A compilation of data on the thermal stratification at the central station in the northern North Sea during FLEX '76

A first survey of the entire temperature data base from the central station is presented. The development and the changes of the sea surface temperature, the thermocline, and the heat content due to meteorological forces, are described

Ein numerisches Modellsystem zur Vorhersage der Drift und Ausbreitung von Oel in der Deutschen Bucht

25 maps.TIB Hannover: RN 8908(90-081) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Fibrocystin Is Essential to Cellular Control of Adhesion and Epithelial Morphogenesis

Mutations of the Pkhd1 gene cause autosomal recessive polycystic kidney disease (ARPKD). Pkhd1 encodes fibrocystin/polyductin (FPC), a ciliary type I membrane protein of largely unknown function, suggested to affect adhesion signaling of cells. Contributions of epithelial cell adhesion and contractility to the disease process are elusive. Here, we link loss of FPC to defective epithelial morphogenesis in 3D cell culture and altered cell contact formation. We study Pkhd1-silenced Madin-Darby Canine Kidney II (MDCKII) cells using an epithelial morphogenesis assay based on micropatterned glass coverslips. The assay allows analysis of cell adhesion, polarity and lumen formation of epithelial spheroids. Pkhd1 silencing critically affects the initial phase of the morphogenesis assay, leading to a reduction of correctly polarized spheroids by two thirds. Defects are characterized by altered cell adhesion and centrosome positioning of FPC-deficient cells in their 1-/2-cell stages. When myosin II inhibitor is applied to reduce cellular tension during the critical early phase of the assay, Pkhd1 silencing no longer inhibits formation of correctly polarized epithelia. We propose that altered sensing and cell interaction of FPC-deficient epithelial cells promote progressive epithelial defects in ARPKD

Ausbreitung und Vermischung von Schadstoffen in der Deutschen Bucht Eine numerische Simulation

TIB: RN 8908 (82-135) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman