A BIBLIOMETRIC OVERVIEW OF TRANSFORMATIONAL LEADERSHIP – PERFORMANCE RELATIONSHIP

Previous research highlighted undoubtedly positive impact of transformational leadership on a wide range of performance, including its follower, individual and organizational levels. However, the focus to date has mainly been on the concept’s empirical underpinnings and, hence, the purpose of this study is to present and clarify the intellectual structure of transformational leadership – performance relationship studies. Building on the bibliometric analysis, we have provided the information on publishing trends, the most prolific countries and authors that shape this relationship, whereas term analysis provides a taxonomy for ongoing and recommended upcoming research in the field. The results showed a) the field is under a surprisingly strong influence of a diversified research context along with the focus on the well-recognized and expected Anglo-American region; b) there are five clusters which have been recognized as representatives of the field; c) scarcity of research into sales and managerial performance has been identified which indicates that there is considerable potential for wide-ranging research in fields of marketing and management in general. In the context of contribution, this study provides a reference to researchers entering this field, as well as guidance for future research

Evolving Role for Pharmacotherapy in NAFLD/NASH

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent, dynamic disease that occurs across the age spectrum and can lead to cirrhosis and hepatocellular carcinoma. There are currently no US Food and Drug Administration (FDA) approved treatments for NAFLD; however, this is a field of active research. This review summarizes emerging pharmacotherapies for the treatment of adult and pediatric NAFLD. Investigated pharmacotherapies predominantly target bile acid signaling, insulin resistance, and lipid handling within the liver. Three drugs have gone on to phase III trials for which results are available. Of those, obeticholic acid is the single agent that demonstrates promise according to the interim analyses of the REGENERATE trial. Obeticholic acid showed reduction of fibrosis in adults with nonalcoholic steatohepatitis (NASH) taking 25 mg daily for 18 months (n = 931, reduction in fibrosis in 25% vs. 12% placebo, P \u3c 0.01). Ongoing phase III trials include REGENERATE and MAESTRO-NASH, which investigates thyroid hormone receptor-β agonist MGL-3196. Outcomes of promising phase II trials in adults with NASH are also available and those have investigated agents, including the fibroblast growth factor (FGF)19 analogue NGM282, the GLP1 agonist liraglutide, the FGF21 analogue Pegbelfermin, the sodium glucose co-transporter 2 inhibitor Empagliflozin, the ketohexokinase inhibitor PF-06835919, the acetyl-coenzyme A carboxylase inhibitor GS-0976, and the chemokine receptor antagonist Cenicriviroc. Completed and ongoing clinical trials emphasize the need for a more nuanced understanding of the phenotypes of subgroups within NAFLD that may respond to an individualized approach to pharmacotherapy

The Analysis of Traffic Flow on the Three-leg Intersection – Case Study Cazin

This paper deals with the analysis of traffic on the three-leg intersection in the city Cazin, at the junction of the three-leg intersection. The main issue of this research refers to the left-turn of vehicles coming from the merging road of the given intersection. The extensive analysis covered the current state of traffic flow by using the software tool, SIDRA INTERSECTION program. Within the suggested measures of improvement, the construction of a unsignalised roundabout was proposed. Implementation of the construction of a unsingalised roundabout would increase the level of traffic safety, reduce time losses while taking a left turn and therefore improve the Level of Service (LOS) as a qualitative indicator of traffic flow.&nbsp

Social semantic search : a case study on web 2.0 for science

When researchers formulate search queries to find relevant content on the Web, those queries typically consist of keywords that can only be matched in the content or its metadata. The Web of Data extends this functionality by bringing structure and giving well-defined meaning to the content and it enables humans and machines to work together using controlled vocabularies. Due the high degree of mismatches between the structure of the content and the vocabularies in different sources, searching over multiple heterogeneous repositories of structured data is considered challenging. Therefore, the authors present a semantic search engine for researchers facilitating search in research related Linked Data. To facilitate high-precision interactive search, they annotated and interlinked structured research data with ontologies from various repositories in an effective semantic model. Furthermore, the authors' system is adaptive as researchers can synchronize using new social media accounts and efficiently explore new datasets

Nintendo Wii Remote Controller in Higher Education: Development and Evaluation of a Demonstrator Kit for e-Teaching

The increasing availability of game based technologies together with advances in Human-Computer Interaction (HCI) and usability engineering provides new challenges and opportunities to virtual environments in the context of e-Teaching. Consequently, an evident trend is to offer learners with the equivalent of practical learning experiences, whilst supporting creativity for both teachers and learners. Current market surveys showed surprisingly that the Wii remote controller (Wiimote) is more widely spread than standard PCs and is the most used computer input device worldwide, which given its collection of sensors, accelerometers and bluetooth technology, makes it of great interest for HCI experiments in e-Learning/e-Teaching. In this paper we discuss the importance of gestures for teaching and describe the design and development of a low-cost demonstrator kit based on Wiimote enhancing the quality of the lecturing with gestures

Editorial:FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans

Obesity is a global pandemic that requires the urgent development of therapies and prevention strategies. To define new pharmacologic therapies or nutritional approaches it is mandatory to find new targets. Fibroblast growth factor 21 (FGF21) is considered a potential target to treat obesity, due to its favorable metabolic activity, signalling pathways and regulatory mechanisms. It is well-documented that FGF21 is induced by a wide range of biological stress conditions and a key signal that communicates and coordinates the physiologic response to restore the metabolic homeostasis in different tissues (1). FGF21 is elevated in pathological conditions such as obesity, insulin resistance, or fatty liver disease where an impairment of its signalling has been described (2). On the other hand, FGF21 analogues tested in overweight/obese patients with type 2 diabetes or NAFLD/NASH can reduce dyslipidaemia and steatosis, but improvements in glycaemic control or body weight were not globally restored (3). This suggests that pharmacologic effects of FGF21 are different from its physiological effects. In this Research Topic “FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans”, we include publications related to new advances involving FGF21, its signalling pathway, and its potential as a target to treat obesityinfo:eu-repo/semantics/publishedVersio

@twitter analysis of #edmedia10 – is the #informationstream usable for the #mass

In this paper we report the use of an application that enables an automatic analyses of social media content. In this early stage of development our work focuses on data from Twitter1 as currently to be the most popular and fastest growing microblogging platform. After an introduction about a general concept the conference tweets of a big e-learning conference are examined. It is aimed to show whether there is a possibility to get significant information from a pool of postings or not. The publication concludes that a keyword extraction can be taken as basis for further investigations and treatment of data

Visualizing collaborations and online social interactions at scientific conferences for scholarly networking

The various ways of interacting with social media, web collaboration tools, co-authorship and citation networks for scientific and research purposes remain distinct. In this paper, we propose a solution to align such information. We particularly developed an exploratory visualization of research networks. The result is a scholar centered, multi-perspective view of conferences and people based on their collaborations and online interactions. We measured the relevance and user acceptance of this type of interactive visualization. Preliminary results indicate a high precision both for recognized people and conferences. The majority in a group of test-users responded positively to a set of statements about the acceptance