A Better environment for disabled children

None provided

The marital adjustment processes of Korean working-class couples

The purpose of this study was to replicate Rubin\u27s (1976) work which intensively studied family life of white American working-class people, in Korean culture, and further to extend the work to investigate the similarities and differences of the marital adjustment process between Korean working-class couples who are living with their parents (in-laws) and couples who are living independently;The sample for this research was thirty-two Korean couples who had no more than a high-school education; whose husband worked in a blue-collar occupation; and who had at least one child under twelve years. For purpose of comparison, one half of the couples selected were living with their parents (in-laws);As a method, in-depth interviews were used and at the end of the interviews, self-administered questionnaires on marital adjustment (Dyadic Adjustment Scale: Spanier, 1976) were given to the couples;This study regards marital adjustment as a process and deals with three stages of adjustment: (1) Adjustment to Marriage; (2) Adjustment to Relationships with in-laws; and (3) Adjustment to Parenthood;They are very different from Rubin\u27s white American working-class couples on their adjustment process to parenthood. They regard the difficulty with the first child as natural to being a parent and most of them mention that their marital relationship has improved;Korean working-class wives seem to be more dissatisfied with their marriages and demand far more communication, companionship, and expression of feelings than husbands do;The marital adjustment process of Korean couples who live with their parents (in-laws) is not the same as that of those who live independently. When the living arrangement is positive, it eases the role transition to parenthood for the young couples, providing them with much help in caring for babies. On the contrary, it makes the marital adjustment process of the couples difficult, interrupting their companionship, disclosure of affection, and open discussion of marital conflicts

Housing Attitudes and Preferences as Expressed by Single Graduate Students at Oklahoma State University

Housing and Interior Desig

Development of Indexes for the Performance Evaluation of e-SCM

Web-based sharing of information across the supply chain can bring a host of advantages to the trading partners. lower cost, leaner inventories, and more efficient shipping are just the beginning. eSCM is technology-enabled ability to concurrently manage high levels of complexity and multiple external relationships. This study presents that the development of indexes for the performance evaluation of e-SCM should be given more priority by companies giving weights to each index. Deductive research is used for the development of evaluation items and AHP method for the development of weights of the items. According to priority of each category - relationship between supplier and company, relationship between partner and company and relationship between customer and company- is as follows; Company driven type: relationship between customer and company, relationship between supplier and company, relationship between partner and company. Market portal type: relationship between supplier and company, relationship between customer and company, relationship between partner and company

Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein–protein interactions

AbstractTestis-specific poly(A) polymerase (TPAP) is a cytoplasmic poly(A) polymerase that is highly expressed in round spermatids. We identified germ cell-specific gene 1 (GSG1) as a TPAP interaction partner protein using yeast two-hybrid and coimmunoprecipitation assays. Subcellular fractionation analysis showed that GSG1 is exclusively localized in the endoplasmic reticulum (ER) of mouse testis where TPAP is also present. In NIH3T3 cells cotransfected with TPAP and GSG1, both proteins colocalize in the ER. Moreover, expression of GSG1 stimulates TPAP targeting to the ER, suggesting that interactions between the two proteins lead to the redistribution of TPAP from the cytosol to the ER.Structured summaryMINT-6168263:Gsg1 (uniprotkb:Q8R1W2), TPAP (uniprotkb:Q9WVP6) and Calmegin (uniprotkb:P52194) colocalize (MI:0403) by cosedimentation (MI:0027)MINT-6168204, MINT-6168178:Gsg1 (uniprotkb:Q8R1W2) and TPAP (uniprotkb:Q9WVP6) colocalize (MI:0403) by fluorescence microscopy (MI:0416)MINT-6167930:Gsg1 (uniprotkb:Q8R1W2) physically interacts (MI:0218) with TPAP (uniprotkb:Q9WVP6) by two-hybrid (MI:0018)MINT-6168112, MINT-6168011, MINT-6168054:Gsg1 (uniprotkb:Q8R1W2) physically interacts (MI:0218) with TPAP (uniprotkb:Q9WVP6) by coimmunoprecipitation (MI:0019)MINT-61668069, MINT-6168101:Gsg1 (uniprotkb:Q8R1W2) physically interacts (MI:0218) with TPAP (uniprotkb:Q9WVP6) by pull-down (MI:0096)MINT-6168218:Gsg1 (uniprotkb:Q8R1W2) and GRP78 (uniprotkb:P20029) colocalize (MI:0403) by fluorescence microscopy (MI:0416)MINT-6168381:TPAP (uniprotkb:Q9WVP6) and GRP78 (uniprotkb:P20029) colocalize (MI:0403) by fluorescence microscopy (MI:0416

Comparison of Clinical Manifestations between Patients with Ocular Myasthenia Gravis and Generalized Myasthenia Gravis

PURPOSE: To compare the clinical manifestations between patients with ocular myasthenia gravis and those with generalized myasthenia gravis (MG). METHODS: The medical records of 71 patients diagnosed with MG between January 1995 and December 2007 were reviewed. Demographics, sensitivities of diagnostic methods, the presence of systemic autoimmune diseases, ophthalmic complications caused by MG, and treatments were evaluated and compared. RESULTS: Fourteen patients (20%) were diagnosed with ocular MG and 57 patients (80%) with generalized MG. Sensitivities of anti-acetylcholine receptor antibody and repetitive nerve stimulation tests were significantly higher in the generalized MG group (84%, 89%) compared to those in the ocular MG group (50%, 54%) (p = 0.011, p = 0.008). The sensitivity of the neostigmine test was the highest in both groups (98% of generalized MG, 79% of ocular MG), and the difference between the two groups was borderline significant (p = 0.058). The most common symptoms were ptosis and diplopia, and both groups presented with pain, blurred vision, and tearing. Systemic autoimmune disease was more prominent in the generalized MG group (21%) than in the ocular MG group (14%), and steroid therapy was used more frequently in the generalized MG group (82%) than in the ocular MG group (57%). Ophthalmic complications associated with long-term steroid treatment were more profound in the generalized MG (30%) compared to those of the ocular MG (21%). CONCLUSIONS: The generalized MG group was associated with higher sensitivities to diagnostic tests, more systemic steroid use, higher ophthalmic complications caused by systemic autoimmune disease, and long-term steroid treatment compared to those of the ocular MG groupope

ERK is a novel regulatory kinase for poly(A) polymerase

Poly(A) polymerase (PAP), which adds poly(A) tails to the 3′ end of mRNA, can be phosphorylated at several sites in the C-terminal domain. Phosphorylation often mediates regulation by extracellular stimuli, suggesting PAP may be regulated by such stimuli. In this study, we found that phosphorylation of PAP was increased upon growth stimulation and that the mitogen-activated protein kinase ERK was responsible for the increase in phosphorylation. We identified serine 537 of PAP as a unique phosphorylation site by ERK. PAP phosphorylation of serine 537 by ERK increased its nonspecific polyadenylation activity in vitro. This PAP activity was also activated by stimulation of ERK with phorbol-12-myristate-13-acetate in vivo. These data suggest that ERK is a novel regulatory kinase for PAP and further, that PAP activity could be regulated by extracellular stimuli through an ERK-dependent signaling pathway(s)

INDAHNYA PERBEDAAN SEBAGAI TEMA PENCIPTAAN KARYA SENI LUKIS

Abstrak Manusia adalah makhluk yang indah dan yang menyenangi keindahan. Keindahan pada dasarnya meliputi sejumlah kualitas pokok tertentu yang terdapat pada suatu hal. Kualitas keindahan ditunjukkan oleh kesatuan (unity), keselarasan (harmony), kesetangkupan (symmetry), keseimbangan (balance), dan perlawanan (contrast). Tulisan ini menjelaskan berbagai macam keindahan dalam perbedaan yang pada dasarnya sudah ada sejak penciptaan segala sesuatu di dunia ini. Perbedaan yang asli menjadi sangat indah karena dibentuk oleh berbagai macam keunikan yang melekat pada setiap ciptaan, seperti jenis, ukuran, warna, bentuk, fungsi, isi dan lain-lain. Judul tulisan ini, yaitu “Indahnya Perbedaan” tidak hanya dapat diterapkan dalam kehidupan semua ciptaan yang lain, tetapi juga dapat diterapkan dalam kehidupan bersama sebagai satu masyarakat. Kata kunci: keindahan, perbedaan dan keaslia

INDAHNYA PERBEDAAN SEBAGAI TEMA PENCIPTAAN KARYA SENI LUKIS

Abstrak Manusia adalah makhluk yang indah dan yang menyenangi keindahan. Keindahan pada dasarnya meliputi sejumlah kualitas pokok tertentu yang terdapat pada suatu hal. Kualitas keindahan ditunjukkan oleh kesatuan (unity), keselarasan (harmony), kesetangkupan (symmetry), keseimbangan (balance), dan perlawanan (contrast). Tulisan ini menjelaskan berbagai macam keindahan dalam perbedaan yang pada dasarnya sudah ada sejak penciptaan segala sesuatu di dunia ini. Perbedaan yang asli menjadi sangat indah karena dibentuk oleh berbagai macam keunikan yang melekat pada setiap ciptaan, seperti jenis, ukuran, warna, bentuk, fungsi, isi dan lain-lain. Judul tulisan ini, yaitu “Indahnya Perbedaan” tidak hanya dapat diterapkan dalam kehidupan semua ciptaan yang lain, tetapi juga dapat diterapkan dalam kehidupan bersama sebagai satu masyarakat. Kata kunci: keindahan, perbedaan dan keaslia