43 research outputs found

    Corruption and Embedded Autonomy: A Cross-National Analysis of Forest Loss

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    Previous research finds that the influences of colonial heritage on cultural norms and practices may have an effect on corruption levels. On the one hand, researchers argue that former colonies have higher levels of perceived corruption, due to the patrimonial systems colonizers set up. Others argue that the different legal systems colonizers imposed on nations are more susceptible to corruption than others, and some find this effect diminishes over time or where colonizers remained a minority. Moreover, scholars also suggest that non-colonized nations do not have the legal structures, political stability, and support from colonizers, and thus have higher levels of corruption. While this previous research contributes to our understanding of corruption as embedded in larger, historical structures, it does not consider how colonial processes shape how corruption impacts material outcomes in nations. Building on this previous research, the present study uses ordinary least squares regression (OLS) for a sample of 95 low- and middle-income nations from 2001 to 2014 to test how the impact of colonial forces, measured as domestic and international autonomy (the extent to which a nation is free of the direct control of external political actors), moderates the effect of corruption on forest loss

    Corrupt Actions and Forest Loss: A Cross-National Analysis

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    Extant literature documents the negative environmental impacts of corruption on forest loss. More recently, research has shown that both grand and petty corruption are associated with higher levels of forest loss in low- and middle-income nations. However, the extant research neglects to assess how different types of grand and petty corruption impact forest loss. To address the gap in the literature, this article differentiates the effect of various types of corrupt actions on forest loss. Ordinary Least Squares (OLS) regression for a sample of 87 low- and middle-income nations from 2000 is used to test if grand corrupt actions, namely embezzlement and bribes, and petty corrupt actions including theft and corrupt exchanges are related to increased forest loss. The dependent variable uses satellite forest data from 2001 to 2014. Results show that embezzlement, bribes, theft, and corrupt exchanges all impact forest loss, which suggests that policy measures to curb corruption should take a holistic approach to corruption, rather than rely on individual interventions

    Do China’s Environmental Gains at Home Fuel Forest Loss Abroad?: A Cross-National Analysis

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    The theory and empirical research on ecologically unequal exchange serves as the starting point for this study. We expand the research frontier it in a novel way by applying the theory to China and empirically testing if forestry export flows from low-and middle-income nations to China  are related to increased forest loss in the exporting nations. In doing so, we analyze data for 75 low-and middle-income nations using ordinary least squares regression and find support for our main hypothesis

    Marketing and Outreach in Law Libraries: A White Paper

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    In recent years, libraries have turned to marketing and outreach to better educate library users about services and resources while gaining an understanding of their needs. Marketing and outreach are relatively new concepts in academic law libraries, and librarians tasked with these functions have found resources and examples of this type of work to be lacking. Though focused on academic law libraries, the article identifies the challenges facing all law libraries, explains why libraries need marketing and outreach plans, and provides examples of marketing and outreach successes

    DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells

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    BACKGROUND: Induced pluripotent stem (iPS) cells have the capability to undergo self-renewal and differentiation into all somatic cell types. Since they can be produced through somatic cell reprogramming, which uses a defined set of transcription factors, iPS cells represent important sources of patient-specific cells for clinical applications. However, before these cells can be used in therapeutic designs, it is essential to understand their genetic stability.\ud \ud METHODOLOGY/PRINCIPAL FINDINGS: Here, we describe DNA damage responses in human iPS cells. We observe hypersensitivity to DNA damaging agents resulting in rapid induction of apoptosis after γ-irradiation. Expression of pluripotency factors does not appear to be diminished after irradiation in iPS cells. Following irradiation, iPS cells activate checkpoint signaling, evidenced by phosphorylation of ATM, NBS1, CHEK2, and TP53, localization of ATM to the double strand breaks (DSB), and localization of TP53 to the nucleus of NANOG-positive cells. We demonstrate that iPS cells temporary arrest cell cycle progression in the G(2) phase of the cell cycle, displaying a lack of the G(1)/S cell cycle arrest similar to human embryonic stem (ES) cells. Furthermore, both cell types remove DSB within six hours of γ-irradiation, form RAD51 foci and exhibit sister chromatid exchanges suggesting homologous recombination repair. Finally, we report elevated expression of genes involved in DNA damage signaling, checkpoint function, and repair of various types of DNA lesions in ES and iPS cells relative to their differentiated counterparts.\ud \ud CONCLUSIONS/SIGNIFICANCE: High degrees of similarity in DNA damage responses between ES and iPS cells were found. Even though reprogramming did not alter checkpoint signaling following DNA damage, dramatic changes in cell cycle structure, including a high percentage of cells in the S phase, increased radiosensitivity and loss of DNA damage-induced G(1)/S cell cycle arrest, were observed in stem cells generated by induced pluripotency.\ud \u

    Mitochondrial physiology

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    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Mitochondrial physiology

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    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

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    Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

    Can democracy reduce forest loss?: A cross-national analysis

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    While democracies are thought to have the power, authority, and ability to make significant reductions in forest loss, cross-national research yields contradictory findings. Previous research finds that democracy increases forest loss, decreases forest loss, and has no impact on forest loss. This article argues that these mixed findings are because within democracies, institutional structures of governance vary. While some democracies may have strong governance, others may not, which may explain contradictory findings in previous research. To test this claim, this article includes an interaction term between four measures of democracy (polyarchy, vertical, diagonal, and horizontal) and three national governance measures (i.e., control of corruption, rule of law, and government effectiveness) using ordinary least squares (OLS) regression for a sample of 86 low‐ and middle‐income nations. The dependent variable is the change in forest loss from 2001 to 2014. The findings suggest that democracy decreases forest loss more at higher levels of governance than lower levels of governance. These results suggest that democracies alone will not reduce forest loss, but that democracies with strong governance can reduce forest loss
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