127 research outputs found
Impacts of an aerosol layer on a mid-latitude continental system of cumulus clouds: how do these impacts depend on the vertical location of the aerosol layer?
Using the large-eddy simulation framework, effects of an aerosol layer on warm cumulus clouds in the Korean Peninsula when the layer is above or around the cloud tops in the upper atmosphere are examined. Also, these effects are compared to effects of an aerosol layer when it is around or below the cloud bases in the low atmosphere. Simulations show that when the aerosol layer is in the low atmosphere, aerosols absorb solar radiation and radiatively heat up air enough to induce greater instability, stronger updrafts and more cloud mass than when the layer is in the upper atmosphere. As aerosol concentrations in the layer decrease, the aerosol radiative heating gets weaker to lead to less instability, weaker updrafts and less cloud mass when the layer is in the low atmosphere. This in turn makes differences in cloud mass, which are between a situation when the layer is in the low atmosphere and that when the layer is in the upper atmosphere, smaller. It is found that the transportation of aerosols by updrafts reduces aerosol concentrations in the aerosol layer, which is in the low atmosphere, and in turn reduces the aerosol radiative heating, updraft intensity and cloud mass. It is also found that the presence of aerosol impacts on radiation suppresses updrafts and reduces clouds. Aerosols affect not only radiation but also aerosol activation. In the absence of aerosol impacts on radiation, aerosol impacts on the droplet nucleation increases cloud mass when the layer is in the low atmosphere as compared to a situation when the layer is in the upper atmosphere. As aerosol impacts on radiation team up with those on the droplet nucleation, differences in cloud mass, which are between a situation when the layer in the low atmosphere and that when the layer is in the upper atmosphere, get larger. This is as compared to a situation when there is no aerosol impacts on radiation and only aerosol impacts on the droplet nucleation.</p
Approximation of most penetrating particle size for fibrous filters considering Cunningham slip correction factor
In the estimation of the aerosol single fiber efficiency using fibrous filters, there is a size range, where the particles penetrate most effectively through the fibrous collectors, and corresponding minimum single fiber efficiency. For small particles in which the diffusion mechanism is dominant, the Cunningham slip correction factor (Cc) affects the single fiber efficiency and the most penetrating particle size (MPPS). Therefore, for accurate estimation, Cc is essential to be considered. However, many previous studies have neglected this factor because of its complexity and the associated difficulty in deriving the appropriate parameterization particularly for the MPPS. In this study, the expression for the MPPS, and the corresponding expression for the minimum single fiber efficiency are analytically derived, and the effects of Cc are determined. In order to accommodate the slip factor for all particle-size ranges, Cc is simplified and modified. Overall, the obtained analytical expression for the MPPS is in a good agreement with the exact solution
Four Cases of a Cerebral Air Embolism Complicating a Percutaneous Transthoracic Needle Biopsy
A percutaneous transthoracic needle biopsy is a common procedure in the practice of pulmonology. An air embolism is a rare but potentially fatal complication of a percutaneous transthoracic needle biopsy. We report four cases of a cerebral air embolism that developed after a percutaneous transthoracic needle biopsy. Early diagnosis and the rapid application of hyperbaric oxygen therapy is the mainstay of therapy for an embolism. Prevention is the best course and it is essential that possible risk factors be avoided
Smart fiber orientation monitoring system in a mold via electrical route modeling
The orientation of unidirectional carbon fibers (UDCFs) in a manufacturing process is critical to the mechanical properties of carbon fiber reinforced plastics (CFRPs). This study presents a method to monitor the orientation of UDCFs on a mold using electrical resistance during the CFRP manufacturing process. An equivalent electrical model for UDCFs was proposed to develop an in situ sensor in a mold. The orientation of UDCFs during the CFRP manufacturing process is investigated in terms of its orthotropic electrical properties. The proposed technique can have strong implications on in situ monitoring of composite molding process where the fiber orientation is unseen by monitoring electrical resistance with Cu tapes as electrodes
Chronic obstructive lung disease after ammonia inhalation burns: a report of two cases
Anhydrous ammonia is a commonly used chemical in industry. Ammonia gas inhalation causes thermal injuries and alkali burns in the airway and lung parenchyma. Previous case reports have stated that respiratory sequelae after acute ammonia inhalation burns were associated with structural lung disease, such as bronchiectasis or interstitial lung disease. We herein report two cases of long-term sequelae with persistent airflow limitation after ammonia inhalation burns
Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy
<p>Abstract</p> <p>Backgrounds</p> <p>We conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment.</p> <p>Methods</p> <p>Patients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10~20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI)-diffusion tensor imaging (DTI), brain perfusion single-photon emission computed tomography (SPECT), and various evaluation tools for motor and cognitive functions.</p> <p>Results</p> <p>Twenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25%) as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia.</p> <p>Conclusions</p> <p>Autologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.</p
Virologic response is not durable after adefovir discontinuation in lamivudine-resistant chronic hepatitis B patients
Hepatitis B surface antigen titer is a good indicator of durable viral response after entecavir off-treatment for chronic hepatitis B
Background/Aims Clear indicators for stopping antiviral therapy in chronic hepatitis B (CHB) patients are not yet available. Since the level of hepatitis B surface antigen (HBsAg) is correlated with covalently closed circular DNA, the HBsAg titer might be a good indicator of the off-treatment response. This study aimed to determine the relationship between the HBsAg titer and the entecavir (ETV) off-treatment response. Methods This study analyzed 44 consecutive CHB patients (age, 44.6±11.4 years, mean±SD; men, 63.6%; positive hepatitis B envelope antigen (HBeAg) at baseline, 56.8%; HBV DNA level, 6.8±1.3 log10 IU/mL) treated with ETV for a sufficient duration and in whom treatment was discontinued after HBsAg levels were measured. A virological relapse was defined as an increase in serum HBV DNA level of >2000 IU/mL, and a clinical relapse was defined as a virological relapse with a biochemical flare, defined as an increase in the serum alanine aminotransferase level of >2 × upper limit of normal. Results After stopping ETV, virological relapse and clinical relapse were observed in 32 and 24 patients, respectively, during 20.8±19.9 months of follow-up. The cumulative incidence rates of virological relapse were 36.2% and 66.2%, respectively, at 6 and 12 months, and those of clinical relapse were 14.3% and 42.3%. The off-treatment HBsAg level was an independent factor associated with clinical relapse (hazard ratio, 2.251; 95% confidence interval, 1.076–4.706; P=0.031). When patients were grouped according to off-treatment HBsAg levels, clinical relapse did not occur in patients with an off-treatment HBsAg level of ≤2 log10 IU/mL (n=5), while the incidence rates of clinical relapse at 12 months after off-treatment were 28.4% and 55.7% in patients with off-treatment HBsAg levels of >2 and ≤3 log10 IU/mL (n=11) and >3 log10 IU/mL (n=28), respectively. Conclusion The off-treatment HBsAg level is closely related to clinical relapse after treatment cessation. A serum HBsAg level of <2 log10 IU/mL is an excellent predictor of a sustained off-treatment response in CHB patients who have received ETV for a sufficient duration
Clinical outcomes of transjugular intrahepatic portosystemic shunt for portal hypertension: Korean multicenter real-practice data
Background/AimsThis retrospective study assessed the clinical outcome of a transjugular intrahepatic portosystemic shunt (TIPS) procedure for managing portal hypertension in Koreans with liver cirrhosis.MethodsBetween January 2003 and July 2013, 230 patients received a TIPS in 13 university-based hospitals.ResultsOf the 229 (99.6%) patients who successfully underwent TIPS placement, 142 received a TIPS for variceal bleeding, 84 for refractory ascites, and 3 for other indications. The follow-up period was 24.9±30.2 months (mean±SD), 74.7% of the stents were covered, and the primary patency rate at the 1-year follow-up was 78.7%. Hemorrhage occurred in 30 (21.1%) patients during follow-up; of these, 28 (93.3%) cases of rebleeding were associated with stent dysfunction. Fifty-four (23.6%) patients developed new hepatic encephalopathy, and most of these patients were successfully managed conservatively. The cumulative survival rates at 1, 6, 12, and 24 months were 87.5%, 75.0%, 66.8%, and 57.5%, respectively. A high Model for End-Stage Liver Disease (MELD) score was significantly associated with the risk of death within the first month after receiving a TIPS (P=0.018). Old age (P<0.001), indication for a TIPS (ascites vs. bleeding, P=0.005), low serum albumin (P<0.001), and high MELD score (P=0.006) were associated with overall mortality.ConclusionsA high MELD score was found to be significantly associated with early and overall mortality rate in TIPS patients. Determining the appropriate indication is warranted to improve survival in these patients
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