DESAFIOS E APRENDIZADOS DAS AÇÕES DE EDUCAÇÃO AMBIENTAL NA OCUPAÇÃO VISTA ALEGRE DO JUÁ, SANTARÉM, PARÁ

O recorrente aumento das zonas urbanas e a redução das áreas arborizadas acarretam baixa qualidade aos ambientes de convivência social. A educação ambiental entra como ferramenta auxiliadora de criação e manutenção dessas áreas. Com objetivo de contribuir para a qualidade ambiental em uma zona de ocupação irregular no município de Santarém, Pará, desenvolveu-se um trabalho de arborização, atrelando ações educativas, associando preservação e educação. Procedeu-se com a atividades de produção de mudas e plantio de espécies arbóreas, junto a práticas educacionais voltadas a educação ambiental, como discussão de temáticas ambientais. Foram desenvolvidas atividades de contação de histórias, construção de maquetes e desenhos, além de práticas de produção de mudas, compostagem, plantio e cuidados com as espécies arbóreas. Ocorreu contribuição significativa para com as crianças e jovens, na formação de uma consciência crítica, incentivando-as a agir de maneira mais ativa dentro do contexto abordado. Palavras-chave: Educação ambiental; produção de mudas; compostagem; consciência ecológica

Depletion of neutrophils did not improve the metabolic alterations in antigen-induced arthritis mice.

<p>(A) Intensity of nociception. Inflammation in the knee cavity represented by (B) number of neutrophils and (C) myeloperoxidase activity. Metabolic features represented by (D) glucose, (E) triglyceride and total cholesterol levels, accompanied by the adipocytokines (F) adiponectin and leptin levels in the serum. (G) The PTX3 of mice that received an intra-articular injection in the knee cavity of PBS, mBSA or mBSA treated prior with RB6-8C5. The bars represent the mean values±SEM (n = 4–6), *<i>P</i><0.05 vs. PBS; #<i>P</i><0.05 vs. AIA of the respective time.</p

Pre-treatment with Etanercept improves the altered metabolic parameters of antigen-induced arthritis mice.

<p>(A) Intensity of nociception. (B) Neutrophils, (C) myeloperoxidase activity, (D) CXCL1 chemokine in the peri-articular tissue and (E) arthritis index. Systemic glucose metabolism showed by (F) glucose levels, (G) HOMA-IR index and (H) oral glucose tolerance test. The lipids, (I) triglyceride and total cholesterol levels. The adipocytokines, (J) adiponectin and leptin levels. (K) PTX3 levels of mice that received a knee intra-articular injection of PBS, mBSA or mBSA treated prior with Etanercept. Bars represent the mean values ±SEM (n = 6–8), *<i>P</i><0.05 vs. PBS; #<i>P</i><0.05 vs. AIA of the respective time.</p

Antigen-induced arthritis in mice is mainly associated with the presence of neutrophils.

<p>(A) Intensity of nociception. (B) Number of neutrophils, (C) myeloperoxidase activity, and (D) CXCL1 chemokine levels in the peri-articular tissue. (E) Representative photos of the morphologic alterations in the knee (x100 and x400) and (F) arthritis index. Arrows indicate the synovial and asterisks represent the inflammatory infiltrate. Adipose tissue and liver (G) myeloperoxidase activity, and (H) CXCL1 levels at 1, 3, 24 and 48 hours after the challenge with the antigen-induced arthritis (AIA). Bars represent the mean values±SEM (n = 6–8). Neutrophils number in (I) epididymal adipose tissue and liver accumulated in Lysm-eGFP mice and (J) representative confocal microscopy image, 3 and 24 hours after the challenge with the AIA (x100). Bars represent the mean values±SEM (n = 3–5), *<i>P</i><0.05 vs. PBS.</p

Pre-treatment with DF2156A contributes to metabolic alterations in antigen-induced arthritis mice.

<p>(A) Intensity of nociception. (B) Number of neutrophils, (C) myeloperoxidase activity, (D) CXCL1 chemokine in the peri-articular tissue and (E) arthritis index. Systemic glucose metabolism showed by (F) glucose levels, (G) HOMA-IR index and (H) oral glucose tolerance test. The lipids, (I) triglyceride and total cholesterol levels. The adipocytokines, (J) adiponectin and leptin levels. (K) PTX3 levels of mice that received a knee intra-articular injection of PBS, mBSA or mBSA treated prior with DF2156A. Bars represent the mean values±SEM (n = 6–8), *<i>P</i><0.05 vs. PBS; #<i>P</i><0.05 vs. AIA of the respective time.</p

Systemic metabolic alterations in antigen-induced arthritis mice at different time points.

<p>The metabolism of glucose showed by (A) glucose levels, (B) HOMA-IR index and (C) oral glucose tolerance test. The lipid metabolism represented by (D) triglyceride and (E) total cholesterol levels. Serum levels of the adipocytokines, (F) adiponectin and (G) leptin at 1, 3, 24 and 48 hours after the challenge with the antigen-induced arthritis (AIA). The bars represent the mean values ± SEM (n = 6–8), *<i>P</i><0.05 vs. PBS.</p