Thermotunnel refrigerator with vacuum/insulator tunnel barrier: A theoretical analysis

The authors use two insulator layers in thermotunnel refrigerator to modify the shape of the tunneling barrier so that electrons with high kinetic energy pass it with increased probability. Theoretical analysis show that the overall tunneling current between the electrodes contains an increased number of high kinetic energy electrons and a reduced number of low energy ones, leading to high efficiency. The particular case of vacuum gap and solid insulator layer is calculated using digital methods. Efficiency remains high in the wide range of the emitter electric field. The cooling coefficient is found to be as high as 40%-50% in the wide range of the emitter electric field.Comment: 9 pages, 3 figure

Chemokine Receptors and Phagocyte Biology in Zebrafish

Phagocytes are highly motile immune cells that ingest and clear microbial invaders, harmful substances, and dying cells. Their function is critically dependent on the expression of chemokine receptors, a class of G-protein-coupled receptors (GPCRs). Chemokine receptors coordinate the recruitment of phagocytes and other immune cells to sites of infection and damage, modulate inflammatory and wound healing responses, and direct cell differentiation, proliferation, and polarization. Besides, a structurally diverse group of atypical chemokine receptors (ACKRs) are unable to signal in G-protein-dependent fashion themselves but can shape chemokine gradients by fine-tuning the activity of conventional chemokine receptors. The optically transparent zebrafish embryos and larvae provide a powerful in vivo system to visualize phagocytes during development and study them as key elements of the immune response in real-time. In this review, we discuss how the zebrafish model has furthered our understanding of the role of two main classes of chemokine receptors, the CC and CXC subtypes, in phagocyte biology. We address the roles of the receptors in the migratory properties of phagocytes in zebrafish models for cancer, infectious disease, and inflammation. We illustrate how studies in zebrafish enable visualizing the contribution of chemokine receptors and ACKRs in shaping self-generated chemokine gradients of migrating cells. Taking the functional antagonism between two paralogs of the CXCR3 family as an example, we discuss how the duplication of chemokine receptor genes in zebrafish poses challenges, but also provides opportunities to study sub-functionalization or loss-of-function events. We emphasize how the zebrafish model has been instrumental to prove that the major determinant for the functional outcome of a chemokine receptor-ligand interaction is the cell-type expressing the receptor. Finally, we highlight relevant homologies and analogies between mammalian and zebrafish phagocyte function and discuss the potential of zebrafish models to further advance our understanding of chemokine receptors in innate immunity and disease

Not eating like a pig: European wild boar wash their food

Carrying food to water and either dunking or manipulating it before consumption has been observed in various taxa including birds, racoons and primates. Some animals seem to be simply moistening their food. However, true washing aims to remove unpleasant surface substrates such as grit and sand and requires a distinction between items that do and do not need cleaning as well as deliberate transportation of food to a water source. We provide the first evidence for food washing in suids, based on an incidental observation with follow-up experiments on European wild boar (Sus scrofa) kept at Basel Zoo, Switzerland. Here, all adult pigs and some juveniles of a newly formed group carried apple halves soiled with sand to the edge of a creek running through their enclosure where they put the fruits in the water and pushed them to and fro with their snouts before eating. Clean apple halves were never washed. This indicates that pigs can discriminate between soiled and unsoiled foods and that they are able to delay gratification for long enough to transport and wash the items. However, we were unable to ascertain to which degree individual and/or social learning brought this behaviour about

Interrogating Boundaries against Animals and Machines: Human Speciesism in British Newspapers

Humans favor and venerate their ingroups, while disregarding outgroups to the degree of dehumanizing them. We explore the social construction of such boundaries and its associated speciesism toward two nonhuman outgroups: animals and machines. For this, we analyzed UK newspaper coverages of the binaries Human–Animal and Human–Machine between 1995 and 2010. We quantified if and how tolerance toward ambiguous concepts that challenge and expand definitions of humanness (e.g., nonhuman primates, cyborgs) varied across time as well as with journalist gender, political leaning, and expertise. In this analysis, the ca. 1100 individual journalists stood as proxies for the British public and therefore as a human-ingroup subset. We found more tolerance toward intermediaries in broadsheet newspapers, females, and subject experts, as opposed to tabloids, males, and subject novices. Moreover, ambiguity tolerance hit a low during the year 2000, likely due to Western sociopolitical turbulence—potentially including wider societal stress over the landmark millennium year itself—attesting that ingroups become more closed during stressful times. Compared with the plasticity of the Human–Animal dichotomy, the Human–Machine binary was more rigid, indicating that the relative novelty of IT developments triggers increased caution and anxiety. Our research suggests that cognitive mechanisms facilitating human-ingroup protection are deep-rooted, albeit malleable according to changing socioeconomic conditions

The flux distribution of the three quark system in SU(3)

We study the abelian color-flux distribution of the three quark system in the maximally abelian gauge on SU(3) lattices. The distribution of the color electric field suggests $Y Ansatz$, which might be interpreted through the dual superconductor picture as the result of the vacuum pressure in the confined phase. In order to clarify the flux structure, we investigate the color electric field in the three quark system also in the monopole part and in the photon part.Comment: 3pages, 5figures, Lattice2002(topology

Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence

Enteric and sympathetic neurons have previously been proposed to be lineally related. We present independent lines of evidence that suggest that enteric neurons arise from at least two lineages, only one of which expresses markers in common with sympathoadrenal cells. In the rat, sympathoadrenal markers are expressed, in the same order as in sympathetic neurons, by a subset of enteric neuronal precursors, which also transiently express tyrosine hydroxylase. If this precursor pool is eliminated in vitro by complement-mediated lysis, enteric neurons continue to develop; however, none of these are serotonergic. In the mouse, the Mash-1−/− mutation, which eliminates sympathetic neurons, also prevents the development of enteric serotonergic neurons. Other enteric neuronal populations, however, including those that contain calcitonin gene related peptide are present. Enteric tyrosine hydroxylase-containing cells co-express Mash-1 and are eliminated by the Mash-1−/− mutation, consistent with the idea that in the mouse, as in the rat, these precursors generate serotonergic neurons. Serotonergic neurons are generated early in development, while calcitonin gene related peptide-containing enteric neurons are generated much later. These data suggest that enteric neurons are derived from at least two progenitor lineages. One transiently expresses sympathoadrenal markers, is Mash-1-dependent, and generates early-born enteric neurons, some of which are serotonergic. The other is Mash-1-independent, does not express sympathoadrenal markers, and generates late-born enteric neurons, some of which contain calcitonin gene related peptide

Evolution of the Mass-Metallicity relations in passive and star-forming galaxies from SPH-cosmological simulations

We present results from SPH-cosmological simulations, including self-consistent modelling of SN feedback and chemical evolution, of galaxies belonging to two clusters and twelve groups. We reproduce the mass-metallicity (ZM) relation of galaxies classified in two samples according to their star-forming activity, as parametrized by their sSFR, across a redshift range up to z=2. Its slope shows irrelevant evolution in the passive sample, being steeper in groups than in clusters. However, the sub-sample of high-mass passive galaxies only is characterized by a steep increase of the slope with redshift, from which it can be inferred that the bulk of the slope evolution of the ZM relation is driven by the more massive passive objects. (...ABRIDGED...) The ZM relation for the star-forming sample reveals an increasing scatter with redshift, indicating that it is still being built at early epochs. The star-forming galaxies make up a tight sequence in the SFR-M_* plane at high redshift, whose scatter increases with time alongside with the consolidation of the passive sequence. We also confirm the anti-correlation between sSFR and stellar mass, pointing at a key role of the former in determining the galaxy downsizing, as the most significant means of diagnostics of the star formation efficiency. Likewise, an anti-correlation between sSFR and metallicity can be established for the star-forming galaxies, while on the contrary more active galaxies in terms of simple SFR are also metal-richer. We discuss these results in terms of the mechanisms driving the evolution within the high- and low-mass regimes at different epochs: mergers, feedback-driven outflows and the intrinsic variation of the star formation efficiency.Comment: Emended list of author

Nambu representation of an extended Lorenz model with viscous heating

We consider the Nambu and Hamiltonian representations of Rayleigh-Benard convection with a nonlinear thermal heating effect proportional to the Eckert number (Ec). The model we use is an extension of the classical Lorenz-63 model with 4 kinematic and 6 thermal degrees of freedom. The conservative parts of the dynamical equations which include all nonlinearities satisfy Liouville's theorem and permit a conserved Hamiltonian H for arbitrary Ec. For Ec=0 two independent conserved Casimir functions exist, one of these is associated with unavailable potential energy and is also present in the Lorenz-63 truncation. This Casimir C is used to construct a Nambu representation of the conserved part of the dynamical system. The thermal heating effect can be represented either by a second canonical Hamiltonian or as a gradient (metric) system using the time derivative of the Casimir. The results demonstrate the impact of viscous heating in the total energy budget and in the Lorenz energy cycle for kinetic and available potential energy.Comment: 15 pages, no figur

Identifying Urban Sources as Cause of Elevated Grass Pollen Concentrations using GIS and Remote Sensing

We examine here the hypothesis that during flowering, the grass pollen concentrations at a specific site reflect the distribution of grass pollen sources within a few kilometres of this site.We perform this analysis on data from a measurement campaign in the city of Aarhus (Denmark) using three pollen traps and by comparing these observations with a novel inventory of grass pollen sources. The source inventory is based on a new methodology developed for urbanscale grass pollen sources. The new methodology is believed to be generally applicable for the European area, as it relies on commonly available remote sensing data combined with management information for local grass areas. The inventory has identified a number of grass pollen source areas present within the city domain. The comparison of the measured pollen concentrations with the inventory shows that the atmospheric concentrations of grass pollen in the urban zone reflect the source areas identified in the inventory, and that the pollen sources that are found to affect the pollen levels are located near or within the city domain. The results also show that during days with peak levels of pollen concentrations there is no correlation between the three urban traps and an operational trap located just 60 km away. This finding suggests that during intense flowering, the grass pollen concentration mirrors the local source distribution and is thus a local-scale phenomenon. Model simulations aimed at assessing population exposure to pollen levels are therefore recommended to take into account both local sources and local atmospheric transport, and not to rely only on describing regional to long-range transport of pollen. The derived pollen source inventory can be entered into local-scale atmospheric transport models in combination with other components that simulate pollen release in order to calculate urban-scale variations in the grass pollen load. The gridded inventory with a resolution of 14m is therefore made available as supplementary material to this paper, and the verifying grass pollen observations are additionally available in tabular form