision-making process in transport strategy design. The study explores the possibility of integrating forecasting,
assessment and optimization procedures in support of a decision-making process designed to reach the best achievable scenario through mobility policies.
Long-term evaluation, as required by a dynamic system such as a city, is provided by a strategic Land-Use and Transport Interaction (LUTI) model. The social welfare
achieved by implementing mobility LUTI model policies is measured through a cost-benefit analysis and maximized through an optimization process throughout the evaluation period. The method is tested by optimizing a pricing policy scheme in Madrid on a cordon toll in a context requiring system efficiency, social equity and environmental quality. The optimized scheme yields an appreciable increase in social surplus through a relatively low rate compared to other similar pricing toll schemes. The results highlight the different considerations regarding mobility impacts on the case study area, as well as the major contributors to social welfare surplus. This leads the authors to reconsider the cost-analysis approach, as defined in the study, as the best option for formulating sustainability measures