22 research outputs found

    Clinical efficacy of coronary angioplasty of chronic occlusion in patients with previous Q-myocardial infarction

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    Objective: to evaluate the clinical effects of delayed reperfusion of chronically occluded IRA in patients after Q-myocardial infarction (Q-MI), in relation to the general and local contractility of left ventricular ejection fraction (LVEF). Material and Methods. The study included 200 patients with previous Q-MI. PCI for chronic occlusion of the IRA was performed in an average period of 1-2 months after the documented Q-MI. Complete clinical and instrumental examination of patients was performed before the PCI and after 12 months. Symptoms of angina, left ventricular ejection fraction, prevalence areas of hypo-and akinesia infarction and functional class of chronic heart failure have been evaluated. Results. Statistically significant reduction in the number of patients with symptoms of angina: 41 (20.5%) versus baseline 94 (47%), p <0,0001; significant improvement in myocardial contractile function —the number of patients with LV EF <4076% reduction (38%) to 32 (16%), p <0.0001 have been revealed. An increase in the frequency of functional classes of heart failure has not reached the statistical significance. According to the ultrasound investigation of hypo-and akinesia areas of infarction there was a statistically significant increase in the incidence of myocardial hypokinesis prevalence of 152 (76%) versus baseline 103 (51.5%), p <0.0001. Conclusions. The late recanalization of chronic occlusion (after 8 weeks post-MI) with the restoration of optimum antegrade blood flow improves left ventricular function and long-term prognosis reducing the risk of cardiovascular disorders during the period of the 12-month follow-up

    ATLAS detector and physics performance: Technical Design Report, 1

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    Chemical composition and content of polysaccharides from the yellow iris (Iris pseudacorus L.) rhizomes

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    Background: The aim of the present study was to examine the composition and content of the polysaccharide complex and polysaccharide fractions from yellow iris (Iris pseudacorus L.) rhizomes growing in Russian Federation (Moscow region). Materials and Methods:Traditional pharmacognostic methods were used in the analysis of polysaccharides as biologically active substances. The total amount of polysaccharides was determined by a gravimetric procedure with alcohol precipitation. Fractions of polysaccharides were isolated by sequential changing of solvents.The content of monosaccharides was determined by the method of high-performance liquid chromatography with refractometric detection (HPLC-RID) after acid hydrolysis. HPLC-RID procedure was performed using Chromatograph Agilent 1260 Infinity, Sugar-Pak column (300×6.5 mm), and isocratic elution mode. Results: Polysaccharide complex was isolated, the total content of polysaccharides in the rhizomes of I. pseudacorus was determined, as well as their distribution by fractions (water-soluble polysaccharides, pectic substances, hemicellulose A, hemicellulose B), the composition of individual sugars (glucose, xylose, galactose, mannose, rhamnose, arabinose) was determined for each fraction. Conclusion: In our experiment polysaccharide complex was first identified and described in detail for I. pseudacorus grown in Moscow region. © 2020 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license

    STUDIES OF SAFETY AND FUNCTIONAL AND METABOLIC EFFECTS OF NON-IONIC CONTRAST MEDIA IN CHILDREN WITH NEPHROPATHIES

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    A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82

    ИССЛЕДОВАНИЕ БЕЗОПАСНОСТИ НЕИОННЫХ РЕНТГЕНОКОНТРАСТНЫХ СРЕДСТВ И ИХ ВЛИЯНИЯ НА ФУНКЦИОНАЛЬНЫЕ И МЕТАБОЛИЧЕСКИЕ ПОКАЗАТЕЛИ У ДЕТЕЙ С НЕФРОПАТИЯМИ

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    A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82)Проведено исследование безопасности применения неионных рентгеноконтрастных средств в детской нефроурологии и определение их влияния на отдельные функциональные параметры почек и гомеостаза, отображающие риск развития контраст-индуцированной нефропатии. После введения рентгеноконтрастных средств обнаружены повышение уровней цистатина С, эндотелина, снижение фракционной экскреции натрия и гипокоагуляция. Полученные результаты свидетельствуют о том, что факторами риска развития контраст-индуцированной нефропатии могут быть гипоперфузия почек, вызывающая снижение фракционной экскреции натрия и повышение эндотелина. Повышение сывороточного цистатина С отображает негативное влияние контрастных препаратов на функцию почек. Гипокоагуляционный эффект рентгеноконтрастных средств требует предварительного исключения расстройств гемостаза. Ключевые слова: дети, контраст-индуцированная нефропатия, электролитный обмен, функции почек, цистатин С, эндотелин, гемостаз. (Педиатрическая фармакология. – 2010; 7(2):78-82

    ATLAS detector and physics performance: Technical Design Report, 2

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    ATLAS calorimeter performance

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    ATLAS computing technical proposal

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