Photoproduction of mesons off nuclei

Recent results for the photoproduction of mesons off nuclei are reviewed. These experiments have been performed for two major lines of research related to the properties of the strong interaction. The investigation of nucleon resonances requires light nuclei as targets for the extraction of the isospin composition of the electromagnetic excitations. This is done with quasi-free meson photoproduction off the bound neutron and supplemented with the measurement of coherent photoproduction reactions, serving as spin and/or isospin filters. Furthermore, photoproduction from light and heavy nuclei is a very efficient tool for the study of the interactions of mesons with nuclear matter and the in-medium properties of hadrons. Experiments are currently rapidly developing due to the combination of high quality tagged (and polarized) photon beams with state-of-the-art 4pi detectors and polarized targets

Dependence of calculated binding energies and widths of η\eta-mesic nuclei on treatment of subthreshold η\eta-nucleon interaction

We demonstrate that the binding energies and widths of eta-mesic nuclei depend strongly on subthreshold eta-N interaction. This strong dependence is made evident from comparing three different eta-nucleus optical potentials: (1) a microscopic optical potential taking into account the full effects of off-shell eta-nucleon interactions; (2) a factorization approximation to the microscopic optical potential where a downward energy shift parameter is introduced to approximate the subthreshold eta-nucleon interaction; and (3) an optical potential using on-shell eta-nucleon scattering length as the interaction input. Our analysis indicates that the in-medium $\eta$N interaction for bound-state formation is about 30 MeV below the free-space $\eta$N threshold, which causes a substantial reduction of the attractive force between the $\eta$ and nucleon with respect to that implied by the scattering length. Consequently, the scattering-length approach overpredicts the binding energies and caution must be exercised when these latter predictions are used as guide in searching for $\eta$-nucleus bound states. We also show that final-state-interaction analysis cannot provide an unequivocal determination of the existence of $\eta$-nucleus bound state. More direct measurements are, therefore, necessary.Comment: 28 pages, 1 figur

Creation of the precision magnetic spectrometer SCAN-3

The new JINR project [1] is aimed at studies of highly excited nuclear matter created in nuclei by a high-energy deuteron beam. The matter is studied through observation of its particular decay products - pairs of energetic particles with a wide opening angle, close to 180°. The new precision hybrid magnetic spectrometer SCAN-3 is to be built for detecting charged (π±, K±, p) and neutral (n) particles produced at the JINR Nuclotron internal target in dA collisions. One of the main and complex tasks is a study of low-energy ηA interaction and a search for η-bound states (η-mesic nuclei). Basic elements of the spectrometer and its characteristics are discussed in the article

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discoveries has been challenging. Here, to complement GWASs and better define actionable biological targets, we analyzed sequence data from more than 30,000 patients with CD and 80,000 population controls. We directly implicate ten genes in general onset CD for the first time to our knowledge via association to coding variation, four of which lie within established CD GWAS loci. In nine instances, a single coding variant is significantly associated, and in the tenth, ATG4C, we see additionally a significantly increased burden of very rare coding variants in CD cases. In addition to reiterating the central role of innate and adaptive immune cells as well as autophagy in CD pathogenesis, these newly associated genes highlight the emerging role of mesenchymal cells in the development and maintenance of intestinal inflammation.Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn's disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.Cellular mechanisms in basic and clinical gastroenterology and hepatolog