Designing the E-AODV (E as Enhanced) Routing Protocol to Improvise it during the Nodes or Links Fails

Networks are being used in various areas and the demand of user2019;s nowadays has motivate the emergence of the mobile adhoc network (MANET). In this age of network, most challenging task is to deliver the packet successfully with dynamic network, delay, node and links fails restraint. And to fulfill the above required task, protocol should be used effectively and efficiently .In this paper, we had successfully design the Enhanced-AODV routing protocol which had improvised the performance of AODV and its other several factors like throughput, number of packets delivered, load delay,overhead, packet delivery even in case of frequent path breaks due to nodes or links failure ,dynamic nature etc

Improved likelihood ratio statistic-based cooperative spectrum sensing for cognitive radio

Cooperative spectrum sensing (CSS) is a technique where multiple cognitive radio users cooperate among themselves to make binary decisions about the presence of a primary user. The single cognitive user often faces the hidden terminal problem. However, CSS tackles this problem by sending local sensing-based decisions to the fusion centre. A major drawback of conventional energy detection is the poor performance at low SNR regime. In this work, likelihood ratio statistics is considered as a test-statistic due to its highest statistical power. An improved likelihood ratio statistic-based CSS scheme is proposed by considering several past sensing events. The proposed scheme mitigates the poor detection at low SNR regime and misdetections arising due to sudden drops in signal energy. Furthermore, the generalised Byzantine attack is taken into account considering a security aspect. The proposed scheme is also shown to outperform Anderson Darling-based malicious user detection in CSS at a low SNR regime. The proposed scheme is verified and validated over empirical spectrum data. The performance improvement is at the cost of computational time, which in practice is very low and is justified by the significant performance improvements of the proposed scheme at low SNR regime

Monocytes mediate homing of circulating microvesicles to the pulmonary vasculature during low-grade systemic inflammation

Microvesicles (MVs), a plasma membrane-derived subclass of extracellular vesicles, are produced and released into the circulation during systemic inflammation, yet little is known of cell/tissue-specific uptake of MVs under these conditions. We hypothesized that monocytes contribute to uptake of circulating MVs and that their increased margination to the pulmonary circulation and functional priming during systemic inflammation produces substantive changes to the systemic MV homing profile. Cellular uptake of i.v.-injected, fluorescently labelled MVs (J774.1 macrophage-derived) in vivo was quantified by flow cytometry in vascular cell populations of the lungs, liver and spleen of C57BL6 mice. Under normal conditions, both Ly6Chigh and Ly6Clow monocytes contributed to MV uptake but liver Kupffer cells were the dominant target cell population. Following induction of sub-clinical endotoxemia with low-dose i.v. LPS, MV uptake by lung-marginated Ly6Chigh monocytes increased markedly, both at the individual cell level (~2.5-fold) and through substantive expansion of their numbers (~8-fold), whereas uptake by splenic macrophages was unchanged and uptake by Kupffer cells actually decreased (~50%). Further analysis of MV uptake within the pulmonary vasculature using a combined model approach of in vivo macrophage depletion, ex vivo isolated perfused lungs and in vitro lung perfusate cell-based assays, indicated that Ly6Chigh monocytes possess a high MV uptake capacity (equivalent to Kupffer cells), that is enhanced directly by endotoxemia and ablated in the presence of phosphatidylserine (PS)-enriched liposomes and β3 integrin receptor blocking peptide. Accordingly, i.v.-injected PS-enriched liposomes underwent a redistribution of cellular uptake during endotoxemia similar to MVs, with enhanced uptake by Ly6Chigh monocytes and reduced uptake by Kupffer cells. These findings indicate that monocytes, particularly lung-marginated Ly6Chigh subset monocytes, become a dominant target cell population for MVs during systemic inflammation, with significant implications for the function and targeting of endogenous and therapeutically administered MVs, lending novel insights into the pathophysiology of pulmonary vascular inflammation

Comparative evaluation of hypofractionated radiotherapy versus conventionally fractionated radiotherapy for patients with intermediate and high risk prostate cancer

Background: The purpose of this study was to comparatively evaluate an efficacy and toxicity profile of hypofractionated radiotherapy (67.5 Gy in 25 fractions) to conventionally fractionated radiotherapy (78 Gy in 39 fractions) in prostate cancer patients with intermediate and high-risk disease. Materials and methods: From January 2015 to December 2018, 168 patients were randomized to hypofractionated radiation treatment and conventional fractionated radiation treatment schedules of volumetric modulated arc therapy (VMAT) to the prostate and seminal vesicles. All the patients also received androgen deprivation therapy (ADT) and radiation therapy started after ADT. Results: The median (range) follow-up was 51 (31–63) and 53 (33–64) months in the hypofractionated and conventionally fractionated regimes, respectively. The 3-year biochemical no evidence of disease (bNED) rates were 86.9% and 73.8% in the hypofractionated and conventionally fractionated groups, respectively (p = 0.032, significant). The 3-year bNED rates in patients at a high risk [i.e., pretreatment prostate-specific antigen (PSA) > 20 ng/mL, Gleason score ≥ 8, or T ≥ 2 c], were 87.9% and 73.5% (p = 0.007, significant) in the hypofractionated and conventionally fractionated radiotherapy groups, respectively. No statistically significant difference was found for late toxicity between the two groups, with 3-year grade 2 gastrointestinal toxicity rates of 19% and 16.7% and 3-year grade 2 genitourinary toxicity rates of 15.5% and 11.9% in the hypofractionated and conventionally fractionated radiotherapy groups, respectively. Conclusion: Hypofractionated schedule is superior to the conventional fractionation schedule of radiation treatment in terms of bNED in intermediate and high grade prostate cancer patients. Also, the late toxicity is found to be equivalent between the two treatment groups