An Etude on Recursion Relations and Triangulations

Following~\cite{Arkani-Hamed:2017thz}, we derive a recursion relation by applying a one-parameter deformation of kinematic variables for tree-level scattering amplitudes in bi-adjoint $\phi^3$ theory. The recursion relies on properties of the amplitude that can be made manifest in the underlying kinematic associahedron, and it provides triangulations for the latter. Furthermore, we solve the recursion relation and present all-multiplicity results for the amplitude: by reformulating the associahedron in terms of its vertices, it is given explicitly as a sum of "volume" of simplicies for any triangulation, which is an analogy of BCFW representation/triangulation of amplituhedron for ${\cal N}=4$ SYM.Comment: 26 pages, 3 figure

An Etude on Recursion Relations and Triangulations

Following~\cite{Arkani-Hamed:2017thz}, we derive a recursion relation by applying a one-parameter deformation of kinematic variables for tree-level scattering amplitudes in bi-adjoint $\phi^3$ theory. The recursion relies on properties of the amplitude that can be made manifest in the underlying kinematic associahedron, and it provides triangulations for the latter. Furthermore, we solve the recursion relation and present all-multiplicity results for the amplitude: by reformulating the associahedron in terms of its vertices, it is given explicitly as a sum of "volume" of simplicies for any triangulation, which is an analogy of BCFW representation/triangulation of amplituhedron for ${\cal N}=4$ SYM.Comment: 26 pages, 3 figure

Notes on cluster algebras and some all-loop Feynman integrals

We study cluster algebras for some all-loop Feynman integrals, including box-ladder, penta-box-ladder, and (seven-point) double-penta-ladder integrals. In addition to the well-known box ladder whose symbol alphabet is $D_2\simeq A_1^2$, we show that penta-box ladder has an alphabet of $D_3\simeq A_3$ and provide strong evidence that the alphabet of double-penta ladder can be identified with a $D_4$ cluster algebra. We relate the symbol letters to the ${\bf u}$ variables of cluster configuration space, which provide a gauge-invariant description of the cluster algebra, and we find various sub-algebras associated with limits of the integrals. We comment on constraints similar to extended-Steinmann relations or cluster adjacency conditions on cluster function spaces. Our study of the symbol and alphabet is based on the recently proposed Wilson-loop ${\rm d}\log$ representation, which allows us to predict higher-loop alphabet recursively; by applying such recursions to six-dimensional hexagon integrals, we also find $D_5$ and $D_6$ cluster functions for the two-mass-easy and three-mass-easy case, respectively.Comment: 28 pages, several figures; v2: typos corrected, functions of ladder integrals computed to higher loops; v3: more examples of double-penta-ladder integrals and discussions about their alphabet adde

Bootstrapping octagons in reduced kinematics from A2A_2 cluster algebras

Multi-loop scattering amplitudes/null polygonal Wilson loops in ${\mathcal N}=4$ super-Yang-Mills are known to simplify significantly in reduced kinematics, where external legs/edges lie in an $1+1$ dimensional subspace of Minkowski spacetime (or boundary of the $\rm AdS_3$ subspace). Since the edges of a $2n$-gon with even and odd labels go along two different null directions, the kinematics is reduced to two copies of $G(2,n)/T \sim A_{n{-}3}$. In the simplest octagon case, we conjecture that all loop amplitudes and Feynman integrals are given in terms of two overlapping $A_2$ functions (a special case of two-dimensional harmonic polylogarithms): in addition to the letters $v, 1+v, w, 1+w$ of $A_1 \times A_1$, there are two letters $v-w, 1- v w$ mixing the two sectors but they never appear together in the same term; these are the reduced version of four-mass-box algebraic letters. Evidence supporting our conjecture includes all known octagon amplitudes as well as new computations of multi-loop integrals in reduced kinematics. By leveraging this alphabet and conditions on first and last entries, we initiate a bootstrap program in reduced kinematics: within the remarkably simple space of overlapping $A_2$ functions, we easily obtain octagon amplitudes up to two-loop NMHV and three-loop MHV. We also briefly comment on the generalization to $2n$-gons in terms of $A_2$ functions and beyond.Comment: 26 pages, several figures and tables, an ancilary fil

Feynman Integrals and Scattering Amplitudes from Wilson Loops

We study Feynman integrals and scattering amplitudes in ${\cal N}=4$ super-Yang-Mills by exploiting the duality with null polygonal Wilson loops. Certain Feynman integrals, including one-loop and two-loop chiral pentagons, are given by Feynman diagrams of a supersymmetric Wilson loop, where one can perform loop integrations and be left with simple integrals along edges. As the main application, we compute analytically for the first time, the symbol of the generic ($n\geq 12$) double pentagon, which gives two-loop MHV amplitudes and components of NMHV amplitudes to all multiplicities. We represent the double pentagon as a two-fold $\mathrm{d} \log$ integral of a one-loop hexagon, and the non-trivial part of the integration lies at rationalizing square roots contained in the latter. We obtain a remarkably compact "algebraic words" which contain $6$ algebraic letters for each of the $16$ square roots, and they all nicely cancel in combinations for MHV amplitudes and NMHV components which are free of square roots. In addition to $96$ algebraic letters, the alphabet consists of $152$ dual conformal invariant combinations of rational letters.Comment: 8 pages, 4 figures, 1 ancillary file; v3: important updates, a compact form for the symbol of double pentagon integral added; typos correcte

On symbology and differential equations of Feynman integrals from Schubert analysis

We take the first step in generalizing the so-called "Schubert analysis", originally proposed in twistor space for four-dimensional kinematics, to the study of symbol letters and more detailed information on canonical differential equations for Feynman integral families in general dimensions with general masses. The basic idea is to work in embedding space and compute possible cross-ratios built from (Lorentz products of) maximal cut solutions for all integrals in the family. We demonstrate the power of the method using the most general one-loop integrals, as well as various two-loop planar integral families (such as sunrise, double-triangle and double-box) in general dimensions. Not only can we obtain all symbol letters as cross-ratios from maximal-cut solutions, but we also reproduce entries in the canonical differential equations satisfied by a basis of dlog integrals.Comment: 51 pages, many figure

Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation

We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling

A previously unappreciated deubiquitinase activity of MCP-induced protein 1 contributes to its role in dampening inflammatory signaling