39 research outputs found
Disease free survival (DFS) as a surrogate for Overall Survival (OS) in Localized Prostate Cancer (CaP) - Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) Working Group
Disease-free survival (DFS) as a surrogate for overall survival (OS) in localized prostate cancer (CaP)
Comprehensive splicing functional analysis of DNA variants of the BRCA2 gene by hybrid minigenes
A review of a decade of lessons from one of the world’s largest MPAs: conservation gains and key challenges
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordtribute to global conservation targets, we review outcomes of the last decade of marine conservation research in the British
Indian Ocean Territory (BIOT), one of the largest MPAs in the world. The BIOT MPA consists of the atolls of the Chagos
Archipelago, interspersed with and surrounded by deep oceanic waters. Islands around the atoll rims serve as nesting grounds
for sea birds. Extensive and diverse shallow and mesophotic reef habitats provide essential habitat and feeding grounds for
all marine life, and the absence of local human impacts may improve recovery after coral bleaching events. Census data
have shown recent increases in the abundance of sea turtles, high numbers of nesting seabirds and high fsh abundance, at
least some of which is linked to the lack of recent harvesting. For example, across the archipelago the annual number of
green turtle clutches (Chelonia mydas) is~20,500 and increasing and the number of seabirds is ~1 million. Animal tracking
studies have shown that some taxa breed and/or forage consistently within the MPA (e.g. some reef fshes, elasmobranchs
and seabirds), suggesting the MPA has the potential to provide long-term protection. In contrast, post-nesting green turtles
travel up to 4000 km to distant foraging sites, so the protected beaches in the Chagos Archipelago provide a nesting sanctuary for individuals that forage across an ocean basin and several geopolitical borders. Surveys using divers and underwater
video systems show high habitat diversity and abundant marine life on all trophic levels. For example, coral cover can be
as high as 40–50%. Ecological studies are shedding light on how remote ecosystems function, connect to each other and
respond to climate-driven stressors compared to other locations that are more locally impacted. However, important threats
to this MPA have been identifed, particularly global heating events, and Illegal, Unreported and Unregulated (IUU) fshing
activity, which considerably impact both reef and pelagic fshes.Bertarelli Foundatio