Lung adenocarcinoma with micropapillary component presenting with metastatic scrotum tumor and cancer-to-cancer metastasis: A case report

A 54-year-old man was admitted to the hospital presenting with a 3-month history of sclerosing dermal lesion in the external genitalia. A scrotal skin biopsy revealed a poorly-differentiated adenocarcinoma, immunohistochemically positive for cytokeratin 7 (CK7) and for thyroid transcription factor 1 (TTF-1), and negative for CK20. One month after admission, he died of respiratory failure. At autopsy, a consolidating lesion with vague margin was noted in the left lung as well as a well-circumscribed nodule in the right lobe of the thyroid. Histopathologically, pulmonary lesion was adenocarcinoma with a micropapillary component. On the other hand, thyroid tumor was diagnosed as a follicular variant of papillary carcinoma with foci of micropapillary adenocarcinoma. Positive immunohistochemistry for surfactant protein on micoropapillary component was useful to confirm that micropapillary component was of lung adenocarcinoma origin

Fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21: a case report

We report a case of fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21. A stillborn baby, delivered at 15 weeks and 5 days of gestation, had a huge nuchal cystic hygroma. Autopsy revealed aortic coarctation of the periductal type with patent ductus arteriosus, endocardial cushion defect and left ventricular hypoplasia. Trisomy 21 was evident by karyotyping. Macroscopically, while an apparent association of nuchal cystic hygroma and aortic coarctation resembled Turner syndrome, histopathological findings were those typically seen in trisomy 21: numerous dilated lymphatics in the subcutaneous tissue with severe mesenchymal edema, and an enlarged jugular lymphatic sac

Fatal cardiac tamponade due to coronary sinus thrombosis in acute lymphoblastic leukaemia: a case report

We report a rare case of fatal cardiac tamponade attributed to coronary sinus thrombosis. An 83-year-old man was admitted to the hospital complaining of general fatigue. Laboratory examination revealed marked increase of atypical lymphoblastic cells in peripheral blood. CHOP therapy was started under the diagnosis of acute lymphoblastic leukemia. The patient died, however, of sudden cardiac arrest in the initial course of the chemotherapy. Autopsy revealed cardiac tamponade with markedly dilated and congested coronary vein induced by coronary sinus thrombosis. A condition similar to leukemia-related venous thromboembolic disease, combined with endothelial damage induced by leukemic infiltration, may cause this rare complication

Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report

We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in the lower abdominal wall. An excisional biopsy revealed a non-caseous epithelioid granuloma consisting of CD-68 positive histiocytic cells with infiltration of T-lymphocytes and eosinophils; skin metastasis from prostatic adenocarcinoma was ruled out through histological and immunohistochemical analysis. Generally, granulomas may be caused by delayed-type hypersensitivity to the constituents of leuprorelin acetate injections

Type-Ia Supernova Remnant Shell At Z=3.5Z=3.5 Seen In The Three Sightlines Toward The Gravitationally Lensed Qso B1422+231

Using the Subaru 8.2m Telescope with an IRCS Echelle spectrograph, we obtained high-resolution (R=10,000) near-infrared (1.01-1.38 \mu m) spectra of images A and B of the gravitationally lensed QSO B1422+231 (z=3.628) consisting of four known lensed images. We detected MgII absorption lines at z=3.54, which show a large variance of column densities (~ 0.3 dex) and velocities (~ 10 km/s) between the sightlines A and B with a projected separation of only 8.4h_{70}^{-1} pc at the redshift. This is the smallest spatial structure of the high-z gas clouds ever detected after Rauch et al. found a 20-pc scale structure for the same z=3.54 absorption system using optical spectra of images A and C. The observed systematic variances imply that the system is an expanding shell as originally suggested by Rauch et al. By combining the data for three sightlines, we managed to constrain the radius and expansion velocity of the shell (~ 50-100 pc, 130 km/s), concluding that the shell is truly a supernova remnant (SNR) rather than other types of shell objects, such as a giant HII region. We also detected strong FeII absorption lines for this system, but with much broader Doppler width than that of \alpha-element lines. We suggest that this FeII absorption line originates in a localized FeII-rich gas cloud that is not completely mixed with plowed ambient interstellar gas clouds showing other \alpha-element low-ion absorption lines. Along with the Fe richness, we conclude that the SNR is produced by an SNIa explosion.Comment: 16 pages, 15 figures, to be published in The Astrophysical Journa