Adaptive capacity of female rabbits submitted to a change in breeding practices

[EN] The aim of this study was to test the consequences of a change in breeding practices on 219 multiparous rabbit does over 2 reproductive cycles (5th and 6th insemination). Three rabbit breeding systems were defined I: intensive, S: semi-intensive and E: extensive), which varied for the females in terms of reproductive rhythm (RR: 35, 42 and 49 d, respectively) and age at first insemination (20.6, 19.6 and 16.6 wk, respectively), and for kits in terms of age at weaning (32, 35 and 30 d, respectively) and age at slaughter (63, 70 and 70 d, respectively). Females were submitted to one of the 3 systems from the 1st to the 4th artificial insemination (AI), and to another system from the 5th to the 6th AI, before returning to the initial system at the 7th AI. Consequently, they were allocated to 4 groups: I-S-I, S-I-S, S-E-S and E-S-E. Because of poor reproductive performance in the I system and despite a high growth of kits before weaning due to a more energetic diet for does, a sudden change from an I system to an S system significantly increased productivity at 28 d, from 3.37 to 5.04 kg/AI. Conversely, in the S and E systems, the females were not very sensitive to an intensification (groups S-I-S and E-S-E) or an extensification (S-E-S) of the breeding system, leading to similar productivity at 63 d (14.4 and 14.3 kg/AI, 14.4 and 13.5 kg/AI, 16.5 and 16.2 kg/AI, respectively, for groups S-I-S, E-S-E and S-E-S). The consequences of a return to the initial system deserve to be tested over a longer period.This work was supported by the CAS DAR (Cunipalm n° 9023) and by the French rabbit Interprofessional Association (CLIPP).Theau.clément, M.; Galliot, P.; Souchet, C.; Bignon, L.; Fortun-Lamothe, L. (2016). Adaptive capacity of female rabbits submitted to a change in breeding practices. World Rabbit Science. 24(4):267-273. https://doi.org/10.4995/wrs.2016.5155SWORD267273244Blanc F., Dumont B., Brunschwig G., Bocquier F., Agabriel J. 2010. Extensive ruminant farming systems highlight animal coping processes based on robustness, flexibility and plasticity. In: Robustesse, rusticité, flexibilité, plasticité, résilience, les nouveaux critères de qualité des animaux et des systèmes d'élevage. Sauvant D., Perez J.M. (Eds). Dossier INRA Prod. Anim., 23, 65-80.Maertens, L., Perez, J.M., Villamide, M., Cervera, C., Gidenne, T., Xiccato, G., 2002. Nutritive value of raw materials for rabbits: EGRAN tables 2002. World Rabbit Sci., 10: 157-166.Theau-Clément M., Boiti C., Mercier P., Falières J. 2000. Description of the ovarian status and fertilising ability of primiparous rabbit does at different lactation stage, In Proc.: 7th World Rabbit Congress, 4-7 July 2000, Valencia, Spain, Vol A: 259-266

Mixed dyslipidemias in primary care patients in France

Laurent Laforest1, Baishali M Ambegaonkar2, Thierry Souchet3, Vasilisa Sazonov2, Eric Van Ganse11Lyon University, Lyon, France; 2Merck and Co Inc, Whitehouse Station, NJ, USA; 3Merck, Sharp & Dohme, Paris, FranceObjective: To determine the prevalence of single and mixed dyslipidemias among patients treated with statins in clinical practice in France.Methods: This is a prospective, observational, cross-sectional, pharmacoepidemiologic study with a total of 2544 consecutive patients treated with a statin for at least 6 months.Main outcome measures: Prevalence of isolated and mixed dyslipidemias of low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides among all patients and among patients at high cardiovascular risk; clinical variables associated with attainment of lipid targets/normal levels in French national guidelines.Results: At least one dyslipidemia was present in 50.8% of all patients and in 71.1% of high-risk patients. Dyslipidemias of LDL-C, HDL-C, and triglycerides were present in 27.7%, 12.4%, and 28.7% of all patients, respectively, and in 51.0%, 18.2%, and 32.5% of high-risk patients, respectively. Among all subjects with any dyslipidemia, 30.9% had mixed dyslipidemias and 69.4% had low HDL-C and/or elevated triglycerides, while 30.6% had isolated elevated LDL-C; corresponding values for high-risk patients were 36.8%, 58.9%, and 41.1%. Age, gender, body mass index and Framingham Risk Score >20% were the factors significantly associated with attainment of normal levels for ≥2 lipid levels.Conclusions: At least one dyslipidemia persisted in half of all patients and two-thirds of high cardiovascular risk patients treated with a statin. Dyslipidemias of HDL-C and/or triglycerides were as prevalent as elevated LDL-C among high cardiovascular risk patients.Keywords: cholesterol, triglycerides, dyslipidemias, prevalence, treatment outcome, Franc

Influence du froid, du vent et de la pluie sur les dépenses énergétiques et la thermorégulation de sept types génétiques de brebis

International audienc

Sources of variability in the analysis of meat nutrient coenzyme Q10 for food composition databases

Coenzyme Q(10) (CoQ(10)) or ubiquinone (2,3-dimethoxy-5-methyl-6-multiprenyl-1,4-benzoquinone) is an endogenous hydroxybenzoquinone liposoluble compound which plays important physiological roles that makes it to be considered as a bioactive compound that may be used for clinical practices and as food supplement. The purpose of this work was to analyse CoQ(10) in three muscles with different oxidative patterns and determine its variability in different animal species (pork, beef, lamb and rabbit). The content of CoQ(10) ranged from 4.3 to 30.9 mu g/g meat with the highest content in those muscles with oxidative pattern. So, more specific data on type of meat cut and proportion of muscles must be given for this nutrient when reporting its content in food composition databases. (C) 2014 Elsevier Ltd. All rights reserved.Grant PROMETEO/2012/001 from Conselleria d'Educacio, Formacio i Ocupacio of Generalitat Valenciana (Spain) is fully acknowledged. Work prepared within the Unidad Asociada IAD (UPV)-IATA (CSIC) framework.Reig Riera, MM.; Aristoy, M.; Toldra, F. (2015). Sources of variability in the analysis of meat nutrient coenzyme Q10 for food composition databases. Food Control. 48:151-154. https://doi.org/10.1016/j.foodcont.2014.02.009S1511544

Motor ability in children treated for idiopathic clubfoot. A controlled pilot study

<p>Abstract</p> <p>Background</p> <p>To study motor ability at seven years of age in children treated for idiopathic clubfoot and its relation to clubfoot laterality, foot status and the amount of surgery performed.</p> <p>Methods</p> <p>Twenty children (mean age 7.5 years, SD 3.2 months) from a consecutive birth cohort from our hospital catchments area (300.000 inhabitants from southern Sweden) were assessed with the Movement Assessment Battery for Children (MABC) and the Clubfoot Assessment Protocol (CAP).</p> <p>Results</p> <p>Compared to typically developing children an increased prevalence of motor impairment was found regarding both the total score for MABC (p < 0.05) and the subtest ABC-Ball skills (p < 0.05). No relationship was found between the child's actual foot status, laterality or the extent of foot surgery with the motor ability as measured with MABC. Only the CAP item "one-leg stand" correlated significantly with the MABC (rs = -0.53, p = 0.02).</p> <p>Conclusions</p> <p>Children with idiopathic clubfoot appear to have an increased risk of motor activity limitations and it is possible that other factors, independent of the clinical status, might be involved. The ability to keep balance on one leg may be a sufficient tool for determining which children in the orthopedic setting should be more thoroughly evaluated regarding their neuromotor functioning.</p

Validity and responsiveness of the Clubfoot Assessment Protocol (CAP). A methodological study

BACKGROUND: The Clubfoot Assessment Protocol (CAP) is a multi dimensional instrument designed for longitudinal follow up of the clubfoot deformity during growth. Item reliability has shown to be sufficient. In this article the CAP's validity and responsiveness is studied using the Dimeglio classification scoring as a gold standard. METHODS: Thirty-two children with 45 congenital clubfeet were assessed prospectively and consecutively at ages of new-born, one, two, four months and two years of age. For convergent/divergent construct validity the Spearman's correlation coefficients were calculated. Discriminate validity was evaluated by studying the scores in bilateral clubfeet. The floor-ceiling effects at baseline (untreated clubfeet) and at two years of age (treated clubfeet) were evaluated. Responsiveness was evaluated by using effect sizes (ES) and by calculating if significant changes (Wilcoxons signed test) had occurred between the different measurement occasions. RESULTS: High to moderate significant correlation were found between CAP mobility I and morphology and the Dimeglio scores (r(s )= 0.77 and 0.44 respectively). Low correlation was found between CAP muscle function, mobility II and motion quality and the Dimeglio scoring system (r(s )= 0.20, 0.09 and 0.06 respectively). Of 13 children with bilateral clubfeet, 11 showed different CAP mobility I scores between right and left foot at baseline (untreated) compared with 5 with the Dimeglio score. At the other assessment occasions the CAP mobility I continued to show higher discrimination ability than the Dimeglio. No floor effects and low ceiling effects were found in the untreated clubfeet for both instruments. High ceiling effects were found in the CAP for the treated children and low for the Dimeglio. Responsiveness was good. ES from untreated to treated ranged from 0.80 to 4.35 for the CAP subgroups and was 4.68 for the Dimeglio. The first four treatment months, the CAP mobility I had generally higher ES compared with the Dimeglio. CONCLUSION: The Clubfoot Assessment Protocol shows in this study good validity and responsiveness. The CAP is more responsive when severity ranges between mild – moderate to severe, while the Dimeglio focuses more on the extremes. The ability to discriminate between different mobility status of the right and left foot in bilaterally affected children in this population was higher compared with the Dimeglio score implicating a better sensitivity for the CAP

Front Behav Neurosci

Cognitive impairment in Down syndrome (DS) has been linked to increased synaptic inhibition. The underlying mechanisms remain unknown, but memory deficits are rescued in DS mouse models by drugs targeting GABA receptors. Similarly, administration of epigallocatechin gallate (EGCG)-containing extracts rescues cognitive phenotypes in Ts65Dn mice, potentially through GABA pathway. Some developmental and cognitive alterations have been traced to increased expression of the serine-threonine kinase DYRK1A on Hsa21. To better understand excitation/inhibition balance in DS, we investigated the consequences of long-term (1-month) treatment with EGCG-containing extracts in adult mBACtgDyrk1a mice that overexpress Dyrk1a. Administration of POL60 rescued components of GABAergic and glutamatergic pathways in cortex and hippocampus but not cerebellum. An intermediate dose (60 mg/kg) of decaffeinated green tea extract (MGTE) acted on components of both GABAergic and glutamatergic pathways and rescued behavioral deficits as demonstrated on the alternating paradigm, but did not rescue protein level of GABA-synthesizing GAD67. These results indicate that excessive synaptic inhibition in people with DS may be attributable, in large part, to increased DYRK1A dosage. Thus, controlling the level of active DYRK1A is a clear issue for DS therapy. This study also defines a panel of synaptic markers for further characterization of DS treatments in murine models

Association between risk factors for injurious falls and new benzodiazepine prescribing in elderly persons

<p>Abstract</p> <p>Background</p> <p>Benzodiazepines are frequently prescribed to elderly patients' despite concerns about adverse effects leading to injurious falls. Previous studies have not investigated the extent to which patients with pre-existing risk factors for falls are prescribed benzodiazepines. The objective of this study is to assess if some of the risk factors for falls are associated with new benzodiazepine prescriptions in elderly persons.</p> <p>Methods</p> <p>Using provincial administrative databases, elderly Quebec residents were screened in 1989 for benzodiazepine use and non-users were followed for up to 5 years. Logistic regression models were used to evaluate potential predictors of new benzodiazepine use among patient baseline characteristics.</p> <p>Results</p> <p>In the 252,811 elderly patients who had no benzodiazepine prescription during the baseline year (1989), 174,444 (69%) never filled a benzodiazepine prescription and 78,367 (31%) filled at least one benzodiazepine prescription. In the adjusted analysis, several risk factors for falls were associated with statistically significant increases in the risk of receiving a new benzodiazepine prescription including the number of prescribing physicians seen at baseline (OR: 1.12; 95% CI 1.11–1.13), being female (OR: 1.20; 95% CI 1.18–1.22) or a diagnosis of arthritis (OR: 1.11; 95% CI 1.09–1.14), depression (OR: 1.42; 95% CI 1.35–1.49) or alcohol abuse (OR: 1.24; 95% CI 1.05–1.46). The strongest predictor for starting a benzodiazepine was the use of other medications, particularly anti-depressants (OR: 1.85; 95% CI 1.75–1.95).</p> <p>Conclusion</p> <p>Patients with pre-existing conditions that increase the risk of injurious falls are significantly more likely to receive a new prescription for a benzodiazepine. The strength of the association between previous medication use and new benzodiazepine prescriptions highlights an important medication safety issue.</p