A review of data on abundance, trends in abundance, habitat use and diet of ice-breeding seals in the Southern Ocean

The development of models of marine ecosystems in the Southern Ocean is becoming increasingly important as a means of understanding and managing impacts such as exploitation and climate change. Collating data from disparate sources, and understanding biases or uncertainties inherent in those data, are important first steps for improving ecosystem models. This review focuses on seals that breed in ice habitats of the Southern Ocean (i.e. crabeater seal, Lobodon carcinophaga; Ross seal, Ommatophoca rossii; leopard seal, Hydrurga leptonyx; and Weddell seal, Leptonychotes weddellii). Data on populations (abundance and trends in abundance), distribution and habitat use (movement, key habitat and environmental features) and foraging (diet) are summarised, and potential biases and uncertainties inherent in those data are identified and discussed. Spatial and temporal gaps in knowledge of the populations, habitats and diet of each species are also identified

Applying the theory of planned behavior : Examining how communication, attitudes, social norms, and perceived behavioral control relate to healthy lifestyle intention in Singapore

This study investigates the extent to which communication variables, namely, interpersonal communication and attention to mass media, as well as the key components in the theory of planned behavior (TPB), including, attitudes, social norms, and perceived behavioral control, are associated with healthy lifestyle intention in Singapore. Healthy lifestyle intention was conceptualized and operationalized in terms of individuals’ proclivity for physical activity and healthy diet. Data came from a nationally representative computer-assisted telephone interview (CATI) of 1,055 Singaporeans aged 21 years and above . Hierarchical regression analysis was conducted. Results show that both communication and planned behavior variables were positively related to behavioral intention. The study is important for both theory and practice. Theoretically, it demonstrates the possibility to extend the TPB with two more variables: interpersonal communication and attention to mass media. On the practical front, the results inform health authorities and marketers on ways to promote public adoption of healthy lifestyle in Singapore

T Pyxidis: The First Cataclysmic Variable with a Collimated Jet

We present the first observational evidence for a collimated jet in a cataclysmic variable system; the recurrent nova T Pyxidis. Optical spectra show bipolar components of H$\alpha$ with velocities $\sim 1400 km/s$, very similar to those observed in the supersoft X-ray sources and in SS 433. We argue that a key ingredient of the formation of jets in the supersoft X-ray sources and T Pyx (in addition to an accretion disk threaded by a vertical magnetic field), is the presence of nuclear burning on the surface of the white dwarf.Comment: 10 pages 2 figures to appear in ApJ Letter

Perturbation with Intrabodies Reveals That Calpain Cleavage Is Required for Degradation of Huntingtin Exon 1

Background: Proteolytic processing of mutant huntingtin (mHtt), the protein that causes Huntington's disease (HD), is critical for mHtt toxicity and disease progression. mHtt contains several caspase and calpain cleavage sites that generate N-terminal fragments that are more toxic than full-length mHtt. Further processing is then required for the degradation of these fragments, which in turn, reduces toxicity. This unknown, secondary degradative process represents a promising therapeutic target for HD. Methodology/Principal Findings: We have used intrabodies, intracellularly expressed antibody fragments, to gain insight into the mechanism of mutant huntingtin exon 1 (mHDx-1) clearance. Happ1, an intrabody recognizing the proline-rich region of mHDx-1, reduces the level of soluble mHDx-1 by increasing clearance. While proteasome and macroautophagy inhibitors reduce turnover of mHDx-1, Happ1 is still able to reduce mHDx-1 under these conditions, indicating Happ1-accelerated mHDx-1 clearance does not rely on these processes. In contrast, a calpain inhibitor or an inhibitor of lysosomal pH block Happ1-mediated acceleration of mHDx-1 clearance. These results suggest that mHDx-1 is cleaved by calpain, likely followed by lysosomal degradation and this process regulates the turnover rate of mHDx-1. Sequence analysis identifies amino acid (AA) 15 as a potential calpain cleavage site. Calpain cleavage of recombinant mHDx-1 in vitro yields fragments of sizes corresponding to this prediction. Moreover, when the site is blocked by binding of another intrabody, V_L12.3, turnover of soluble mHDx-1 in living cells is blocked. Conclusions/Significance: These results indicate that calpain-mediated removal of the 15 N-terminal AAs is required for the degradation of mHDx-1, a finding that may have therapeutic implications

Assisted stellar suicide in V617 Sgr

V617 Sgr is a V Sagittae star - a group of binaries thought to be the galactic counterparts of the Compact Binary Supersoft X-ray Sources - CBSS. To check this hypothesis, we measured the time derivative of its orbital period. Observed timings of eclipse minima spanning over 30,000 orbital cycles are presented. We found that the orbital period evolves quite rapidly: P/Pdot = 1.1 x 10^{6} years. This is consistent with the idea that V617 Sgr is a wind driven accretion supersoft source. As the binary system evolves with a time-scale of about one million years, which is extremely short for a low mass evolved binary, it is likely that the system will soon end either by having its secondary completely evaporated or by the primary exploding as a supernova of type Ia.Comment: 4 pages, accepted for publication in A&A Letter

ORFEUS II Far-UV Spectroscopy of AM Herculis

Six high-resolution (\lambda/\Delta\lambda ~ 3000) far-UV (\lambda\lambda = 910-1210 \AA) spectra of the magnetic cataclysmic variable AM Herculis were acquired in 1996 November during the flight of the ORFEUS-SPAS II mission. AM Her was in a high optical state at the time of the observations, and the spectra reveal emission lines of O VI \lambda\lambda 1032, 1038, C III \lambda 977, \lambda 1176, and He II \lambda 1085 superposed on a nearly flat continuum. Continuum flux variations can be described as per Gansicke et al. by a ~ 20 kK white dwarf with a ~ 37 kK hot spot covering a fraction f~0.15 of the surface of the white dwarf, but we caution that the expected Lyman absorption lines are not detected. The O VI emission lines have narrow and broad component structure similar to that of the optical emission lines, with radial velocities consistent with an origin in the irradiated face of the secondary and the accretion funnel, respectively. The density of the narrow- and broad-line regions is n_{nlr} ~ 3\times 10^{10} cm^{-3} and n_{blr} ~ 1\times 10^{12} cm^{-3}, respectively, yet the narrow-line region is optically thick in the O VI line and the broad-line region is optically thin; apparently, the velocity shear in the broad-line region allows the O VI photons to escape, rendering the gas effectively optically thin. Unexplained are the orbital phase variations of the emission-line fluxes.Comment: 15 pages, 6 Postscript figures; LaTeX format, uses aaspp4.sty; table2.tex included separately because it must be printed sideways - see instructions in the file; accepted on April 17, 1998 for publication in The Astrophysical Journa

Kaleidoscope laser

We report the first calculations of mode patterns of unstable-cavity lasers with truly two-dimensional transverse geometries. A detailed account of numerical techniques, incorporating a nonorthogonal beam-propagation method, and results for cavities with a range of transverse symmetries, such as regular polygonal and rhomboid, are presented. In view of the beautiful complexity of the eigenmodes predicted, a novel kaleidoscope laser is proposed

Optimizing omnidirectional reflection by multilayer mirrors

Periodic layered media can reflect strongly for all incident angles and polarizations in a given frequency range. Quarter-wave stacks at normal incidence are commonplace in the design of such omnidirectional reflectors. We discuss alternative design criteria to optimize these systems.Comment: 9 pages, 6 figures. To be published in J. Opt. A: Pure and Applied Optic