784 research outputs found
Behaviour of adenylic and pyridinic compounds in gingival tissue after a short-term exposure to air
Biochemical variations of adenine and pyridine compounds in human gingival grafts during the period between excision and implantation have been studied. These groups of compounds are considered as «indicators» of the metabolic and energetic status of the living cells. Adenylic compounds such as ATP, ADP and AMP are involved in numerous metabolic processes as «modulators» of allosteric enzymes.NAD+ and NADP+ are involved in the carbohydrate metabolism as co-factors of many reactions of oxydoreduction. The exposure to air of the gingival tissue induces modifications in the energy state of the cells as well as in the ox-reox system. No variation is detectable in the intermediates of the pyridine compounds cycle.Dans des gencives humaines prĂ©levĂ©es pour des greffes, ont Ă©tĂ© Ă©tudiĂ©es, Ă certains intervalles de temps entre le prĂ©lĂšvement et la greffe, les variations biochimiques des composĂ©s adĂ©nyliques et pyridiniques, qui sont les «indicateurs» des conditions Ă©nergĂ©tiques et mĂ©taboliques du tissu. Des composĂ©s comme lâATP, lâADP et lâAMP participent Ă de nombreux processus mĂ©taboliques comme «modulateurs» des enzymes allostĂ©riques. NAD+ et NADP + participent au mĂ©tabolisme des carbohydrates comme co-facteurs de nombreuses rĂ©actions dâoxydorĂ©duction. Une brĂšve exposition de la gencive Ă lâair provoque des changements dans le mĂ©tabolisme des cellules et du systĂšme dâoxydorĂ©duction. Il nây a pas de variation notable dans les composĂ©s intermĂ©diaires du cycle pyridinique
Predicting users' first impressions of website aesthetics with a quantification of perceived visual complexity and colorfulness
Users make lasting judgments about a website's appeal within a split second of seeing it for the first time. This first impression is influential enough to later affect their opinions of a site's usability and trustworthiness. In this paper, we demonstrate a means to predict the initial impression of aesthetics based on perceptual models of a website's colorfulness and visual complexity. In an online study, we collected ratings of colorfulness, visual complexity, and visual appeal of a set of 450 websites from 548 volunteers. Based on these data, we developed computational models that accurately measure the perceived visual complexity and colorfulness of website screenshots. In combination with demographic variables such as a user's education level and age, these models explain approximately half of the variance in the ratings of aesthetic appeal given after viewing a website for 500ms only.Engineering and Applied Science
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The Envelope Thermal Test Unit (ETTU): Full Measurement of WallPerform ance
There are many ways of calculating the dynamic thermal performance of walls and many ways of measuring the performance of walls in the laboratory, relatively few field measurements have been made of the dynamic performance of wall in situ. Measuring the thermal performance of walls in situ poses two separate problems: measuring the heat fluxes and surface temperatures of the wall, and reducing this data set into usable parameters. We have solved the first problem by developing the Envelope Thermal Test Unit (ETTU). ETTU consists of two specially constructed polystyrene blankets, 1.2m square, placed on either side of the test wall that both control and measure the surface fluxes and surface temperatures of the wall. To solve the second problem we have developed a simplified dynamic model that describes the thermal performance of a wall in terms of its steady-state conductance, a time constant, and some storage terms. We have used ETTU in the field to measure the thermal performance of walls, and have applied our simplified analysis to calculate simplified thermal parameters from this data set. In this report, we present the in-situ measurements made to date using ETTU, and the resulting model predictions. The agreement between measured and predicted surface fluxes demonstrates the ability of our test unit and analytic model to describe the dynamic performance of walls in situ
Biosynthesis of Mitochondrial Porin and Insertion into the Outer Mitochondrial Membrane of Neuruspora crassa
Mitochondrial porin, the major protein of the outer mitochondrial membrane is synthesized by free cytoplasmic polysomes. The apparent molecular weight of the porin synthesized in homologous or heterologous cell-free systems is the same as that of the mature porin. Transfer in vitro of mitochondrial porin from the cytosolic fraction into the outer membrane of mitochondria could be demonstrated. Before membrane insertion, mitochondrial porin is highly sensitive to added proteinase; afterwards it is strongly protected. Binding of the precursor form to mitochondria occurs at 4°C and appears to precede insertion into the membrane. Unlike transfer of many precursor proteins into or across the inner mitochondrial membrane, assembly of the porin is not dependent on an electrical potential across the inner membrane
The Vector Probe in Heavy-Ion Reactions
We review essential elements in using the channel as a probe for
hot and dense matter as produced in (ultra-) relativistic collisions of heavy
nuclei. The uniqueness of the vector channel resides in the fact that it
directly couples to photons, both real and virtual (dileptons), enabling the
study of thermal radiation and in-medium effects on both light () and heavy () vector mesons. We emphasize the importance
of interrelations between photons and dileptons, and characterize relevant
energy/mass regimes through connections to Quark-Gluon-Plasma emission and
chiral symmetry restoration. Based on critical analysis of our current
understanding of data from fixed-target energies, we identify open key
questions to be addressed.Comment: Invited Talk at the Hot Quarks 2004 Workshop, July 18-24, 2004 (Taos
Valley, NM, USA), 15 pages latex incl 14 figs and iop style files, to appear
in the proceeding
Different Transport Pathways of Individual Precursor Proteins in Mitochondria
Transport of mitochondrial precursor proteins into mitochondria of Neurospora crassa was studied in a cellfree reconstituted system. Precursors were synthesized in a reticulocyte lysate programmed with Neurospora mRNA and transported into isolated mitochondria in the absence of protein synthesis. Uptake of the following precursors was investigated: apocytochrome c, ADP/ATP carrier and subunit 9 of the oligomycin-sensitive ATPase.
Addition of high concentrations of unlabelled chemically prepared apocytochrome c (1â10 ÎŒM) inhibited the appearance in the mitochondrial of labelled cytochrome c synthesized in vitro because the unlabelled protein dilutes the labelled one and because the translocation system has a limited capacity [apparent V is 1â3 pmol Ă minâ1Ă (mg mitochondrial protein)â1]. Concentrations of added apocytochrome c exceeding the concentrations of precursor proteins synthesized in vitro by a factor of about 104 did not inhibit the transfer of ADP/ATP carrier or ATPase subunit 9 into mitochondria. Carbonylcyanide m-chlorophenylhydrazone, an uncoupler of oxidative phosphorylation, inhibited transfer in vitro of ADP/ATP carrier and of ATPase subunit 9, but not of cytochrome c.
These findings suggest that cytochrome c and the other two proteins have different import pathways into mitochondria. It can be inferred from the data presented that different 'receptors' on the mitochondrial surface mediate the specific recognition of precursor proteins by mitochondria as a first step in the transport process
Study of dimuon production in Indium-Indium collisions with the NA60 experiment
The NA60 experiment at the CERN-SPS is devoted to the study of dimuon
production in heavy-ion and proton-nucleus collisions. We present preliminary
results from the analysis of Indium-Indium collisions at 158 GeV per nucleon.
The topics covered are low mass vector meson production, J/psi production and
suppression, and the feasibility of the open charm measurement from the dimuon
continuum in the mass range below the J/psi peak.Comment: Contribution at XXXXth Rencontres de Moriond, "QCD and High Energy
Hadronic Interactions
Latest results from NA60
The NA60 experiment has measured the production of muon pairs and of charged
particles in In+In collisions at a beam energy of 158 AGeV. For invariant
dimuon masses below the phi the space-time averaged rho spectral function was
isolated by a novel procedure. It shows a strong broadening but essentially no
shift in mass. The production of J/psi was measured as a function of the
collision centrality. As in previous experiments studying Pb+Pb collisions an
anomalous supression is observed, setting in at approximately 90 participant
nucleons. Using the charged particles the reaction plane was reconstructed. The
elliptic flow of charged particles increases with pt showing a saturation for
pt > 2GeV/c. For the first time azimuthal distributions for J/psi are shown.Comment: 9 pages, 11 figures, talk given at the conference "Strangeness in
Quark Matter 2006 (SQM2006)", March 2006, Los Angeles, USA, accepted for
publication in Journal of Physics
Strangeness Report
The paper provides a short report on strangeness production in
ultrarelativistic nucleus-nucleus collision, with the main stress on strange
particle abundances.Comment: Proceedings of Quark Matter 200
Evidence for radial flow of thermal dileptons in high-energy nuclear collisions
The NA60 experiment at the CERN SPS has studied low-mass dimuon production in
158 AGeV In-In collisions. An excess of pairs above the known meson decays has
been reported before. We now present precision results on the associated
transverse momentum spectra. The slope parameter Teff extracted from the
spectra rises with dimuon mass up to the rho, followed by a sudden decline
above. While the initial rise is consistent with the expectations for radial
flow of a hadronic decay source, the decline signals a transition to an
emission source with much smaller flow. This may well represent the first
direct evidence for thermal radiation of partonic origin in nuclear collisions.Comment: Accepted for publication in Physical Review Letter
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