210 research outputs found
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins
SummaryBefore transmitter-filled synaptic vesicles can fuse with the plasma membrane upon stimulation they have to be primed to fusion competence. The regulation of this priming process controls the strength and plasticity of synaptic transmission between neurons, which in turn determines many complex brain functions. We show that CAPS-1 and CAPS-2 are essential components of the synaptic vesicle priming machinery. CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, which causes a selective impairment of fast phasic transmitter release. Increases in the intracellular Ca2+ levels can transiently revert this defect. Our findings demonstrate that CAPS proteins generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca2+ triggered release of transmitters
Switching between dynamic states in intermediate-length Josephson junctions
The appearance of zero-field steps (ZFS’s) in the current-voltage characteristics of intermediate-length overlap-geometry Josephson tunnel junctions described by a perturbed sine-Gordon equation (PSGE) is associated with the growth of parametrically excited instabilities of the McCumber background curve (MCB). A linear stability analysis of a McCumber solution of the PSGE in the asymptotic linear region of the MCB and in the absence of magnetic field yields a Hill’s equation which predicts how the number, locations, and widths of the instability regions depend on the junction parameters. A numerical integration of the PSGE in terms of truncated series of time-dependent Fourier spatial modes verifies that the parametrically excited instabilities of the MCB evolve into the fluxon oscillations characteristic of the ZFS’s. An approximate analysis of the Fourier mode equations in the presence of a small magnetic field yields a field-dependent Hill’s equation which predicts that the major effect of such a field is to reduce the widths of the instability regions. Experimental measurements on Nb-NbxOy-Pb junctions of intermediate length, performed at different operating temperatures in order to vary the junction parameters and for various magnetic field values, verify the physical existence of switching from the MCB to the ZFS’s. Good qualitative, and in many cases quantitative, agreement between analytic, numerical, and experimental results is obtained
Superconductivity enhanced conductance fluctuations in few layer graphene nanoribbons
We investigate the mesoscopic disorder induced rms conductance variance
in a few layer graphene nanoribbon (FGNR) contacted by two
superconducting (S) Ti/Al contacts. By sweeping the back-gate voltage, we
observe pronounced conductance fluctuations superimposed on a linear background
of the two terminal conductance G. The linear gate-voltage induced response can
be modeled by a set of inter-layer and intra-layer capacitances.
depends on temperature T and source-drain voltage .
increases with decreasing T and . When lowering , a
pronounced cross-over at a voltage corresponding to the superconducting energy
gap is observed. For |V_{sd}|\ltequiv \Delta the fluctuations are
markedly enhanced. Expressed in the conductance variance of one
graphene-superconducutor (G-S) interface, values of 0.58 e^2/h are obtained at
the base temperature of 230 mK. The conductance variance in the sub-gap region
are larger by up to a factor of 1.4-1.8 compared to the normal state. The
observed strong enhancement is due to phase coherent charge transfer caused by
Andreev reflection at the nanoribbon-superconductor interface.Comment: 15 pages, 5 figure
Subharmonic Shapiro steps and assisted tunneling in superconducting point contacts
We analyze the current in a superconducting point contact of arbitrary
transmission in the presence of a microwave radiation. The interplay between
the ac Josephson current and the microwave signal gives rise to Shapiro steps
at voltages V = (m/n) \hbar \omega_r/2e, where n,m are integer numbers and
\omega_r is the radiation frequency. The subharmonic steps (n different from 1)
are a consequence of the ocurrence of multiple Andreev reflections (MAR) and
provide an unambiguous signature of the peculiar ac Josephson effect at high
transmission. Moreover, the dc current exhibits a rich subgap structure due to
photon-assisted MARs.Comment: Revtex, 4 pages, 4 figure
Isotope Effect in the Presence of Magnetic and Nonmagnetic Impurities
The effect of impurities on the isotope coefficient is studied theoretically
in the framework of Abrikosov-Gor'kov approach generalized to account for both
potential and spin-flip scattering in anisotropic superconductors. An
expression for the isotope coefficient as a function of the critical
temperature is obtained for a superconductor with an arbitrary contribution of
spin-flip processes to the total scattering rate and an arbitrary degree of
anisotropy of the superconducting order parameter, ranging from isotropic
s-wave to d-wave and including anisotropic s-wave and mixed (s+d)-wave as
particular cases. It is found that both magnetic and nonmagnetic impurities
enhance the isotope coefficient, the enhancement due to magnetic impurities
being generally greater than that due to nonmagnetic impurities. From the
analysis of the experimental results on La-Sr-Cu-M-O high temperature
superconductor, it is concluded that the symmetry of the pairing state in this
system differs from a pure d-wave.Comment: 4 pages, 3 figure
Isotope Effect for the Penetration Depth in Superconductors
We show that various factors can lead to an isotopic dependence of the
penetration depth . Non-adiabaticity (Jahn-Teller crossing) leads to
the isotope effect of the charge carrier concentration and, consequently,
of in doped superconductors such as the cuprates. A general equation
relating the isotope coefficients of and of is presented for
London superconductors. We further show that the presence of magnetic
impurities or a proximity contact also lead to an isotopic dependence of
; the isotope coefficient turns out to be temperature dependent,
, in these cases. The existence of the isotope effect for the
penetration depth is predicted for conventional as well as for high-temperature
superconductors. Various experiments are proposed and/or discussed.Comment: 11 pages, 8 figures, accepted for publication in Phys. Rev.
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