Rapid prototyping for biomedical engineering: current capabilities and Challenges

A new set of manufacturing technologies has emerged in the past decades to address market requirements in a customized way and to provide support for research tasks that require prototypes. These new techniques and technologies are usually referred to as rapid prototyping and manufacturing technologies, and they allow prototypes to be produced in a wide range of materials with remarkable precision in a couple of hours. Although they have been rapidly incorporated into product development methodologies, they are still under development, and their applications in bioengineering are continuously evolving. Rapid prototyping and manufacturing technologies can be of assistance in every stage of the development process of novel biodevices, to address various problems that can arise in the devices' interactions with biological systems and the fact that the design decisions must be tested carefully. This review focuses on the main fields of application for rapid prototyping in biomedical engineering and health sciences, as well as on the most remarkable challenges and research trends

Optical impression method to measure three-dimensional position and orientation of dental implants using an optical tracker

Objectives: The aim of this study was to devise an optical impression method that could make impressions of dental implants accurately and rapidly. Materials and methods: Four paper markers (4 × 3 mm, 8 × 6 mm, 16 × 12 mm, and 24 × 18 mm) and one titanium marker (8 × 6 mm) were prepared to determine the measuring accuracy of the three-dimensional optical tracker. For a proposed and conventional impression taking method, we compared the reproduction accuracies of the positions and orientations of dental implants and the times to obtain impressions. Finally, we fabricated computer-aided designing (CAD)/computer-aided manufacturing (CAM) superstructure frameworks to determine the adaptation accuracy. Results: The 8 × 6-mm titanium marker was optimal among the prepared markers. Dental implants made by the proposed and conventional impression taking methods had measurement errors of 71 ± 31 μm and 32 ± 18 μm, respectively. The proposed method took a significantly shorter time to obtain an impression than did the conventional method. The connection between the CAD/CAM superstructure frameworks and four implant analogs had uplifts of 55 ± 10 μm, 94 ± 35 μm, 2 ± 1 μm, and 66 ± 3 μm. Conclusion: Our proposed method and fabricated titanium markers enabled us to measure the positions and orientations of dental implants both accurately and rapidly. We then used the reproducible measurement results for the positions and orientations of the dental implants to fabricate CAD/CAM superstructure frameworks within an acceptable accuracy range. © 2012 John Wiley & Sons A/S.This is the pre-peer reviewed version of the following article: Ono S., Yamaguchi S., Kusumoto N., et al. Optical impression method to measure three-dimensional position and orientation of dental implants using an optical tracker. Clinical Oral Implants Research 24, 1117 (2013), which has been published in final form at https://doi.org/10.1111/j.1600-0501.2012.02519.x.. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

Metal artifact reduction in dental CT images using polar mathematical morphology

Most dental implant planning systems use a 3D representation of the CT scan of the patient under study as it provides a more intuitive view of the human jaw. The presence of metallic objects in human jaws, such as amalgam or gold fillings, provokes several artifacts like streaking and beam hardening which makes the reconstruction process difficult. In order to reduce these artifacts, several methods have been proposed using the raw data, directly obtained from the tomographs, in different ways. However, in DICOM-based applications this information is not available, and thus the need of a new method that handles this task in the DICOM domain. The presented method performs a morphological filtering in the polar domain yielding output images less affected by artifacts (even in cases of multiple metallic objects) without causing significant smoothing of the anatomic structures, which allows a great improvement in the 3D reconstruction. The algorithm has been automated and compared to other image denoising methods with successful results. (C) 2010 Elsevier Ireland Ltd. All rights reserved.This work has been supported by the project MIRACLE (DPI2007-66782-C03-01-AR07) of Spanish Ministerio de Educacion y Ciencia.Naranjo Ornedo, V.; Llorens Rodríguez, R.; Alcañiz Raya, ML.; López-Mir, F. (2011). Metal artifact reduction in dental CT images using polar mathematical morphology. Computer Methods and Programs in Biomedicine. 102(1):64-74. https://doi.org/10.1016/j.cmpb.2010.11.009S6474102

Three-Dimensional Cell and Tissue Patterning in a Strained Fibrin Gel System

Techniques developed for the in vitro reproduction of three-dimensional (3D) biomimetic tissue will be valuable for investigating changes in cell function in tissues and for fabricating cell/matrix composites for applications in tissue engineering techniques. In this study, we show that the simple application of a continuous strain to a fibrin gel facilitates the development of fibril alignment and bundle-like structures in the fibrin gel in the direction of the applied strain. Myoblasts cultured in this gel also exhibited well-aligned cell patterning in a direction parallel to the direction of the strain. Interestingly, the direction of cell proliferation was identical to that of cell alignment. Finally, the oriented cells formed linear groups that were aligned parallel to the direction of the strain and replicated the native skeletal muscle cell patterning. In addition, vein endothelial cells formed a linear, aligned vessel-like structure in this system. Thus, the system enables the in vitro reproduction of 3D aligned cell sets replicating biological tissue patterns