Assisted Tachyonic Inflation

The model of inflation with a single tachyon field generates larger anisotropy and has difficulties in describing the formation of the Universe . In this paper we consider a model with multi tachyon fields and study the assisted inflationary solution. Our results show that this model satisfies the observation.Comment: 5 pages, no figures, a revised version and reference adde

SU(4) Chiral Quark Model with Configuration Mixing

Chiral quark model with configuration mixing and broken SU(3)\times U(1) symmetry has been extended to include the contribution from c\bar c fluctuations by considering broken SU(4) instead of SU(3). The implications of such a model have been studied for quark flavor and spin distribution functions corresponding to E866 and the NMC data. The predicted parameters regarding the charm spin distribution functions, for example, \Delta c, \frac{\Delta c}{{\Delta \Sigma}}, \frac{\Delta c}{c} as well as the charm quark distribution functions, for example, \bar c, \frac{2\bar c}{(\bar u+\bar d)}, \frac{2 \bar c}{(u+d)} and \frac{(c+ \bar c)}{\sum (q+\bar q)} are in agreement with other similar calculations. Specifically, we find \Delta c=-0.009, \frac{\Delta c}{{\Delta \Sigma}}=-0.02, \bar c=0.03 and \frac{(c+ \bar c)}{\sum (q+\bar q)}=0.02 for the \chiQM parameters a=0.1, \alpha=0.4, \beta=0.7, \zeta_{E866}=-1-2 \beta, \zeta_{NMC}=-2-2 \beta and \gamma=0.3, the latter appears due to the extension of SU(3) to SU(4).Comment: 10 RevTeX pages. Accepted for publication in Phys. Rev.

A mouse model that is immunologically tolerant to reporter and modifier proteins

Reporter proteins have become an indispensable tool in biomedical research. However, exogenous introduction of these reporters into mice poses a risk of rejection by the immune system. Here, we describe the generation, validation and application of a multiple reporter protein tolerant 'Tol' mouse model that constitutively expresses an assembly of shuffled reporter proteins from a single open reading frame. We demonstrate that expression of the Tol transgene results in the deletion of CD8(+) T cells specific for a model epitope, and substantially improves engraftment of reporter-gene transduced T cells. The Tol strain provides a valuable mouse model for cell transfer and viral-mediated gene transfer studies, and serves as a methodological example for the generation of poly-tolerant mouse strains. Bresser and Dijkgraaf et al. develop the 'Tol' strain, a genetically modified mouse model that expresses a range of shuffled reporter and modifier proteins from a single open reading frame. This strain is immunologically tolerant to these reporter and modifier proteins, providing a valuable model system for cell transfer studies and virus-mediated gene transfer studies.Dermatology-oncolog

The Proton Spin and Flavor Structure in the Chiral Quark Model

After a pedagogical review of the simple constituent quark model and deep inelastic sum rules, we describe how a quark sea as produced by the emission of internal Goldstone bosons by the valence quarks can account for the observed features of proton spin and flavor structures. Some issues concerning the strange quark content of the nucleon are also discussed.Comment: 59 pages with table of contents, Lecture delivered at the Schladming Winter School (March 1997), to be published by Springer-Verlag under the title "Computing Particle Properties" (eds. C. B. Lang and H. Gausterer

Tissue patrol by resident memory CD8+ T cells in human skin

Emerging data show that tissue-resident memory T (TRM) cells play an important protective role at murine and human barrier sites. TRM cells in the epidermis of mouse skin patrol their surroundings and rapidly respond when antigens are encountered. However, whether a similar migratory behavior is performed by human TRM cells is unclear, as technology to longitudinally follow them in situ has been lacking. To address this issue, we developed an ex vivo culture system to label and track T cells in fresh skin samples. We validated this system by comparing in vivo and ex vivo properties of murine TRM cells. Using nanobody labeling, we subsequently demonstrated in human ex vivo skin that CD8+ TRM cells migrated through the papillary dermis and the epidermis, below sessile Langerhans cells. Collectively, this work allows the dynamic study of resident immune cells in human skin and provides evidence of tissue patrol by human CD8+ TRM cells.Toxicolog

Light flavor asymmetry of nucleon sea

The light flavor antiquark distributions of the nucleon sea are calculated in the effective chiral quark model and compared with experimental results. The contributions of the flavor-symmetric sea-quark distributions and the nuclear EMC effect are taken into account to obtain the ratio of Drell-Yan cross sections $\sigma^{\mathrm{pD}}/2\sigma^{\mathrm{pp}}$, which can match well with the results measured in the FermiLab E866/NuSea experiment. The calculated results also match the measured $\bar{d}(x)-\bar{u}(x)$ from different experiments, but unmatch the behavior of $\bar{d}(x)/\bar{u}(x)$ derived indirectly from the measurable quantity $\sigma^{\mathrm{pD}}/2\sigma^{\mathrm{pp}}$ by the FermiLab E866/NuSea Collaboration at large $x$. We suggest to measure again $\bar{d}(x)/\bar{u}(x)$ at large $x$ from precision experiments with careful experimental data treatment. We also propose an alternative procedure for experimental data treatment.Comment: 10 pages, 8 figures, final version to appear in EPJ

Spallation reactions. A successful interplay between modeling and applications

The spallation reactions are a type of nuclear reaction which occur in space by interaction of the cosmic rays with interstellar bodies. The first spallation reactions induced with an accelerator took place in 1947 at the Berkeley cyclotron (University of California) with 200 MeV deuterons and 400 MeV alpha beams. They highlighted the multiple emission of neutrons and charged particles and the production of a large number of residual nuclei far different from the target nuclei. The same year R. Serber describes the reaction in two steps: a first and fast one with high-energy particle emission leading to an excited remnant nucleus, and a second one, much slower, the de-excitation of the remnant. In 2010 IAEA organized a worskhop to present the results of the most widely used spallation codes within a benchmark of spallation models. If one of the goals was to understand the deficiencies, if any, in each code, one remarkable outcome points out the overall high-quality level of some models and so the great improvements achieved since Serber. Particle transport codes can then rely on such spallation models to treat the reactions between a light particle and an atomic nucleus with energies spanning from few tens of MeV up to some GeV. An overview of the spallation reactions modeling is presented in order to point out the incomparable contribution of models based on basic physics to numerous applications where such reactions occur. Validations or benchmarks, which are necessary steps in the improvement process, are also addressed, as well as the potential future domains of development. Spallation reactions modeling is a representative case of continuous studies aiming at understanding a reaction mechanism and which end up in a powerful tool.Comment: 59 pages, 54 figures, Revie

Green function techniques in the treatment of quantum transport at the molecular scale

The theoretical investigation of charge (and spin) transport at nanometer length scales requires the use of advanced and powerful techniques able to deal with the dynamical properties of the relevant physical systems, to explicitly include out-of-equilibrium situations typical for electrical/heat transport as well as to take into account interaction effects in a systematic way. Equilibrium Green function techniques and their extension to non-equilibrium situations via the Keldysh formalism build one of the pillars of current state-of-the-art approaches to quantum transport which have been implemented in both model Hamiltonian formulations and first-principle methodologies. We offer a tutorial overview of the applications of Green functions to deal with some fundamental aspects of charge transport at the nanoscale, mainly focusing on applications to model Hamiltonian formulations.Comment: Tutorial review, LaTeX, 129 pages, 41 figures, 300 references, submitted to Springer series "Lecture Notes in Physics

Inelastic Rescattering and CP Asymmetries in D -> pi+ pi-, pi0 pi0

We study the direct CP violation induced by inelastic final state interaction (FSI) rescattering in $D\to\pi\pi$ modes, and find that the resultant CP asymmetry is about $10^{-4}$ which is larger than $\epsilon'$ in the K-system. Our estimation is based on well-established theories and experiment measured data, so there are almost no free parameters except the weak phase $\delta_{13}$ in the CKM matrix.Comment: 9 page

Eta Meson Production in NN Collisions

Eta meson production in both proton-proton and proton-neutron collisions is investigated within a relativistic meson exchange model of hadronic interactions. It is found that the available cross section data can be described equally well by either the vector or pseudoscalar meson exchange mechanism for exciting the S_{11}(1535) resonance. It is shown that the analyzing power data can potentially be very useful in distinguishing these two scenarios for the excitaion of the S_{11}(1535) resonance.Comment: Revtex, 35 pages, 8 figure