Specimen Test of Large-Heat-Input Fusion Welding Method for Use of SM570TMCP

In this research, the large-heat-input welding conditions optimized to use the rear plate and the high-performance steel of SM570TMCP, a new kind of steel suitable for the requirements of prospective customers, are proposed. The goal of this research is to contribute to securing the welding fabrication optimized to use the high-strength steel and rear steel plates in the field of construction industry in the future. This research is judged to contribute to securing the welding fabrication optimized to use the high-strength steel and rear steel plates in the field of construction industry in the future

The effects of a workplace intervention on employees’ cortisol awakening response

Work-related stressors are known to adversely affect employees’ stress physiology, including the cortisol awakening response (CAR)–or the spike in cortisol levels shortly after people wake up that aids in mobilizing energy. A flat or blunted CAR has been linked to chronic stress and burnout. This daily diary study tested the effects of a workplace intervention on employed parents’ CAR. Specifically, we tested whether the effects of the intervention on CAR were moderated by the type of days (workday versus non-work day). Data came from 94 employed parents from an information technology firm who participated in the baseline and 12-month diurnal cortisol components of the Work, Family, and Health Study, a group-randomized field experiment. The workplace intervention was designed to reduce work-family conflict (WFC) and implemented after the baseline data collection. Diurnal salivary cortisol was collected on 4 days at both baseline and 12 months. Multilevel modeling revealed that the intervention significantly increased employees’ CAR at 12 months on non-workdays, but this was not evident on workdays or for employees in the usual practice condition. The results provide evidence that the intervention was effective in enhancing employees’ biological stress physiology particularly during opportunities for recovery that are more likely to occur on non-work days.National Institute on Aging (U01AG027669)Work, Family & Health Network (U01HD051217)Work, Family & Health Network (U01HD051218)Work, Family & Health Network (U01HD051256)Work, Family & Health Network (U01HD051276)U.S. Army Research Institute for the Behavioral and Social SciencesNational Institute for Occupational Safety and Health (U010H008788)Alfred P. Sloan Foundation (2004-12-4)William T. Grant Foundation (9844)National Institutes of Health (U.S.) (Penn State General Clinical Research Center. Grant M01-RR-10732

Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation

Cells have evolved sophisticated mechanisms to maintain genomic integrity in response to DNA damage. Ionizing radiation (IR)-induced DNA damage results in the formation of IR-induced foci (iRIF) in the nucleus. The iRIF formation is part of the DNA damage response (DDR), which is an essential signaling cascade that must be strictly regulated because either the loss of or an augmented DDR leads to loss of genome integrity. Accordingly, negative regulation of the DDR is as critical as its activation. In this study, we have identified ring finger protein 126 (RNF126) as a negative regulator of the DDR from a screen of iRIF containing 53BP1. RNF126 overexpression abolishes not only the formation of 53BP1 iRIF but also of RNF168, FK2, RAP80, and BRCA1. However, the iRIF formation of H2AX, MDC1, and RNF8 is maintained, indicating that RNF126 acts between RNF8 and RNF168 during the DDR. In addition, RNF126 overexpression consistently results in the loss of RNF168-mediated H2A monoubiquitination at lysine 13/15 and inhibition of the non-homologous end joining capability. Taken together, our findings reveal that RNF126 is a novel factor involved in the negative regulation of DDR, which is important for sustaining genomic integrity

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers

Currently no pharmacogenomics-based criteria exist to guide clinicians in identifying individuals who are at risk of hearing loss from cisplatin-based chemotherapy. This review summarizes findings from pharmacogenomic studies that report genetic polymorphisms associated with cisplatin-induced hearing loss and aims to (1) provide up-to-date information on new developments in the field, (2) provide recommendations for the use of pharmacogenetic testing in the prevention, assessment, and management of cisplatin-induced hearing loss in children and adults, and (3) identify knowledge gaps to direct and prioritize future research. These practice recommendations for pharmacogenetic testing in the context of cisplatin-induced hearing loss reflect a review and evaluation of recent literature, and are designed to assist clinicians in providing optimal clinical care for patients receiving cisplatin-based chemotherapy

Musical borrowing in four twentieth-century works for viola by Hindemith, Bloch, Bacewicz, and Shostakovich

Musical borrowing is very common in music and occurs in a wide variety of genres and is used for many different reasons. While many scholars have commented on the procedure in twentieth-century music, this document explores the nature of musical borrowing in solo works of a single instrument, the viola. Paul Hindemith’s Der Schwanendreher (a viola concerto), Ernest Bloch’s Suite Hébraïque (for viola and piano), Grazyna Bacewicz’s Viola Concerto, and Dmitri Shostakovich’s Viola Sonata are all examined in terms of their musical borrowing. J. Peter Burkholder’s fourteen categories of musical borrowing are used to differentiate the types of borrowing that take place in these works. Interpretive issues are also carefully considered, as is the role of quotation and borrowing within the context of dialogue between solo and accompaniment. This document will contribute to the understanding of borrowing procedures in twentieth-century music as well as provide interpretative insight for violist

Automatic Position Information of Web-Openings of Building Using Minimized Strain Energy Topology Optimization

This study presents a new engineering practice and idea that material topology optimization results may be utilized to optimally decide the positions of web-openings of structural members in a building structure. Material topology optimization utilizes element densities as design parameters, that is, nominal constructional material, and then optimal material distributions of densities between voids (0) and solids (1) in a given design domain represent the determination of topology and shape. That means that regions with element density values become occupied by solids in a design domain, while there are only void phases in regions where no density values exist. Therefore, the void regions of topology optimization results may provide design information that decides appropriate depositions of web-opening in structure. Numerical examples demonstrate the efficiency of the present methodological design information using optimization techniques to automatically resolve the building design of proper deposition of web-openings