Sex- and age-related differences in the management and outcomes of chronic heart failure: an analysis of patients from the ESC HFA EORP Heart Failure Long-Term Registry

Aims: This study aimed to assess age- and sex-related differences in management and 1-year risk for all-cause mortality and hospitalization in chronic heart failure (HF) patients. Methods and results: Of 16 354 patients included in the European Society of Cardiology Heart Failure Long-Term Registry, 9428 chronic HF patients were analysed [median age: 66 years; 28.5% women; mean left ventricular ejection fraction (LVEF) 37%]. Rates of use of guideline-directed medical therapy (GDMT) were high (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists: 85.7%, 88.7% and 58.8%, respectively). Crude GDMT utilization rates were lower in women than in men (all differences: P\ua0 64 0.001), and GDMT use became lower with ageing in both sexes, at baseline and at 1-year follow-up. Sex was not an independent predictor of GDMT prescription; however, age >75 years was a significant predictor of GDMT underutilization. Rates of all-cause mortality were lower in women than in men (7.1% vs. 8.7%; P\ua0=\ua00.015), as were rates of all-cause hospitalization (21.9% vs. 27.3%; P\ua075 years. Conclusions: There was a decline in GDMT use with advanced age in both sexes. Sex was not an independent predictor of GDMT or adverse outcomes. However, age >75 years independently predicted lower GDMT use and higher all-cause mortality in patients with LVEF 6445%

Sustainable Organic Garden in poor community in Santana de Parnaiba

The organic garden is based on clean and sustainable technologies without the use of any pesticides. Every day people are more and more concerned about their physical well-being, therefore they also try to feed themselves with healthier and natural products. The garden was set up in the premises of Rainha da Paz. We used organic seeds and plants supplied by producers and these were planted in prepared soil with compost material. The aim of this project was to create an organic garden and composting, allowing the use of small spaces and reuse of materials that would be discarded in nature. At the same time we will enable the teenagers and all the staff of the institution to be aware of the necessity and challenges in building a healthier planet, through free training of the disadvantaged community. The first harvest occurred in June, when we started to use the vegetables in the food preparation given to children. At the same time we offered cooking workshop to mothers, who started to include them in their diet and also initiated domestic planting. The organic garden and the workshop enabled mothers to broaden their knowledge and actions in relation to tillage and the use of plants for nutritional purposes to maintain the children's well-being

Effect of alternate and simultaneous grazing on endoparasite infection in sheep and cattle

This experiment was carried out on 8 ha of Panicum maximum cv. Tanzania pastures, with rotational grazing consisting of 7 days of occupation and 21 days of rest. Four treatments were evaluated: cattle grazing alone (BOV), sheep grazing alone (OVI), cattle and sheep grazing simultaneously (SIM) and cattle grazing followed by sheep (alternate - ALT). Twenty heifers and 30 male Santa Inês lambs were used. Fecal egg count (FEC) and fecal cultures were carried out. Blood was also collected to examine red and white cell series, total plasma protein (TPP), albumin and hemoglobin. FEC and estimated nematode pathogenicity index in sheep were lower in the SIM treatment. The Haemonchus spp. proportion was higher in isolated grazing systems. For sheep, mixed grazing was shown to reduce endoparasite infection, and SIM was better than ALT. For cattle, no difference between grazing systems was seen. Therefore, simultaneous grazing (sheep and cattle) may be a tool for reducing the need for anthelmintic treatments in sheep

Effect of alternate and simultaneous grazing on endoparasite infection in sheep and cattle

O experimento foi realizado em 8ha de pasto de Panicum maximum cv. Tanzania, com pastejo rotacionado de 7 dias de ocupação e 21 dias de descanso. Quatro tratamentos foram avaliados: bovinos pastejando isoladamente (BOV), ovinos pastejando isoladamente (OVI), bovinos e ovinos pastejando simultaneamente (SIM), e bovinos pastejando previamente aos ovinos (alternado - ALT). Vinte novilhas e 30 cordeiros Santa Inês foram utilizados. Contagem de ovos nas fezes (FEC) e coproculturas foram realizados. Sangue também foi colhido para examinar a série vermelha e branca, proteínas plasmáticas totais (TPP), albumina e hemoglobina. FEC e índice de patogenicidade estimada de nematoides nos ovinos foram menores no tratamento SIM. A proporção de Haemonchus spp. foi maior nos sistemas isolados de pastejo. Para os ovinos, os sistemas consorciados apresentaram redução na infecção endoparasitária, sendo SIM melhor que ALT. Para os bovinos, nenhuma diferença entre os sistemas de pastejo foi verificado. Entretanto, o pastejo simultâneo (ovinos e bovinos) pode ser uma ferramenta para reduzir a necessidade de tratamentos anti-helmínticos em ovinos.This experiment was carried out on 8 ha of Panicum maximum cv. Tanzania pastures, with rotational grazing consisting of 7 days of occupation and 21 days of rest. Four treatments were evaluated: cattle grazing alone (BOV), sheep grazing alone (OVI), cattle and sheep grazing simultaneously (SIM) and cattle grazing followed by sheep (alternate - ALT). Twenty heifers and 30 male Santa Inês lambs were used. Fecal egg count (FEC) and fecal cultures were carried out. Blood was also collected to examine red and white cell series, total plasma protein (TPP), albumin and hemoglobin. FEC and estimated nematode pathogenicity index in sheep were lower in the SIM treatment. The Haemonchus spp. proportion was higher in isolated grazing systems. For sheep, mixed grazing was shown to reduce endoparasite infection, and SIM was better than ALT. For cattle, no difference between grazing systems was seen. Therefore, simultaneous grazing (sheep and cattle) may be a tool for reducing the need for anthelmintic treatments in sheep.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Preventive effect of chitosan gel containing CaneCPI-5 against enamel erosive wear in situ.

OBJECTIVE This study evaluated the preventive effect of a chitosan gel containing CaneCPI-5 against enamel erosion and erosion + abrasion in situ. METHODS Sixteen volunteers participated in a crossover, double-blind protocol, comprising 4 phases: (1) no treatment (Nt); (2) chitosan gel (Cg); (3) chitosan gel + 12,300 ppm NaF (Cg + NaF); and (4) chitosan gel + 0.1 mg/mL CaneCPI-5 (Cg + Cane). Volunteers wore an appliance containing 4 specimens. Once/day, they applied the gel (except for Nt) (4 min/specimen). Erosive challenges were performed extra-orally (0.1% citric acid, 90 s, 4 × /day; ERO). Specimens were also abraded (toothbrush, 15 s/specimen, 2 × /day; ERO + ABR). Enamel wear was assessed by profilometry and relative surface reflection intensity (%SRI). Two-way RM-ANOVA/Sidak's tests and Spearman's correlation were used (p < 0.05). RESULTS For profilometry, ERO + ABR promoted significantly greater wear when compared with ERO. There was a significant difference among all treatments. The lowest enamel loss occurred for Cg + Cane, followed by Cg + NaF, Cg, and Nt (p < 0.05). The %SRI was significantly lower for ERO + ABR when compared to ERO, only for the Nt group. The greatest %SRI was found for the Cg + NaF and Cg + Cane groups, which did not differ significantly, regardless of the conditions. The lowest %SRI was found for the Nt and Cg groups, which did not differ from each other, regardless of the conditions. The Nt group did not differ significantly from the Cg + NaF (ERO). There was a significant correlation between both analyses. CONCLUSION The incorporation of CaneCPI-5 in the chitosan gel prevented erosive wear in situ. CLINICAL RELEVANCE These results open a new perspective for the use of CaneCPI-5 in other application vehicles, such as chitosan gel

Nos conocemos

Se desarrolla un proyecto de innovación educativa que pretende reforzar la Educación Intercultural debido al incremento de alumnado inmigrante, y el fomento de la lectura a través de la creatividad. El proyecto abarca a todos los curso de Educación Infantil y Educación Primaria y encamina sus esfuerzos al fomento de la innovación educativa en el ámbito metodológico, tecnológico, organizativo y didáctico, con el fin de añadir valor y calidad a la educación. Se aprovecha la temática 'Cristóbal Colón como nexo de unión entre dos culturas' que se trabaja durante todo el curso escolar como vehículo de formación integral del alumnado. La metodología empleada trata de implicar la acción personal del alumno en un ambiente, con unos contenidos y unos temas que sean significativos y motivadores para desarrollar el esfuerzo necesario que exige todo proceso de aprendizaje. El modelo metodológico utilizado responde al juego, a la globalización y a un aprendizaje constructivista. Se crea un ambiente donde el alumnado se siente seguro para explorar e investigar con la ayuda y asesoramiento del profesor, facilitando el fortalecimiento del autoconcepto y la autoestima mediante la autoevaluación y la autocrítica. Una vez desarrollado el proyecto el alumnado ha tenido la posibilidad de experimentar, vivenciar y acercarse al conocimiento de distintas culturas, entendiendo las actividades como un modo de expresión motivadora y que genera intercambios culturales. El equipo educativo ha abierto vías de comunicación con las familias, fomentando su participación, colaboración y enriquecimiento cultural.Castilla y LeónConsejería de Educación. Dirección General de Universidades e Investigación; Monasterio de Nuestra Señora de Prado, Autovía Puente Colgante s. n.; 47071 Valladolid; +34983411881; +34983411939ES

Aprendizagem e comportamento humano

Neste livro o leitor poderá compreender os processos de aprendizagem e comportamento na vertente pedagógica e clínica, considerando as diferentes pesquisas e reflexões teóricas apresentadas, sustentadas pelas contribuições dos estudos das Habilidades Sociais, dos pressuspostos teóricos da Psicologia Histórico-Cultural e da Análise do Comportamento tendo como pano de fundo a inclusão social e escolar. O livro pode ser um material de consulta importante para pesquisadores e interessados no tem