Managing customer knowledge during the concept development stage of the new food product development process

New product development (NPD) is a knowledge intensive process where the generation of new ideas and concepts requires detailed knowledge of both products and customers. The high reported failure rates for innovative functional beverages suggest an inability to manage customer knowledge effectively, as well as a lack of knowledge management between functional disciplines involved in the NPD process. This research explored the concept of managing customer knowledge at the early stages of the NPD process, through the use of advanced concept optimisation methods, and applied it to the development of a range of functional beverages. A conjoint - based survey was administered to four hundred customers in Ireland. This research identified two hypothetical functional beverage concepts with high levels of customer acceptance. Managing customer knowledge during the concept development stage of the NPD process can assist firms overcome customer acceptance issues associated with innovative products. Methodologies that advance both a firm's understanding of customers' choice motives and value systems, and its knowledge management process, can increase the chances of new product success in international food and beverage markets.Knowledge Management, New Product Development, Functional Beverages, Marketing,

Consumers’ Perceptions of Novel Process Technologies: The Case of High Pressure Processed Chilled Ready Meals

Consumers’ growing concerns with regard to the food supply chain continue to influence their perceptions of emerging novel food processes. The main objective of this study was to explore consumers’ perceptions and potential purchase motivations for chilled ready meals produced using high pressure processing. In-depth one-to-one soft laddering interviews were conducted in-home with 40 purchasers of chilled ready meals, aged between 18 and 44 years, living in Dublin City and County, Ireland. The in-depth discussions explored a range of issues concerning consumers’ acceptance of high pressure processing, as well as their preferences for high pressure processed chilled ready meal concepts. The results of the study showed that consumers were generally receptive towards high pressure processing of chilled ready meals. Subsequent discussions revealed where consumer acceptance issues could potentially arise concerning the application of high pressure processing to chilled ready meals. The soft laddering technique revealed distinct differences between consumer groups across consumption patterns and life stages with regard to their purchase preferences and potential purchase motivations. The insights generated from this research can assist companies design consumer-relevant communication strategies, which effectively differentiate high pressure processed chilled ready meal from incumbent products.Means-end Chain, Consumer Acceptance, Novel Process Technologies., Agricultural and Food Policy,

On Narrowing the Scientific Knowledge Gap

It is now several years since the scientific knowledge gap was pointed out clearly by C. P. Snow in his Two Cultures

Market-oriented new product development of functional beverages

Strategic reviews of the Irish Food and Beverage Industry have consistently emphasised the need for food and beverage firms to improve their innovation and marketing capabilities, in order to maintain competitiveness in both domestic and overseas markets. In particular, the functional food and beverages market has been singled out as an extremely important emerging market, which Irish firms could benefit from through an increased technological and market orientation. Although health and wellness have been the most significant drivers of new product development (NPD) in recent years, failure rates for new functional foods and beverages have been reportedly high. In that context, researchers in the US, UK, Denmark and Ireland have reported a marked divergence between NPD practices within food and beverage firms and normative advice for successful product development. The high reported failure rates for new functional foods and beverages suggest a failure to manage customer knowledge effectively, as well as a lack of knowledge management between functional disciplines involved in the NPD process. This research explored the concept of managing customer knowledge at the early stages of the NPD process, and applied it to the development of a range of functional beverages, through the use of advanced concept optimisation research techniques, which provided for a more market-oriented approach to new food product development. A sequential exploratory research design strategy using mixed research methods was chosen for this study. First, the qualitative element of this research investigated customers’ choice motives for orange juice and soft drinks, and explored their attitudes and perceptions towards a range of new functional beverage concepts through a combination of 15 in-depth interviews and 3 focus groups. Second, the quantitative element of this research consisted of 3 conjoint-based questionnaires administered to 400 different customers in each study in order to model their purchase preferences for chilled nutrient-enriched and probiotic orange juices, and stimulant soft drinks. The in-depth interviews identified the key product design attributes that influenced customers’ choice motives for orange juice. The focus group discussions revealed that groups of customers were negative towards the addition of certain functional ingredients to natural foods and beverages. K-means cluster analysis was used to quantitatively identify segments of customers with similar preferences for chilled nutrient-enriched and probiotic orange juices, and stimulant soft drinks. Overall, advanced concept optimisation research methods facilitate the integration of the customer at the early stages of the NPD process, which promotes a multi-disciplinary approach to new food product design. This research illustrated how advanced concept optimisation research methods could contribute towards effective and efficient knowledge management in the new food product development process

Calcium(II)3 (3,5-Diisopropylsalicylate)6(H2O)6 Activates Nitric Oxide Synthase: An Accounting for its Action in Decreasing Platelet Aggregation

Purposes of these studies were first; to determine whether or not Calcium(II)3 (3,5- diisopropylsalicylate)6(H2O)6 [Ca(II)3(3,5-DIPS)6], a lipophilic calcium complex, could decrease activated-platelet aggregation, and second; to determine whether or not it is plausible that Ca(II)3(3,5-DIPS)6 decreases activated-platelet aggregation by facilitating the synthesis of Nitric Oxide (NO) by Nitric Oxide Synthase (NOS). The influence of Ca(II)3(3,5-DIPS)6 on the initial rate of activated-platelet aggregation was determined by measuring the decrease in rate of increase in transmission at 550 nm for a suspension of Thrombin-CaCl2 activated platelets following the addition of 0, 50, 100, 250, or 500 μM Ca(II)3(3,5-DIPS)6. To establish that the Ca(lI)3(3,5- DIPS)6-mediated decrease in aggregation was due to activation of NOS, the effect of ʟ-NMMA, an inhibitor of NOS, on the inhibition of platelet aggregation by Ca(II)3(3,5-DIPS)6 was determined using a suspension of activated platelets contaimng 0 or 250 μM Ca(II)3(3,5-DIPS)6 without or with 1 mM ʟ-NMMA. An in vitro Bovine Brain NOS reaction mixture, containing CaCl2 for the activation of Phosphodiesterase-3' ,5'-Cyclic Nucleotide Activator required for the activation of NOS, was used to determine whether or not Ca(II)3(3,5-DIPS)6 could be used as a substitute for the addition of Ca. The decrease in absorbance at 340 nm, lambda maximum for NADPH, was measured to determine NOS activity following the addition of NOS to the complete reaction mixture containing either CaCl2, Ca(II)3(3,5-DIPS)6, or neither Ca compound. Increasing the concentration of Ca(II)3(3,5-DIPS)6 caused a concentration related decrease in activated platelet aggregation. The addition of ʟ-NMMA to activated platelets, in the absence of Ca(II)3(3,5-DIPS)6, caused a 129% increase in initial rate of platelet aggregation. The initial rate of platelet aggregation decreased 74% with the addition of 250 μM Ca(II)3(3,5-DIPS)6 and the addition of ʟ-NMMA plus 250 μM Ca(II)3(3,5-DIPS)6 caused a 197% decrease in initial rate of aggregation compared to the initial rate observed width the presence of 1 mM ʟ-NMMA alone. There was only a small, 27%, increase in initial rate of 0.4 mM NADPH oxidation when 0.9 mM CaCl2 was added to the NOS reaction mixture in comparison to the initial rate of NADPH oxidation with no addition of CaCI2. Addition of an equivalent amount of Ca in the form of Ca(II)3(3,5-DIPS)6, 333 μM, caused a 37% increase in initial rate of NADPH oxidation compared to the addition of 0.9 mM CaCl2. Addition of increasing concentrations of ʟ-NMMA plus 0.9 mM CaCl2 or 333 μM Ca(II)3(3,5-DIPS)6 to the NOS reaction mixture caused a concentration related increase in initial rate of NADPH oxidation. Addition of ʟ-NMMA while expected to decrease NADPH oxidation actually increased the rate of NADPH oxidation. Additions of 133 μM or 267 μM Ca(II)3(3,5- DIPS)6 also caused concentration related increases in initial rate of NADPH oxidation in the presence of 113 μM ʟ-NMMA. However, the addition of 533 μM Ca(II)3(3,5-DIPS)6 caused a dramatic decrease in initial rate of NADPH oxidation by NOS. It is concluded that: 1) Ca(II)3(3,5- DIPS)6 activates platelet NOS in preventing platelet aggregation, 2) in vitro NOS activity can be observed spectrophotometrically by following the consumption of NADPH as a decrease in absorbance at 340 nm, 3) Ca(II)3(3,5-DIPS)6 plays a role in enhancing Bovine Brain NOS activity resulting in an increased rate of NADPH oxidation by NOS, 4) Ca(II)3(3,5-DIPS)6 is a useful form of Ca in activating NOS and superior to CaCl2 with regard to the facilitation of a NADPH oxidation, and 5) ʟ-NMMA stimulates Bovine Brain NOS activity rather than causing an inhibition of this enzyme and must serve as a reducible substrate for Bovine Brain NOS

Legalized Abortion and the Homicide of Young Children: An Empirical Investigation

Recent research has drawn a link, sometimes a causal link, between the legalization of abortion in the late 1960s and early 1970s and the precipitous decline in crime in the 1990s. Abortion is posited to have reduced the number of potential victims and potential perpetrators, and the potential effect is examined when these individuals would be reaching their high-crime years. We examined a more proximal potential association between legalized abortion and homicide, specifically, the homicide of young children. Assuming that abortions occurred when the family had insufficient resources for the birth, one could hypothesize that children would have been at higher risk of homicide if born into these circumstances. We examined 1960-1998 U.S. mortality data for children under 5 years of age using an interrupted time series design. The legalization of abortion was not associated with a sudden change in child homicide trends. It was, however, associated with a steady decrease in the homicides of toddlers (i.e., 1- to 4-year-olds) in subsequent years. Although in the predicted direction, the decrease in homicides of children under 1 year of age was not statistically significant. Competing explanations that could be examined in the data (e.g., changes in mortality classification) do not account for the findings

The Legalization of Abortion and Subsequent Youth Homicide: A Time Series Analysis

In this article, we examine the association between the legalization of abortion with the 1973 Roe v. Wade decision and youth homicide in the 1980s and 1990s. An interrupted time series design was used to examine the deaths of all U.S. 15- to 24-year-olds that were classified as homicides according to the International Classification of Diseases (codes E960-969) from 1970 to 1998. The legalization of abortion is associated over a decade later with a gradual reduction in the homicides of White and non-White young men. The effect on the homicides of young women is minimal. We conclude that the 1990s decline in the homicide of young men is statistically associated with the legalization of abortion. Findings are not consistent with several alternative explanations, such as changes in the crack cocaine drug market. It is almost inconceivable that in the United States of today, policies affecting the choice to have children would be justified as a means to control crime. Yet, if the legalization of abortion had this unintended effect, the full range of policy implications needs to be discussed

Histological Observation of Islet Hemorrhage Induced by Diagnostic Ultrasound with Contrast Agent in Rat Pancreas

Contrast enhanced diagnostic ultrasound CEDUS has been shown to induce capillary hemorrhage in heart and kidney. This study characterized the capillary hemorrhage induced in rat pancreas. The pancreata of anesthetized hairless rats were accessed by laparotomy. A 1.5 MHz diagnostic ultrasound probe with 2.3 MPa peak rarefactional pressure amplitude and 1 s intermittent trigger was used to scan the pancreas, located at the focus (3.8 cm), through saline coupling. The probe was swept to expose the entire organ in 5 min during infusion of Definity® contrast agent at 10 µL/kg/min, and this was repeated in a reverse sweep. The entire pancreas was removed, spread flat for fixation and histological slides were prepared from the mid-plane. Slides were scored blind for islet hemorrhage over the entire area of the organ. Intra-islet microlesions were evident and hemorrhage surrounded many islets. The hemorrhage often impacted nearby acini, and expanded into inter-lobular septa. In CEDUS pancreata removed soon after scanning, 76.2±11.8% (n = 6) of islets had evidence of hemorrhage and/or islet microlesions compared to 1.1±2.5% (n = 5) for sham CEDUS (P<0.001). In pancreata removed after 4 hr, fibrin formation was detected by immunohistology in the hemorrhage and intra-islet microlesions. Diagnostic ultrasound with contrast agent induced substantial capillary hemorrhage in rat pancreas, concentrated particularly in the islets

Homicide and geographic access to gun dealers in the United States

<p>Abstract</p> <p>Background</p> <p>Firearms are the most commonly used weapon to commit homicide in the U.S. Virtually all firearms enter the public marketplace through a federal firearms licensee (FFL): a store or individual licensed by the federal government to sell firearms. Whether FFLs contribute to gun-related homicide in areas where they are located, in which case FFLs may be a homicide risk factor that can be modified, is not known.</p> <p>Methods</p> <p>Annual county-level data (1993–1999) on gun homicide rates and rates of FFLs per capita were analyzed using negative binomial regression controlling for socio-demographic characteristics. Models were run to evaluate whether the relation between rates of FFLs and rates of gun homicide varied over the study period and across counties according to their level of urbanism (defined by four groupings, as below). Also, rates of FFLs were compared against FS/S – which is the proportion of suicides committed by firearm and is thought to be a good proxy for firearm availability in a region – to help evaluate how well the FFL variable is serving as a way to proxy firearm availability in each of the county types of interest.</p> <p>Results</p> <p>In major cities, gun homicide rates were higher where FFLs were more prevalent (rate ratio [RR] = 1.70, 95% CI 1.03–2.81). This association increased (p < 0.01) from 1993 (RR = 1.69) to 1999 (RR = 12.72), due likely to federal reforms that eliminated low-volume dealers, making FFL prevalence a more accurate exposure measure over time. No association was found in small towns. In other cities and in suburbs, gun homicide rates were significantly lower where FFLs were more prevalent, with associations that did not change over the years of the study period. FFL prevalence was correlated strongly (positively) with FS/S in major cities only, suggesting that the findings for how FFL prevalence relates to gun homicide may be valid for the findings pertaining to major cities but not to counties of other types.</p> <p>Conclusion</p> <p>Modification of FFLs through federal, state, and local regulation may be a feasible intervention to reduce gun homicide in major cities.</p