The Role of Bordetella Infections in Patients with Acute Exacerbation of Chronic Bronchitis

Abstract : Background: : Acute exacerbations of chronic bronchitis (AECB) are associated with a variety of viral and bacterial infectious agents, some of which are potentially preventable by immunization. Bordetella pertussis, which causes whooping cough, has not been studied in this context. We aimed to assess the role of Bordetella infections in patients with AECB. Patients and Methods: : Patients with AECB, who presented to participating private practices in Basel, Switzerland, between October 2000 and June 2002, were evaluated by a standardized questionnaire, nasopharyngeal swabs for culture (Bordetella spp.), and PCR (Bordetella spp. and selected other respiratory pathogens) and paired blood samples for serologic diagnosis of Bordetella infection. Results: : A total of 26 patients (34-86 years of age) were recruited. All culture and PCR samples were negative. Serology revealed Bordetella infection in eight (31%) patients. Duration of cough was shorter in patients with Bordetella infection compared to those without Bordetella infection (mean 15 days vs 41 days, p = 0.04). Cough ≥ 21 days duration was present in three (43%) of seven patients with evidence of Bordetella infection compared to 17 (94%) of 18 controls (p = 0.012). Progression to convalescence from initial to follow-up visit after 4-6 weeks was comparable between both groups. Conclusion: : Bordetella infections appear to play a significant role in AECB and preventive measurements such as immunization with acellular pertussis vaccines should be considered. Extended investigations are necessary to confirm our preliminary and provocative finding

Regression of AIDS-Related Kaposi's Sarcoma During Therapy with Thalidomide

A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of granulocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in bloo

An Intrisic Topology for Orthomodular Lattices

We present a general way to define a topology on orthomodular lattices. We show that in the case of a Hilbert lattice, this topology is equivalent to that induced by the metrics of the corresponding Hilbert space. Moreover, we show that in the case of a boolean algebra, the obtained topology is the discrete one. Thus, our construction provides a general tool for studying orthomodular lattices but also a way to distinguish classical and quantum logics.Comment: Under submission to the International Journal of Theoretical Physic

Multiple query optimization using a gate-based quantum computer

Quantum computing promises to solve difficult optimization problems in chemistry, physics and mathematics more efficiently than classical computers. However, it requires fault-tolerant quantum computers with millions of qubits; a technological challenge still not mastered by engineers. To lower the barrier, hybrid algorithms combining classical and quantum computers are used, where quantum computing is only used for those parts of computation that cannot be solved efficiently otherwise. In this paper, we tackle the multiple query optimization problem (MQO), an important NP-hard problem in database research. We present an implementation based on a scheme called quantum approximate optimization algorithm to solve the MQO on a gate-based quantum computer. We perform a detailed experimental evaluation of our implementation and compare its performance against a competing approach that employs a quantum annealer – another type of quantum computer. Our implementation shows a qubit efficiency of close to 99%, which is almost a factor of 2 higher than the state-of-the-art implementation. We emphasize that the problems we can solve with current gate-based quantum technology are fairly small and might not seem practical yet compared to state-of-the-art classical query optimizers. However, our experiments on using a hybrid approach of classical and quantum computing show that our implementation scales favourably with larger problem sizes. Hence, we conclude that our approach shows promising results for near-term quantum computers and thus sets the stage for a challenging avenue of novel database research

Hilbert Lattice Equations

There are five known classes of lattice equations that hold in every infinite dimensional Hilbert space underlying quantum systems: generalised orthoarguesian, Mayet's E_A, Godowski, Mayet-Godowski, and Mayet's E equations. We obtain a result which opens a possibility that the first two classes coincide. We devise new algorithms to generate Mayet-Godowski equations that allow us to prove that the fourth class properly includes the third. An open problem related to the last class is answered. Finally, we show some new results on the Godowski lattices characterising the third class of equations.Comment: 24 pages, 3 figure

Division Algebras and Quantum Theory

Quantum theory may be formulated using Hilbert spaces over any of the three associative normed division algebras: the real numbers, the complex numbers and the quaternions. Indeed, these three choices appear naturally in a number of axiomatic approaches. However, there are internal problems with real or quaternionic quantum theory. Here we argue that these problems can be resolved if we treat real, complex and quaternionic quantum theory as part of a unified structure. Dyson called this structure the "three-fold way". It is perhaps easiest to see it in the study of irreducible unitary representations of groups on complex Hilbert spaces. These representations come in three kinds: those that are not isomorphic to their own dual (the truly "complex" representations), those that are self-dual thanks to a symmetric bilinear pairing (which are "real", in that they are the complexifications of representations on real Hilbert spaces), and those that are self-dual thanks to an antisymmetric bilinear pairing (which are "quaternionic", in that they are the underlying complex representations of representations on quaternionic Hilbert spaces). This three-fold classification sheds light on the physics of time reversal symmetry, and it already plays an important role in particle physics. More generally, Hilbert spaces of any one of the three kinds - real, complex and quaternionic - can be seen as Hilbert spaces of the other kinds, equipped with extra structure.Comment: 30 pages, 3 encapsulated Postscript figure