Digital Transformation of Russia’s Agricultural Sector

The paper presents a methodical approach to the assessment of agricultural sector transformation in the conditions of intensive penetration of digital technologies into the economy sector. The authors offer a schematic diagram of data collecting and processing in the start-to-finish automated production-and-marketing chain of activity within the agricultural secto

Estado psicoemocional dos alunos durante o período de autoisolamento pandêmico da COVID-19 no contexto dos fatores sociodemográficos

Psycho-emotional state of youth in the COVID-19 pandemic can become an indicator of various positive or negative social transformations and trends. The purpose of the study is to determine the influence of socio-demographic factors (gender, age, year of study, the direction of professional training at university, combining study and work, living in a rural area or a city, in a private house or an apartment, with parents or independently) in conditions of self-isolation on assessment of the main components of the psycho-emotional state of the students: well-being, activity, and mood. We used the method of rapid well-being, activity, and mood assessment. The test was conducted online; the relevant materials were posted on eCampus of North Caucasus Federal University educational portal. The research results analysis was based on Kruskal Wallice H-test, the primary frequency analysis, analysis of average scale values and standard deviations for the comparison groups. The study was conducted from April 13 to May 22, 2020, and involved 1,173 students aged 17 to 36 years, enrolled in 1-5 years. The study suggests that the psycho-emotional state of students in the self-isolation period depends on their age: the younger the students are, the more likely they are to experience fatigue and decline in well-being, activity, mood. The study provided new data on the features of integrated assessments of students’ well-being, activity, and mood in conditions of forced self-isolation due to the COVID-19 pandemic.El estado psicoemocional de los jóvenes en la pandemia de COVID-19 puede convertirse en un indicador de diversas transformaciones y tendencias sociales positivas o negativas. El propósito del estudio es determinar la influencia de factores sociodemográficos (género, edad, año de estudio, dirección de la formación profesional en la universidad, compaginación de estudio y trabajo, vivir en una zona rural o en una ciudad, en una casa particular). o un apartamento, con los padres o de forma independiente) en condiciones de autoaislamiento al evaluar los principales componentes del estado psicoemocional de los estudiantes: bienestar, actividad y estado de ánimo. Usamos el método de evaluación rápida del bienestar, la actividad y el estado de ánimo. La prueba se realizó en línea; los materiales pertinentes se publicaron en el portal educativo eCampus of North Caucasus Federal University. El análisis de los resultados de la investigación se basó en la prueba H de Kruskal Wallice, el análisis de frecuencia principal, el análisis de los valores de escala promedio y las desviaciones estándar para los grupos de comparación. El estudio se realizó del 13 de abril al 22 de mayo de 2020 e involucró a 1,173 estudiantes de 17 a 36 años, matriculados en 1-5 años. El estudio sugiere que el estado psicoemocional de los estudiantes en el período de autoaislamiento depende de su edad: cuanto más jóvenes son los estudiantes, es más probable que experimenten fatiga y deterioro del bienestar, la actividad y el estado de ánimo. El estudio proporcionó nuevos datos sobre las características de las evaluaciones integradas del bienestar, la actividad y el estado de ánimo de los estudiantes en condiciones de autoaislamiento forzado debido a la pandemia COVID-19.O estado psicoemocional dos jovens na pandemia COVID-19 pode se tornar um indicador de várias transformações e tendências sociais positivas ou negativas. O objetivo do estudo é verificar a influência de fatores sociodemográficos (sexo, idade, ano de estudo, direção da formação profissional na universidade, conciliar estudo e trabalho, residir em área rural ou na cidade, em residência particular ou um apartamento, com os pais ou independentemente) em condições de auto-isolamento na avaliação dos principais componentes do estado psicoemocional dos alunos: bem-estar, atividade e humor. Usamos o método de avaliação rápida de bem-estar, atividade e humor. O teste foi realizado online; os materiais relevantes foram postados no portal educacional eCampus da Universidade Federal do Norte do Cáucaso. A análise dos resultados da pesquisa foi baseada no teste H de Kruskal Wallice, análise de frequência primária, análise dos valores médios da escala e desvios-padrão para os grupos de comparação. O estudo foi realizado de 13 de abril a 22 de maio de 2020, e envolveu 1.173 alunos com idades entre 17 e 36 anos, matriculados em 1-5 anos. O estudo sugere que o estado psicoemocional dos alunos no período de auto-isolamento depende da idade: quanto mais jovens são os alunos, maior é a probabilidade de sofrerem de fadiga e declínio no bem-estar, atividade, humor. O estudo forneceu novos dados sobre as características das avaliações integradas do bem-estar, atividade e humor dos alunos em condições de auto-isolamento forçado devido à pandemia COVID-19.

Frequency of hemodynamic response to orthostatic stress in heart failure with reduced ejection fraction, associations with clinical blood pressure

Aim. To assess hemodynamic response to active standing test (AST) with beat-to-beat blood pressure (BP) monitoring, their association with office BP and symptoms of orthostatic intolerance in patients with heart failure (HF).Material and methods. Outpatient HF patients with documented  left ventricular ejection  fraction <40%, followed   up in a HF center  and receiving optimal medical therapy, underwent AST with beat-to-beat  non-invasive BP monitoring.Hemodynamic response was assessed according to the European Federation of Autonomic Societies criteria.Results. The study included 87 patients (mean age, 57±10 years; men, 76%). Normal hemodynamic response to orthostatic stress was observed  in 36 (41,4%) patients. Pathological response prevailed during the first minute of orthostatic stress — initial orthostatic hypotension (OH) (n=29, 33,3%) and delayed BP recovery (n=18, 20,7%).  Classical OH was detected  in 4 (4,6%)  patients. There was no orthostatic hypertension, defined as an increase in systolic BP (SBP) ≥20 mm Hg. According to office BP, hypotension was observed in 19 (21,8%) patients (SBP <90 mm Hg in 4 patients and 90-100 mm Hg in 15), hypertension (SBP >140 mm Hg) in 11 (12,6%) patients. Pathological response to orthostatic stress were more often observed  in office  SBP >140 mm Hg compared  to SBP ≤140 mmHg (90,9% and 53,9%, p=0,020).Orthostatic intolerance was noted in 43 (49,4%) patients and were not associated with the level of office SBP (p=0,398) or pathological responses to orthostatic stress (p=0,758 for initial OH and p=0,248  for delayed  BP recovery).Conclusion. The pathological hemodynamic response in AST with beat-to-beat BP monitoring in ambulatory patients with HF is most often represented  by initial OH and delayed BP recovery associated  with office SBP >140 mmHg. The frequency of symptoms of orthostatic intolerance did not differ between groups depending on the presence of an inadequate response to orthostatic stress

Способ бескоксовой переработки ванадийсодержащего рудного сырья с получением легированной ванадием стали, горячих металлизованных окатышей и ванадиевого шлака

Изобретение относится к области металлургии, в частности к процессам металлизации и электросталеплавильному производству. В шахтной печи осуществляют металлизацию ванадийсодержащего рудного сырья с использованием в качестве восстановителя горячих восстановительных газов, поступающих из газификатора с жидкой ванной, где с одновременным получением газа производятся ванадийсодержащий полупродукт и ванадийсодержащий шлак. Металлизованное сырье, ванадийсодержащий полупродукт, металлургический скрап подают в дуговую электропечь для выплавки стали. Перед подачей в электропечь ванадийсодержащий полупродукт поступает в агрегат деванадации для окисления ванадия с получением рафинированного полупродукта и ванадийсодержащего шлака. После чего рафинированный полупродукт, металлизованное сырье и металлургический скрап подают в электропечь. В электропечи вначале проплавляют рафинированный полупродукт и металлургический скрап, сливают шлак и на полученный расплав подают и проплавляют металлизованное сырье до получения стали. Ванадийсодержащий шлак, полученный при деванадации ванадийсодержащего полупродукта, а также не использованное для выплавки стали металлизованное сырье, полученное в шахтной печи, используют как товарную продукцию. Преимуществом предлагаемого изобретения является удешевление процесса получения легированной ванадием стали, снижение энергоемкости процесса и увеличение степени извлечения ванадия на всех стадиях технологической цепочки

Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period

BIOAVAILABILITY OF CURCUMIN AND METHODS OF ITS ENHANCING

Curcumin is a hydrophobic polyphenolic compound of natural origin. Curcumin has a wide range of pharmacological effects. Curcumin is inherently poorly absorbed when ingested and has low bioavailability, in part due to a low rate of absorption in the intestine and, in part, due to rapid metabolism (glucuronidation), which limits its clinical use. One of the important tasks is the development of effective forms of curcumin with the aim of increasing the bioavailability of this compound. This is achieved by including curcumin in such systems as liposomes, nanoparticles, micelles, etc., formation of complexes with cyclodextrins, and the use of bio-enhancers. In particular, the use of a complex of curcumin with piperine, a known inhibitor of the glucuronization process in the liver and intestine, increased the bioavailability of curcumin several times. Combination of curcumin with phospholipids due to its incorporation into lipophilic membranes, increased its maximum concentration in comparison with an individual curcumin. Curcumin in the form of nanoparticles had a pharmacological effect at a 15-fold lower concentration than conventional curcumin

Photobiomodulation for Correction of Systemic Disorders of Experimental Pain Syndromes

The development of anti-pain technologies in the complex treatment of pain syndromes is one of the most urgent tasks of modern medicine. We undertook a placebo-controlled experimental study of the therapeutic potential of low-intensity laser radiation when applied to acupuncture points that are directly related to the autonomic nervous system. The adaptation effect of puncture photobiomodulation on the induction of stress-mediated autonomic reactions, oxidative metabolism and microcirculation in animals during the acute phase of pain stress was revealed. The data obtained are of interest for use in the complex rehabilitation of patients with pain syndromes

The Relevance of Vaccination against Pneumococcal Disease to the Child Population of Krasnoyarsk

The paper presents evidence of the relevance of pneumococcal infection (PI) in children of Krasnoyarsk. The most severe form of PI is pneumococcal meningitis that characterizes by lesion of not only meninges but brain substance, extreme severity, long-term nonsmooth flow with the development of complications that threaten a patient's life. The inclusion of pneumococcal conjugate vaccine in the planned childhood immunization scheme will significantly reduce the severity of these diseases

Prolonged reception of cholecalcipherol – the basis of effective prevention of hypovitaminosis D in young years

Introduction. Vitamin D plays a fundamental role in the regulation of calcium and phosphorus homeostasis, and in recent decades its non-calcemic effects have been intensively studied.The aim of the work was to analyze the patterns of vitamin D availability in young children against the background of prolonged use of an aqueous solution of cholecalciferol in preventive doses.Materials and methods: 192 children of the first three years of life were examined (Arkhangelsk – 77 (40.1%), Moscow – 38 (19.8%), Stavropol – 77 (40.1%) children). Assessment of vitamin D availability was carried out by the level of serum calcidiol (25(OH)D). Based on the initial vitamin D supply, patients were divided into groups, and participants used cholecalciferol preparations for 30 days.Results. The baseline vitamin D supply was 26.0 (19.5–35.4) ng/ml. Median 25(OH)D in children in the Moscow region is higher than in Arkhangelsk and Stavropol (p<0.0001). After using vitamin D in therapeutic doses, the median 25 (OH) D in Arkhangelsk was 46.7 (32.3–64.5) ng/ml, in Moscow – 52.6 (40.2–64.9) ng/ml, in Stavropol – 51.4 (41.3–69.8) ng/ml. According to the results of taking the prophylactic dose (1000 IU/day), satisfactory vitamin D was detected in 105 (54.7%) patients, insufficiency (from 20 to 30 ng/ml) – in 70 (36.5%), deficiency (from 10 up to 20 ng/ml) – in 17 (8.8%) children. Among children who had a 25(OH)D level of more than 30 ng/ml at the end of the study, the use of vitamin D preparations of 50–100 IU/kg and in 42 (41.0%) was effective in 62 (59.0%) children – in a dose of 100–150 IU/day, and in the group of patients with a level of 25(OH)D less than 30 ng/ml – a dose of 50 to 100 IU/kg was used in 69 (79.3%) patients, and a dosage of 100–150 IU/kg in only 18 (20.7%) children (p < 0.0005).Conclusion. The used prophylactic dosage of 1000 IU/day of an aqueous solution of cholecalciferol was effective in most compliance children. The elimination of deficiency and the prevention of vitamin D deficiency is most effective when used for 6 months or more