Some Chelates of Al(III) & Their Reactions

408-40

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

Sulphur Dioxide Insertion Reactions in Triphenylantimony(V) Bis-chelates

1121-112

Relaxation dynamics in crab hemolymph protein: A biophysical approach through dielectric spectroscopy

307-310Physical properties of biological systems are very complex and often difficult to tune with biological properties. Here we report the physical properties of fresh water crab hemolymph; a fluid analogues to the blood in vertebrates. This may be the first ever attempt in case of crab hemolymph to study dielectric properties such as permittivity (ε') dielectric loss (ε"), static dielectric constant (ε0) and relaxation time (τ) in order to know the structural properties of hemolymph in the surrounding of water molecules. Time domain reflectometry (TDR) in the frequency region of 10 MHz-30 GHz has been used for this purpose for two concentrations at room temperature. Havriliak – Negami equation is used to obtained complex permittivity spectra. The data obtained using TDR was fitted in two-Debye model. Hemolymph in water surrounding shows two relaxations modes. The low frequency relaxation (β-relaxation) observed around 90 MHz often attributed to the rotation of polar protein molecules in hemolymph and high frequency relaxation (γ-relaxation) observed around 18-20 GHz corresponds to the rotation of pure water molecules. It has been observed that the static dielectric constants as well as both low and high frequency relaxation times are little concentration dependent