Причини порушення сну у хворих із термічною травмою

На базі Дніпропетровського обласного центру термічної травми і пластичної хірургії обстежено 24 пацієнти зтермічними опіками шкіри. Залежно від індексу тяжкості ураження (ІТУ) і площі опіків пацієнтів було поділенона 2 групи: 1-ша група – 9 (37,5 %) пацієнтів з ІТУ 60–90 од. і загальною площею термічного ураження (30,0±6,4) %.До 2-ї групи увійшли 15 (62,5 %) пацієнтів з ІТУ 90–150 од., площею ураження (48,4±16,2) %. У пацієнтів ізтермічним ураженням шкіри у період виходу з опікового шоку розвивається порушення сну, тривалість якогозалежить від площі опіку

A comparative description of dynamics of metabolic response indexes in the phases of burn disease course depending on terms of the onset of surgical intervention.

A question of possibilities of influence on decline of progressing systemic response on the burn trauma remains open, despite actuality and active study of this problem. The aim of this work was carrying out a comparative description of dynamics of metabolic response indexes in the phases of burn disease (BD) course depending on terms of the beginning of the surgical intervention. Рatients with a thermal trauma were inspected and analyzed in this work. All the patients were estimated for the index of the thermal defeat severity, the percentage of the area of deep burn, a general area of burn, the age of a patient and the presence of respiration system burn. According to these, all the patients were divided into separate groups of research. The 1st group included 46 injured with the index of thermal defeat severity (TDS) from 61 to 90 units. The 2 group included 29 patients with the TDS index over 91 units. According to the terms of surgical intervention, patients of these groups were divided into sub-groups: 1.1 and 2.1, where the first surgical intervention was conducted five days before burn disease; 1.2 and 2.2, where the first surgical intervention was conducted five days after of burn disease. The level of cortisol and glycaemia of blood serum of injured people on different stages of inspection were taken into consideration. The diagnostically-curative program was conducted according to the clinical protocol of medical care to injured with thermal trauma. Estimating the dynamics of cortisol level, there was a considerable increase of it over the first twenty-four hours in both groups, which preserved during an acute period of burn disease. In the patients of the sub-group 2.1, with the TDS index over 91 units, who underwent early surgical tactics, the further activating of a sympathic adrenal system on the 7th day after the burn (an increase in cortisol by 82% compared with the previous indicator) was noted. From the first twenty-four hours after the burn, injured people suffered from a stress-induced hyperglycaemia which developed in all research groups, the latter did not depend on the severity of the burn trauma and did not correlate with the cortisol level of blood serum. With the early surgical treatment of burns, a more rapid normalization of blood glucose level in patients of 1.1 and 2.1 sub-groups on the 5th and 7th day of burn disease accordingly occurred

Порівняльна характеристика адаптаційних можливостей серцево-судинної системи при різних методах знеболювання у хворих із скелетною травмою на догоспітальному етапі

According to the results of a retrospective analysis of 53 victims with orthopedic trauma there was found out that the number of patients who had not been anaesthetized during the pre-hospital period was 19.9 %. There were also patients who had different kinds of anesthesia. 49.0 % - non-steroid anti-inflammatory drugs (NSAIDs), 11.3% - narcotic analgesics, 20.8 % - multimodalanalgesia. Hemodynamic parameters in a group of patients who hadn’t been anaesthetized and in NSAIDs groupwere determined by hyperdynamic type. It indicates about insufficient pain relief at this stage of care.За результатами ретроспективного аналізу 53 потерпілих із скелетною травмою виявлено, що кількість хворих, які не отримували знеболювальних препаратів на догоспітальному етапі, склала 19,9 %. Серед тих, які отримували знеболювальні препарати, 49,0 % хворих – нестероїдні протизапальні засоби (НПЗЗ), 11,3 % пацієнтів – наркотичні анальгетики, 20,8 % хворих – мультимодальну аналгезію. Гемодинамічні показники у групі хворих, які не отримували знеболювальних препаратів, та у групі знеболювання НПЗЗ визначались за гіпердинамічним типом, що свідчить про недостатній рівень знеболювання на даному етапі допомоги

Molecular-genetic factors of genital endometriosis

Article concerns data of the comparative analysis of polymorphic options of genes at patients with genital endometriosis and women in control grou

Chronic pain in children with oncopathology: ways of solving the problem

Проведено обстеження 60 дітей (3 групи по 20 дітей у кожній). У 1-й групі проводилося знеболення морфіном, у 2-й – морфіном у комбінації з габапентином, у 3-й – парацетамолом із габапентином. Досліджувалися показники серцево-судинної системи, шлунково-кишкового тракту. Використовувалися опитувальник «Самопочуття. Активність. Настрій» для визначення психоемоційних порушень, візуально-аналогова шкала та шкала облич – для визначення інтенсивності болю. Найкращою переносимість знеболення була в дітей, які отримували парацетамол із габапентином, найгіршою – в дітей, які отримували тільки опіати. Діти, в яких комбінували опіати з габапентином, мали кращі показники самопочуття та значно менше ускладнень порівняно з дітьми, котрі отримували тільки опіати

Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight

In this study, the association between maternal age at menarche (AAM)-related polymorphisms and offspring birth weight (BW) was studied. The work was performed on a sample of 716 pregnant women and their newborn

The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders

The article describes the process of neurosteroidogenesis and the effect of neurosteroids on listed receptorsin accordance with already available scientific data. In addition, this paper describes the specific role of various neurosteroids in the development of mental illnesses, including anxiety disorders, depression, and schizophreni

Clinical and genetic characteristics of preeclampsia

Preeclampsia (PE) is a severe complication of pregnancy accompanied by arterial hypertension, edema, or proteinuria with impaired functioning of various organs and systems. Recently, many scientists have especially focused on the study of genetic factors underlying the etiopathogenesis of PE, namely, the contribution of individual polymorphic loci of various candidate genes. The current study aimed to investigate the clinical characteristics of PE and the contribution of the polymorphic loci rs1042838 of Progesterone Receptor (PGR) gene and rs8068318 of the T-Box Transcription Factor 2 (TBX2) gene to the development of P

The Effect of COVID‑19 on the Incidence of Human Vector-Borne Infections Transmitted by Ixodid Ticks (Illustrated by the Example of Krasnoyarsk Territory)

In 2022, there was an increase in the incidence of tick-borne encephalitis (TBE) and ixodid tick-borne borreliosis (ITBB) in the subjects of the Russian Federation, federal districts and the country as a whole. At the same time, among people affected by ixodid ticks, the proportion of clinical forms of the diseases has increased. The aim of this study is to analyze the possible causes of the simultaneous increase in the incidence of vector-borne infections and the proportion of clinical forms among the people bitten by the ticks, using the materials on Krasnoyarsk Territory as an example. Materials and methods. We analyzed the incidence of TBE and ITBB among the people who have or haven’t had COVID‑19, the number of people affected by tick bites in 2021–2022 in Krasnoyarsk Territory. Statistical analysis is performed by standard methods of variational statistics using Excel. Results and discussion. It is shown that in the Krasnoyarsk Territory, with a decrease in the number of individuals affected by tick bites in 2022 as compared to 2021 (12216 and 13214, respectively), there was an increase in the number of cases of TBE (from 124 to 250) and ITBB (from 115 to 224), as well as the proportion of people who had clinical forms of the infections after tick bites. Among three possible explanations of the observed pattern, a decrease in the immune status of Krasnoyarsk residents who had had COVID‑19 before the contact with ticks is considered as the most likely one. Using statistical methods it was substantiated that among people with TBE and ITBB, the proportion of individuals who have had COVID‑19 is significantly higher than expected, based on the actual incidence of the Krasnoyarsk Territory population with a new coronavirus infection. Thus, COVID‑19 affects the incidence of vector-borne infections indirectly, through a change in the number of people contacts with natural stations, and directly, by changing the immune status