Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review

A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on individual observations. A standard integration task in cancer studies is to identify altered genomic regions that induce changes in the expression of the associated genes based on joint analysis of genome-wide gene expression and copy number profiling measurements. In this review, we provide a comparison among various modeling procedures for integrating genome-wide profiling data of gene copy number and transcriptional alterations and highlight common approaches to genomic data integration. A transparent benchmarking procedure is introduced to quantitatively compare the cancer gene prioritization performance of the alternative methods. The benchmarking algorithms and data sets are available at http://intcomp.r-forge.r-project.orgComment: PDF file including supplementary material. 9 pages. Preprin

Kortlægning af trafikal luftforurening og virkemiddelkatalog for Frederiksberg Kommune: Artikel

DCE – Nationalt Center for Miljø og Energi, Aarhus Universitet har for Frederiksberg Kommune udarbejdet en kortlægning af luftforurening (Jensen et al., 2020a) og et virkemiddelkatalog for forbedring af luftkvaliteten (Jensen et al., 2020b). De to rapporter indgår som fagligt baggrundsmateriale for Frederiksberg Kommunes egen formulering af en luftforureningsstrategi - STRATEGI FOR REN LUFT – 2030, som blev udgivet i august 2021 (Frederiksberg Kommune, 2021). Artiklen beskriver kortlægningen af luftforureningen i Frederiksberg Kommune og dens helbredsmæssige konsekvenser. Kortlægningen indeholder en luftkvalitetsvurdering med geografisk beskrivelse af luftkvaliteten; en kildeopgørelse, som beskriver emissionen fordelt på kilder, og kildernes bidrag til luftkvaliteten; samt luftforureningens helbredseffekter og tilhørende samfundsmæssige omkostninger (eksterne omkostninger). Endvidere præsenteres et virkemiddelkatalog for reduktion af luftforurening i Frederiksberg Kommune med fokus på kommunale virkemidler inden for trafik, og en konsekvensvurdering af virkemidlerne. Virkemidler beskrives inden for indsatsområderne: By- og trafikplanlægning, elektrificering af transport, økonomiske virkemidler og regulering af transport, samt ikke-kildebaserede virkemidlers rensning af miljøet. Væsentlige lokale kilder til luftforurening er trafik og brændeovne, hvor denne artiklen alene omhandler trafik

Struggling for recognition and inclusion—parents' and pupils' experiences of special support measures in school

During the last decade an increasing use of differentiated support measures for pupils with special educational needs, indicative of a discrepancy between educational policies and practices, has been witnessed in Sweden. Another trend has been the increased use of medical diagnoses in school. The aim of this study was to explore the main concern of support given to pupils with special educational needs and how pupils and parents experience and handle this. Interviews were conducted with eight pupils in Grades 7–9—and their parents—at two compulsory schools in a city in northern Sweden. A grounded theory approach was used for analyzing the interview data. A conceptual model was generated illuminating the main concern of special support measures for pupils and parents. The core category of the model, struggling for recognition and inclusion, was related to two categories, which further described how this process was experienced and handled by the participants. These categories were labeled negotiating expertise knowledge within a fragmented support structure and coping with stigma, ambivalence, and special support measures. The developed conceptual model provides a deeper understanding of an ongoing process of struggle for recognition and inclusion in school as described by the pupils and parents

Long-Term Exposure to Traffic-Related Air Pollution Associated with Blood Pressure and Self-Reported Hypertension in a Danish Cohort

Background: Short-term exposure to air pollution has been associated with changes in blood pressure (BP) and emergency department visits for hypertension, but little is known about the effects of long-term exposure to traffic-related air pollution on BP and hypertension