Status Update and Interim Results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2)

Objectives: ACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization. Methods: Patients are entered into ACST-2 when revascularization is felt to be clearly indicated, when CEA and CAS are both possible, but where there is substantial uncertainty as to which is most appropriate. Trial surgeons and interventionalists are expected to use their usual techniques and CE-approved devices. We report baseline characteristics and blinded combined interim results for 30-day mortality and major morbidity for 986 patients in the ongoing trial up to September 2012. Results: A total of 986 patients (687 men, 299 women), mean age 68.7 years (SD ± 8.1) were randomized equally to CEA or CAS. Most (96%) had ipsilateral stenosis of 70-99% (median 80%) with contralateral stenoses of 50-99% in 30% and contralateral occlusion in 8%. Patients were on appropriate medical treatment. For 691 patients undergoing intervention with at least 1-month follow-up and Rankin scoring at 6 months for any stroke, the overall serious cardiovascular event rate of periprocedural (within 30 days) disabling stroke, fatal myocardial infarction, and death at 30 days was 1.0%. Conclusions: Early ACST-2 results suggest contemporary carotid intervention for asymptomatic stenosis has a low risk of serious morbidity and mortality, on par with other recent trials. The trial continues to recruit, to monitor periprocedural events and all types of stroke, aiming to randomize up to 5,000 patients to determine any differential outcomes between interventions. Clinical trial: ISRCTN21144362. © 2013 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved

Evaluation of the potential for caesium transfer from contaminated soil to the food chain as a consequence of uptake by edible vegetables

This paper analyzes the effect of caesium (Cs) concentration on seed germination, seedling growth, root uptake, and leaf uptake of Lactuca sativa to understand the potential transfer of the metal from contaminated soil to humans through the food chain. The results of germination experiments show that seed germination and seedling growth strongly depend on increasing Cs concentration, with a decrease in the number of germinated seeds compared to the control up to 13.6% and a reduction in seedling growth up to 10.3% at the highest Cs tested concentration (15 mM). Uptake experiments indicate a low transfer of Cs from soil to leaves and roots of the plants, ranging between 0.06% and 2.2%. The transfer is found to be a not-monotone function of soil potassium (K) content, with highest values corresponding to 1-2 mM K2SO4. Increasing concentrations of K lead to lower translocation of Cs from roots to leaves. Values above the average amount applied (20 and 40 mM K2SO4) almost stop the translocation, suggesting the use of a high amount of K2SO4 protects the food chain from Cs contamination

Using vernacular for environmental education in a graduate program of architecture

Bu çalışma, 22-24, Mart 2017 tarihlerinde Prague[Çek Cumhuriyetin]’de düzenlenen International Conference of Central-Bohemia-University (CBUIC) - Innovations in Science and Education Kongresi‘nde bildiri olarak sunulmuştur.Raising the environmental awareness of architectural students becomes increasingly important given today's global environmental challenges. As a prominent player in urban development, an architect needs to be concerned with the alternative ways for achieving environmental sustainability. Subsequently, environmental issues constitute an important part of the curriculum in architectural education. The scope of this study covers an elective course in an architectural graduate program of Turkey with the main aim of making fresh architects aware of their vital role in environmental objectives. In this course, the students are asked to visit and examine the vernacular architecture at a rural Turkey settlement. In this assignment, the students use a series of architectural as well as social science research methods. They present their findings visually and offer their proposals as a conclusion. Their proposals involve ways, not only, to achieve sustainability for this rural settlement but, also, to adapt the traditional design methods and materials examined within the course into contemporary design techniques. Given the acquisitions of the graduate students, this paper concludes with a recommendation for improving architectural course content by integrating applied learning.Cent Bohemia UnivUnicorn Col