Policitemia vera en un perro : su diagnóstico y su tratamiento

En este artículo presentamos un caso clínico de policitemia vera (eritrocitosis) canina con un nivel de eritropoyetina en suero normal. Fue diagnosticado y tratado mediante flebotomías repetidas, en un primer momento y con hidroxyurea posteriormente

Medical Image Segmentation to Estimate HER2 Gene Status in Breast Cancer

This work deals with the estimation of HER2 Gene status in breast tumour images treated with in situ hybridization techniques (ISH). We propose a simple algorithm to obtain the amplification factor of HER2 gene. The obtained results are very close to those obtained by specialists in a manual way. The developed algorithm is based on colour image segmentation and has been included in a software application tool for breast tumour analysis. The developed tool focus on the estimation of the seriousness of tumours, facilitating the work of pathologists and contributing to a better diagnosis

Las funciones en la resolución de problemas

En este trabajo presentamos algunas reflexiones y una propuesta acerca de la enseñanza por resolución de problemas, siendo el eje de esta última la aplicación y discusión del concepto de Función. En las carreras ´no matemáticas´ sin relegar el papel fundamental de la formación en lo teórico-conceptual los esfuerzos se desplazan hacia la aplicación de los métodos matemáticos en la resolución de problemas de las ciencias en general. Dado que el desarrollo mismo de la ciencia puede entenderse como resultado de la búsqueda de solución a los distintos problemas que aquejan al hombre, creemos que la ´enseñanza por resolución de problemas´ coadyuva a promover el cambio conceptual y metodológico que requiere actualmente el sistema educativo en general. La propuesta consiste esencialmente en el planteo de una situación problemática familiar al estudiante para, a partir de allí y siempre bajo la guía y supervisión del docente, proceder a su discusión, al planteo de conjeturas e hipótesis, resolución, verificación, etc. En este caso el problema requiere del concepto de función, concepto básico y esencial en toda disciplina que acuda a los modelos matemáticos. Creemos que este presenta características que lo signan como concepto fuerza en la implementación del cambio pretendido; que su uso en el marco de la resolución de problemas coadyuva a tal propósito pues, entre otras bondades, las funciones se caracterizan por tener cuatro representaciones o codificaciones distintas -gráfica, numérica, analítica, verbal- cada una de las cuales expresa aspectos o propiedades didácticas no equivalentes ni equiparables entre sí, lo cual, además de ampliar el espectro de posibilidades para trabajar con el estudiante, proporciona elementos para una mejor evaluación del mismo (asimilando la comprensión del concepto a la capacidad de recodificar la información desde una representación a otra)

Matemática, informática y la “renegociación” de normas preexistentes

El deseo de dar respuestas a interrogantes tales como ¿Qué tipo de conocimientos requiere una sociedad en constante transformación?; ¿qué capacidades o estrategias debemos promover para favorecer la formación de individuos social, cultural e intelectualmente plenos, comprometidos con su entorno?. ¿Será posible contemplar en las planificaciones pedagógicas la secuencia evolutiva natural de la vida (ambiente enseñanzas- memorias-comportamiento individual-comportamiento social-enseñanzas-ambiente), los tiempos biológicos requeridos para consolidar, almacenar y dar funcionalidad a la información adquirida?; ¿imponerse a la aceleración (o inercia) de los tiempos administrativos? nos lleva a reflexionar sobre la propia práctica, considerar el rediseño de la misma, a proponernos finalmente un plan de trabajo cuya estructuración contemple tanto cuestiones atinentes a la propia disciplina como, y especialmente, a todas aquellas otras que tuvieran que ver con una positiva integración Sociedad, Ciencia y Tecnología, S/C/T. En una primer etapa procedimos a investigar, caracterizar y explicitar una serie de normas “sociomatemáticas” que llamamos preexistentes y que a nuestro juicio serían inhibidoras del aprendizaje y relativas al contexto sociocultural en el que nos movemos. Por contraposición establecimos normas a renegociar con nuestros estudiantes, las que llamamos “emergentes”. Concretada la primer etapa del plan (sistema de interpretación, diseño de instrumentos para la intervención pedagógica) generamos experiencias participativas con la presencia de estudiantes y docentes a los fines de implementar los instrumentos diseñados, observar y evaluar la calidad de los mismos, el sistema de interpretación en sí. El presente trabajo trata de algunos resultados y conclusiones obtenidas en esta segunda etapa del plan

On the sub-micron aerosol size distribution in a coastal-rural site at El Arenosillo Station (SW – Spain)

This study focuses on the analysis of the sub-micron aerosol characteristics at El Arenosillo Station, a rural and coastal environment in South-western Spain between 1 August 2004 and 31 July 2006 (594 days). The mean total concentration (<i>N</i><sub>T</sub>) was 8660 cm<sup>−3</sup> and the mean concentrations in the nucleation (<i>N</i><sub>NUC</sub>), Aitken (<i>N</i><sub>AIT</sub>) and accumulation (<i>N</i><sub>ACC</sub>) particle size ranges were 2830 cm<sup>−3</sup>, 4110 cm<sup>−3</sup> and 1720 cm<sup>−3</sup>, respectively. Median size distribution was characterised by a single-modal fit, with a geometric diameter, median number concentration and geometric standard deviation of 60 nm, 5390 cm<sup>−3</sup> and 2.31, respectively. Characterisation of primary emissions, secondary particle formation, changes to meteorology and long-term transport has been necessary to understand the seasonal and annual variability of the total and modal particle concentration. Number concentrations exhibited a diurnal pattern with maximum concentrations around noon. This was governed by the concentrations of the nucleation and Aitken modes during the warm seasons and only by the nucleation mode during the cold seasons. Similar monthly mean total concentrations were observed throughout the year due to a clear inverse variation between the monthly mean <i>N</i><sub>NUC</sub> and <i>N</i><sub>ACC</sub>. It was related to the impact of desert dust and continental air masses on the monthly mean particle levels. These air masses were associated with high values of <i>N</i><sub>ACC</sub> which suppressed the new particle formation (decreasing <i>N</i><sub>NUC</sub>). Each day was classified according to a land breeze flow or a synoptic pattern influence. The median size distribution for desert dust and continental aerosol was dominated by the Aitken and accumulation modes, and marine air masses were dominated by the nucleation and Aitken modes. Particles moved offshore due to the land breeze and had an impact on the particle burden at noon, especially when the wind was blowing from the NW sector in the morning during summer time. This increased <i>N</i><sub>NUC</sub> and <i>N</i><sub>AIT</sub> by factors of 3.1 and 2.4, respectively. Nucleation events with the typical "banana" shape were characterised by a mean particle nucleation rate of 0.74 cm<sup>−3</sup> s<sup>−1</sup>, a mean growth rate of 1.96 nm h<sup>−1</sup> and a mean total duration of 9.25 h (starting at 10:55 GMT and ending at 20:10 GMT). They were observed for 48 days. Other nucleation events were identified as those produced by the emissions from the industrial areas located at a distance of 35 km. They were observed for 42 days. Both nucleation events were strongly linked to the marine air mass origin

Aerosol radiative effects in the ultraviolet, visible, and near-infrared spectral ranges using long-term aerosol data series over the Iberian Peninsula

A better understanding of aerosol radiative properties is a crucial challenge for climate change studies. This study aims at providing a complete characterization of aerosol radiative effects in different spectral ranges within the shortwave (SW) solar spectrum. For this purpose, long-term data sets of aerosol properties from six AERONET stations located in the Iberian Peninsula (southwestern Europe) have been analyzed in terms of climatological characterization and inter-annual changes. Aerosol information was used as input for the libRadtran model in order to determine the aerosol radiative effect (ARE) at the surface in the ultraviolet (AREUV), visible (AREVIS), near-infrared (ARENIR), and the entire SW range (ARESW) under cloud-free conditions. Over the whole Iberian Peninsula, yearly aerosol radiative effects in the different spectral ranges were found to be −1.1 < AREUV < −0.7, −5.7 < AREVIS < −3.5, −2.6 < ARENIR < −1.6, and −8.8 < ARESW < −5.7 (in W m−2). Monthly means of ARE showed a seasonal pattern with larger values in spring and summer. The aerosol forcing efficiency (AFE), ARE per unit of aerosol optical depth, has also been evaluated in the four spectral ranges. AFE exhibited a dependence on single scattering albedo as well as a weaker one on the Ångström exponent. AFE is larger (in absolute value) for small and absorbing particles. The contributions of the UV, VIS, and NIR ranges to the SW efficiency varied with the aerosol types. The predominant aerosol size determined the fractions AFEVIS/AFESW and AFENIR/AFESW. The AFEVIS was the dominant contributor for all aerosol types, although non-absorbing large particles caused more even contribution of VIS and NIR intervals. The AFEUV / AFESW ratio showed a higher value in the case of absorbing fine particles

Práticas de consumo e dietas informativas cidadãs

The article proposes to analyze the link of citizen information diets with other variables of political behavior such as Political Sophistication (PS), Political Ideology (PI) and Political Interest (PIn). To do this, a more complex operationalization is used than the mere consideration of exposure time to news content, understanding consumption as an articulated set of intersubjective habits. By evaluating the ideological dimension of these practices as well as the characteristics of the cognitive processing of the audiences, a survey was carried out on citizens of Córdoba (Argentina) over 16 years of age. On the one hand, it was found that the majority resort to some traditional information medium, within the framework of an important trend towards the ideological diversity of sources. On the other hand, the association between InP and news consumption was demonstrated, as well as with variables that evaluate the ideological dimension. Regarding SP, although no correlation has been shown with consumption of information from non-media or non-traditional media sources, a higher level of SP-Integration is observed among those who prioritize conversations or social networks. Likewise, the presence of conceptual differentiation is more likely among those who prefer traditional media and show a varied informational diet.El artículo propone analizar el vínculo de las dietas informativas ciudadanas con otras variables de comportamiento político como la sofisticación política (SP), la ideología política (IP) y el interés político (InP). Para ello, se recurre a una operacionalización más compleja que la mera consideración del tiempo de exposición ante contenidos noticiosos, entendiendo al consumo como un conjunto articulado de hábitos intersubjetivos. Evaluando entonces la dimensión ideológica de estas prácticas junto a las características del procesamiento cognitivo de las audiencias, se realizó una encuesta a ciudadanos de Córdoba (Argentina) mayores de 16 años. Por un lado, se encontró que la mayoría recurre a algún medio informativo tradicional, en el marco de una importante tendencia hacia la diversidad ideológica de fuentes. Por otro, se demostró la asociación entre InP y consumo informativo, así como con variables que evalúan la dimensión ideológica. En cuanto a la SP, si bien no se ha demostrado correlación con el consumo informativo de fuentes no mediáticas o mediáticas no tradicionales, se observa un mayor nivel de SP - Integración conceptual entre quienes priorizan conversaciones o redes sociales. Asimismo, se advierte más probable la presencia de diferenciación conceptual entre quienes prefieren medios tradicionales y quienes evidencian una dieta informativa variada.O artigo procura analisar a relação das dietas informativas cidadãs com outras variáveis do comportamento político como Sofisticação Política (SP), Ideologia Política (IP) e Interesse Político (InP). Para isso, utiliza-se uma operacionalização mais complexa do que a mera consideração do tempo de exposição aos conteúdos noticiosos, entendendo o consumo como um conjunto articulado de hábitos intersubjetivos. Avaliando então a dimensão ideológica dessas práticas juntamente com as características do processamento cognitivo das audiências, foi realizada uma pesquisa com cidadãos de Córdoba (Argentina) maiores de 16 anos. Por um lado, verificou-se que a maioria recorre a algum meio de informação tradicional, no quadro de uma importante tendência para a diversidade ideológica das fontes. Por outro lado, foi demonstrada a associação entre o InP e o consumo de notícias, bem como com variáveis que avaliam a dimensão ideológica. Em relação ao SP, embora não tenha sido demonstrada correlação com o consumo de informações de fontes não midiáticas ou não tradicionais, observa-se maior nível de SP-Integração entre aqueles que priorizam conversas ou redes sociais. Da mesma forma, adverte-se a presença de diferenciação conceitual é mais provável entre aqueles que preferem a mídia tradicional e apresentam uma dieta informativa variada

The REDMAAS 2014 intercomparison campaign: CPC, SMPS, UFPM and neutralizers

Ponencia presentada en:2nd Iberian Meeting on Aerosol Science and Technology (RICTA 2014) celebrado en Tarragona del 7 al 9 de julio de 2014.The Spanish network on environmental DMAs (Red Española de DMAs Ambientales, REDMAAS), working since 2010, is currently formed by six groups involved in the measurement of atmospheric aerosol size distributions by means of Differential Mobility Analyzers (DMAs). One of its activities is an annual intercomparison of mobility size spectrometers (SMPS and UFPM). In this work we show the results obtained in the 2014 campaign: the verification of DMA calibrations with latex, the results of the CPC and SMPS + UFPM intercomparisons, and a comparison of the new TSI 3087 X-ray and the former TSI 3077 85Kr neutralizers. The concentrations measured by different types of CPC were within the range of 10% of the average value. CPCs working at higher flow rates measured slightly higher concentrations, probably related to the smaller losses in the lines. All the SMPS worked at the same sampling and sheath flow rates (1:10 lpm). Four of the SMPS gave very good results for particles larger than 20 nm. The UFPM measured particle number concentrations in the average +/-10% band measured by the SMPS. Instruments working with the X-ray neutralizer measured higher concentrations than with the 85Kr neutralizers. This could mean that particle losses are smaller inside this neutralizer.This work has been financed by the Ministry of Science and Innovation (CGL2011-15008-E, CGL2010-1777, CGL2011-27020 & CGL2011-26259)

Synergetic monitoring of Saharan dust plumes and potential impact on surface: a case study of dust transport from Canary Islands to Iberian Peninsula

The synergetic use of meteorological information, remote sensing both ground-based active (lidar) and passive (sun-photometry) techniques together with backtrajectory analysis and in-situ measurements is devoted to the characterization of dust intrusions. A case study of air masses advected from the Saharan region to the Canary Islands and the Iberian Peninsula, located relatively close and far away from the dust sources, respectively, was considered for this purpose. The observations were performed over three Spanish geographically strategic stations within the dust-influenced area along a common dust plume pathway monitored from 11 to 19 of March 2008. A 4-day long dust event (13–16 March) over the Santa Cruz de Tenerife Observatory (SCO), and a linked short 1-day dust episode (14 March) in the Southern Iberian Peninsula over the Atmospheric Sounding Station "El Arenosillo" (ARN) and the Granada station (GRA) were detected.This work has been supported by the Spanish Ministry for Science and Innovation (MICINN) under the Complementary Actions CGL2008-01330-E (2009) in the frame of the Spanish and Portuguese Aerosol LIdar NETwork (SPALINET), and CGL2010-10012-E (Evaluation of lidar observations in the frame of CIEMAT/EARLINET intercomparison by airborne in-situ measurements of trace gases and aerosols, MISPA-LIDAR, 2010); projects CGL2008-05939-C03-03/CLI, CGL2007-66477-C02-01, CSD2007-00067 and CGL2010-18782 of the Spanish Ministry of Education; projects P08-RNM-3568 and P10-RNM-6299 of the Autonomous Government of Andalusia; and the EARLINET-ASOS project (EU Coordination Action, contract no. 025991 (RICA)). JLG-R thanks the Spanish Ministry of Education and the Portuguese Fundaçao para a Ciencia e a Tecnologia for supporting under grants EX2009-0700 and SFRH/BPD/63090/2009, respectively