The value of physical education for preschool children

Preschool age is extremely important in a person's life. In this period lay the Foundation of health, start to develop various ability, formed the moral quality develop traits. On how the child is brought up in these years, largely determines its future, the effectiveness of schooling, the subsequent formation of the personalityДошкольный возраст имеет исключительно важное значение в жизни человека. В этот период закладывается фундамент здоровья, начинают развиваться разнообразные способности, формируются нравственные качества, складываются черты характера. От того как воспитывается ребенок в эти годы, во многом зависит его будущее, эффективность школьного обучения, последующее формирование личност

The embryonic node behaves as an instructive stem cell niche for axial elongation

In warm-blooded vertebrate embryos (mammals and birds), the axial tissues of the body form from a growth zone at the tail end, Hensen’s node, which generates neural, mesodermal, and endodermal structures along the midline. While most cells only pass through this region, the node has been suggested to contain a small population of resident stem cells. However, it is unknown whether the rest of the node constitutes an instructive niche that specifies this self-renewal behavior. Here, we use heterotopic transplantation of groups and single cells and show that cells not destined to enter the node can become resident and self-renew. Long-term resident cells are restricted to the posterior part of the node and single-cell RNA-sequencing reveals that the majority of these resident cells preferentially express G2/M phase cell-cycle–related genes. These results provide strong evidence that the node functions as a niche to maintain self-renewal of axial progenitors

Характеристика биохимического состава и антиоксидантной активности Spinacia oleracea L. и Spinacia turkestanica Iljin.: сравнительное исследование

Spinach is an economically important vegetable crop widely cultivated and consumed worldwide. This early ripening leafy vegetable is rich in bioactive components, fiber, micro and macro elements, vitamins, and has high antioxidant activity. Results of numerous studies on the effects of spinach on human health confirm its beneficial effect. The species S. oleracea L. is cultivated commercially. The ancestor of cultivated spinach is S. turkestanica Iljin, which has a breeding potential for different economically valuable traits. Its biochemical composition has been studied extremely little. The present article offers a comparative evaluation of the biochemical profile and antioxidant activity of cultivated and wild spinach species. The material for the study was a representative sample of 48 collection accessions of spinach from the N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR). The accessions were grown in 2019 and 2020 in the open ground of the Pushkin and Pavlovsk Laboratories of VIR. The antioxidant activity was studied spectrophotometrically by the DPPH assay of free radical scavenging at a wavelength of 515 nm. A significant similarity of the two species in most biochemical parameters was revealed, which confirms their phylogenetic relationship. Significant differences were found in the content of phenolic elements, which determine the elevated values of antioxidant and antiradical activity of S. turkestanica. The article presents correlation matrices of species biochemical composition, describes general trends, negative relationships and conjugated factors. The identified promising accessions of both cultivated and wild spinach are recommended for breeding for increased content of phenolic compounds, ascorbic acid and antioxidant activity. The result of the study helps to reveal the potential of the crop as a valuable source of bioactive components and high antioxidant activity.Шпинат - экономически значимая овощная культура, широко возделываемая и потребляемая во всем мире. Этот скороспелый листовой овощ богат биологически активными компонентами, клетчаткой, микро- и макроэлементами, витаминами, обладает высокой антиоксидантной активностью. Многочисленные результаты изучения влияния шпината на здоровье человека подтверждают его благотворное действие. В производстве культивируют вид S. oleracea L. Прародителем культурного вида шпината является вид S. turkestanica Iljin., обладающий потенциалом для селекции по различным хозяйственно-ценным признакам. Его биохимический состав изучен крайне мало. В настоящей работе дана сравнительная оценка биохимического профиля и антиоксидантной активности культурного и дикого видов шпината. Материалом для исследования послужила репрезентативная выборка из 48 образцов коллекции шпината ВИР. Образцы выращивались в 2019 и 2020 году в условиях открытого грунта Пушкинских и Павловских лабораторий Всероссийского института генетических ресурсов растений имени Н.И. Вавилова. Антиоксидантную активность изучали методом DPPH на спектрофотометре путем поглощения свободных радикалов раствора, измеряемое при длине волны 515 нм. Выявлено значительное сходство двух видов по большинству биохимических показателей, что подтверждает их филогенетическое родство. Существенные различия обнаружены в содержании фенольных элементов, определяющих повышенные значения антиоксидантной и антирадикальной активности S. turkestanica Iljin. В статье приведены корреляционные матрицы видового биохимического состава, описаны общие тенденции, отрицательные взаимосвязи и сопряженные факторы. Выделившиеся перспективные образцы как культурного, так и дикого видов шпината рекомендованы для селекции на увеличение содержания фенольных соединений, аскорбиновой кислоты и антиоксидантной активности. Результат исследования помогает раскрыть потенциал культуры, как ценного источника биологически-активных компонентов и высокой антиоксидантной активности

Privatization by the people - who will take advantage?

Developing a crisis management plan for the current year, the Government solves the problem of closing the Federal budget deficit in 2016. Options for finding sources of funds may be several. The government intends to close the deficit partially by selling significant stakes in leading companies belonging to the state. Leading economists of the expert community does not consider the decision of the government and technology for the implementation of this project optimal for the Russian economy and social state of society.Разрабатывая антикризисный план на текущий год, Правительство РФ решает проблему закрытия дефицита федерального бюджета 2016 года. Вариантов нахождения источников средств может быть несколько. Правительство намерено закрыть дефицит, частично продав значительные пакеты акций ведущих предприятий, принадлежащие государству. Ведущие экономисты экспертного сообщества не считают решение правительства и технологию осуществления данного проекта оптимальными для российской экономики и социального состояния общества

The effect of the August 21, 2017 total solar eclipse on the phase of VLF/LF signals

An experimental study of the phase and amplitude observations of sub‐ionospheric very low and low frequency signals is performed to analyse the response of the lower ionosphere during the August 21, 2017 total solar eclipse in the United States of America. Three different sub‐ionospheric wave paths are investigated. The length of the paths varies from 2200 to 6400 km and the signal frequencies are 21.4 kHz, 25.2 kHz and 40.75 kHz. The two paths cross the region of the total eclipse and the third path is in the region of 40‐60% of obscuration. None of the signals reveal any noticeable amplitude changes during the eclipse while negative phase anomalies (from ‐33° to ‐95°) are detected for all three paths. It is shown that the effective reflection height of the ionosphere in low and middle latitudes is increased by about 3‐5 km during the eclipse. Estimation of the electron density change in the lower ionosphere caused by the eclipse, using linear recombination law, shows that the average decrease is by 2.1 to 4.5 times

Efficiency and safety of various dual antiplatelet therapy strategies in patients undergoing percutaneous coronary intervention due to myocardial infarction

Aim. To compare the efficacy and safety of prasugrel, ticagrelor, or clopidogrel as part of dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention (PCI) due to myocardial infarction (MI).Material and methods. The observational study included 74 patients who underwent PCI due to MI within the first 24 hours after the onset. The patients were devided into 3 groups: group 1 — patients who received ticagrelor as part of DAPT; group 2 — clopidogrel, group 3 — prasugrel. The follow-up period was 28 days. To assess the efficacy and safety of therapy, a composite endpoint was assessed (death + nonfatal recurrent MI (and/or stent rethrombosis) + nonfatal ischemic stroke (IS). Additional secondary endpoints were any moderate and severe (major) bleeding according to the GUSTO and/or TIMI scales. We assessed the incidence of reperfusion arrhythmias, an opening of an infarct-related coronary artery (IRCA), and non-ST elevation myocardial infarction (non-STEMI).Results. The analysis showed no significant differences in the cumulative incidence of adverse outcomes in the study groups within 28 days. The prevalence of secondary endpoints over a 28-day follow-up period was 3,1% in the ticagrelor group and 5,9% in the clopidogrel group, while no moderate and life-threatening bleeding was recorded in the prasugrel group during. There were no significant differences in the incidence of reperfusion arrhythmias, opening of an IRCA, and non-STEMI between the groups.Conclusion. The obtained results suggest the comparable efficacy and safety profiles of prasugrel, ticagrelor and clopidogrel as a part of DAPT in patients undergoing PCI due to MI. There were no significant differences in endpoint event rates. In particular, prasugrel has been shown to be as effective and safe as ticagrelor

Effectiveness of mindfulness-based therapy, stress reduction in hypertension and prehypertension: a systematic review

Aim. To collect and analyze currently available clinical studies on the effectiveness of mindfulness-based stress reduction (MBSR) for lowering blood pressure in individuals with normal, high normal blood pressure and hypertension.Material and methods. The systematic review was prepared according to the PRISMA algorithm with minor modifications. The search algorithm included articles in Russian and English, indexed in the Pubmed/MEDLINE and Cochrane Library databases. The study included studies on the impact of mindfulness interventions on blood pressure levels in individuals aged ≥18 years with an established diagnosis of hypertension, with normal (120-129/80-84 mm Hg) and high normal office blood pressure (130-139/85-89 mm Hg).Results. A total of 4785 publications were identified and included in the study, of which, after a multistage sampling, including screening of articles, 6 studies were included in a qualitative systematic review.Conclusion. Qualitative synthesis of the results of clinical studies revealed that the evidence currently available indicates a possible positive effect of mindfulness interventions on blood pressure levels in individuals with normal, high normal blood pressure and hypertension. However, further studies with larger samples and measurement of more primary and secondary endpoints are required

Mobile applications for anxiety and stress reduction: potential for preventing noncommunicable diseases

The article discusses using mobile applications for smartphones as tools to reduce anxiety and stress. The modern views on pathogenesis of the relationship between stress, anxiety disorders and cardiovascular disease are considered. Based on a review of some representative studies, a methodology for evaluating the characteristics and functions of mobile applications for managing anxiety and stress symptoms is proposed. The applications selected for analysis were tested according to this methodology. There are following key features of the Russianlanguage field of mobile applications for anxiety and stress reduction: a small number of applications, high prevalence of using breathing exercises, meditations and sound therapy, an extremely low disease specificity and focus mainly on helping with general symptoms of anxiety

Main Directions of Environmental Policy of Greenland at Beginning of XXI Century

The individual directions of Greenland’s environmental policy, which have the greatest impact on the modern ecological situation in the autonomy, are considered. The authors of the work referred to these areas as energy, water resources, waste disposal and pollution control. A description of the development of the selected ecological directions is given, an analysis of their current state is carried out. Greenland’s environmental cooperation with Denmark and the European Union is also analyzed. The basis of the source study base of the article is the Greenlandic legislation in the field of ecology. The main documents, programs and cases that influenced the development of the selected environmental directions are considered. The relevance of this article lies in a detailed examination of the environmental policy of Greenland and the construction of general conclusions about the environmental situation of the Danish Autonomous Territory based on the results obtained in the analysis of individual environmental areas. The novelty of the study is seen in an integrated approach to the analysis of the ongoing environmental policy of Greenland. The main positive and negative results in the selected environmental areas are noted. An assumption is made about the ambiguity of the environmental policy of Greenland, and possible outcomes in the implementation of this policy are considered