Large-scale compartment fires to develop a self-extinction design framework for mass timber—Part 1: Literature review and methodology

Fire safety remains a major challenge for engineered timber buildings. Their combustible nature challenges the design principles of compartmentation and structural integrity beyond burnout, which are inherent to the fire resistance framework. Therefore, self-extinction is critical for the fire-safe design of timber buildings. This paper is the first of a three-part series that seeks to establish the fundamental principles underpinning a design framework for self-extinction of engineered timber. The paper comprises: a literature review introducing the body of work developed at material and compartment scales; and the design of a large-scale testing methodology which isolates the fundamental phenomena to enable the development and validation of the required design framework. Research at the material scale has consolidated engineering principles to quantify self-extinction using external heat flux as a surrogate of the critical mass loss rate, and mass transfer or Damköhler numbers. At the compartment scale, further interdependent, complex phenomena influencing self-extinction occurrence have been demonstrated. Time-dependent phenomena include encapsulation failure, fall-off of charred lamellae and the burning of the movable fuel load, while thermal feedback is time-independent. The design of the testing methodology is described in reference to these fundamental phenomena

Association between T2-related co-morbidities and effectiveness of biologics in severe asthma

Acknowledgments The authors thank Mr. Joash Tan (BSc, Hons), of the Observational and Pragmatic Research Institute (OPRI), and Ms Andrea Lim (BSc, Hons) of the Observational Pragmatic Research Institute (OPRI) for their editorial and formatting assistance that supported the development of this publication. Funding statement: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global and AstraZeneca Ltd. AstraZeneca UK LimitedPeer reviewe

Malaria vector species in Colombia: a review

Here we present a comprehensive review of the literature on the vectorial importance of the major Anopheles malaria vectors in Colombia. We provide basic information on the geographical distribution, altitudinal range, immature habitats, adult behaviour, feeding preferences and anthropophily, endophily and infectivity rates. We additionally review information on the life cycle, longevity and population fluctuation of Colombian Anopheles species. Emphasis was placed on the primary vectors that have been epidemiologically incriminated in malaria transmission: Anopheles darlingi, Anopheles albimanus and Anopheles nuneztovari. The role of a selection of local, regional or secondary vectors (e.g., Anopheles pseudopunctipennis and Anopheles neivai) is also discussed. We highlight the importance of combining biological, morphological and molecular data for the correct taxonomical determination of a given species, particularly for members of the species complexes. We likewise emphasise the importance of studying the bionomics of primary and secondary vectors along with an examination of the local conditions affecting the transmission of malaria. The presence and spread of the major vectors and the emergence of secondary species capable of transmitting human Plasmodia are of great interest. When selecting control measures, the anopheline diversity in the region must be considered. Variation in macroclimate conditions over a species' geographical range must be well understood and targeted to plan effective control measures based on the population dynamics of the local Anopheles species

Platform for Plasmodium vivax vaccine discovery and development

Plasmodium vivax is the most prevalent malaria parasite on the American continent. It generates a global burden of 80-100 million cases annually and represents a tremendous public health problem, particularly in the American and Asian continents. A malaria vaccine would be considered the most cost-effective measure against this vector-borne disease and it would contribute to a reduction in malaria cases and to eventual eradication. Although significant progress has been achieved in the search for Plasmodium falciparum antigens that could be used in a vaccine, limited progress has been made in the search for P. vivax components that might be eligible for vaccine development. This is primarily due to the lack of in vitro cultures to serve as an antigen source and to inadequate funding. While the most advanced P. falciparum vaccine candidate is currently being tested in Phase III trials in Africa, the most advanced P. vivax candidates have only advanced to Phase I trials. Herein, we describe the overall strategy and progress in P. vivax vaccine research, from antigen discovery to preclinical and clinical development and we discuss the regional potential of Latin America to develop a comprehensive platform for vaccine development

Identificación de factores de riesgo y riesgo asociados al proceso de corte de acero en industria metal mecánica en Santiago de Cali – valle del cauca en el año 2013

La presente compilación surge de la necesidad de identificar los factores de riesgo y riesgo asociados al proceso de corte de acero en industrias metal mecánica en Santiago de Cali – Valle del Cauca - Colombia en el año 2013 herramienta (compilación) que permite recolectar información de los factores de riesgo y riesgo asociados a los que está expuesto el trabajador en el desempeño de su actividad y que puede impactar en las condiciones de salud del mismo. La identificación de factores de riesgo y riesgo asociados debe dar cuenta en lo posible cual es la fuente que genera dicho riesgo para su correspondiente control. Se presenta la descripción teórica del proceso en metal mecánica identificando los factores de riesgo y riesgo asociados en el proceso de corte de acero. Luego se presenta las medidas de control identificando el proceso, factor de riesgo, riesgo, fuente y por ende medidas de control.1.Justificación2.Planteamiento del problema3.Objetivos4.Marco de referencia5. Metodología6.Desarrollo del tema7.Recomendaciones8.ConclusionesPregradoProfesional en Seguridad y Salud en el Trabaj

Factors Affecting the Time and Process of CMC Drying Using Refractance Window or Conductive Hydro-Drying

Intensive research on biodegradable films based on natural raw materials such as carboxymethyl cellulose (CMC) has been performed because it enables the production of transparent films with suitable barrier properties against oxygen and fats. Considering the importance of the production of this type of film at the industrial level, a scalable and continuous drying method is required. Refractance window-conductive hydro drying (RW-CHD) is a sustainable and energy-efficient method with high potential in drying this kind of compound. The objective of this study was to evaluate the factors (CMC thickness, heating water temperature, and film type) and radiation penetration depth that affect drying time and energy consumption. It was found that drying time decreased with increasing temperature and decreasing thickness. Similarly, energy consumption decreased with decreasing temperature and thickness. However, the drying time and energy consumed per unit weight of product obtained were equivalent when drying at any of the thicknesses evaluated. Film type had little effect on time and energy consumption compared to the effects of temperature and CMC thickness. The radiation penetration depth into the CMC was determined to be 1.20 ± 0.19 mm. When the thickness was close to this value, the radiation energy was better utilized, which was reflected in a higher heating rate at the beginning of drying