The systemic inflammatory response to exercise in adults with cystic fibrosis

AbstractExercise is associated with release of inflammatory mediators in the circulation and there is evidence that the exercising muscles and tendons are sources of interleukin-6. Due to the catabolic effects of some cytokines, increased release in circulation might contribute to alterations in body composition in adults with cystic fibrosis. We hypothesised that exercise of moderate intensity would generate increased blood concentrations of some inflammatory mediators.We investigated the change in blood concentrations of interleukin-6, tumour necrosis factor alpha and their soluble receptors after a structured exercise (box stepping) of intensity similar to that encountered during activities of daily living in 12 adults with cystic fibrosis and mean (95% confidence interval) FEV1 55.6 (44.4, 66.8)% predicted, body mass index 23.0 (21.3, 24.6) kg/m2 and 12 healthy subjects.The increments post-exercise for all inflammatory mediators and lactate corrected for the work performed until voluntary exhaustion were greater for patients, while the total work was less for patients (all p<0.01). Daytime variability of the inflammatory mediators was assessed in eight patients and was less than the change due to exercise.We report greater increments in circulating concentrations of some cytokines with moderate exercise in adults with cystic fibrosis compared to healthy subjects

第787回千葉医学会例会・第4回磯野外科例会 84.

Misplaced SNPs. It presents all cases of misplaced SNPs found in this study (PDF 3034 kb

Additional file 4: Table S3. of Identifying highly informative genetic markers for quantification of ancestry proportions in crossbred sheep populations: implications for choosing optimum levels of admixture

Least square means ± standard errors of lamb eight months weight for crossbred population by location, different Awassi level groups and sex in Negasi-Amba and Chiro villages. (DOC 48 kb

Additional file 7: Figure S6. of Revealing misassembled segments in the bovine reference genome by high resolution linkage disequilibrium scan

Partially Misassembled Contig (PmisCon). It presents all cases of partially misassembled contigs of the reference genome found in this study (PDF 7832 kb

Additional file 4: Table S1. of Revealing misassembled segments in the bovine reference genome by high resolution linkage disequilibrium scan

Full description of signatures of misassemblies and their estimated true location (XLSX 35 kb