Potential skin problems of diabetes mellitus patients: a review

Diabetes mellitus (DM) is one of the common metabolic disorders, and a major part of chronic diseases, the prevalence of which tends to increase due to multifactor. Blood vessels, kidneys, lungs, and skin are among the organs that are affected. The first problem that arises, or commonly exists among one-third of diabetics, are problems with their skin, although skin lesions may develop along with the progress of the disease, or can occur during the later phase of DM. The prevalence and symptoms of skin problems in type 1 DM (T1DM) and type 2 DM (T2DM) are often unclear, and at the beginning of the course of the diseases they often go undiagnosed. Several theories regarding the pathophysiology of DM can be used as a logical reference for the early identification and diagnosis of skin problems, aimed at preventing the worsened condition. The use of skin autofluorescence (SAF) and AGEs reader in several cases of skin problems, can also be an important marker as an adjunct to predict the possibility and progressiveness of DM. Skin problems linked to patients with DM can be categorized as strongly related to diabetes, non-specific and related to DM, skin infection in DM, and skin problems due to diabetic medication. With the current COVID-19 pandemic, there are additional demands for more critical investigation of skin problems in patients with DM. The skin problems that occur in DM may need to be examined from the early stage and it is necessary to inhibit the progression of skin problems, as well as to consider the need for multidisciplinary DM therapy

Faktor Risiko Kejadian Kusta di Kabupaten Lamongan

Risk factors of leprosy in district of LamonganPurposeThis study aimed to know the risk factors of leprosy incidence in Lamongan district including economic status or family income, BCG vaccination, residential density, floor conditions, source of water, contact history, bathing habit using soap and using footwear. MethodsThe research was a case-control study. The subjects were the people who had clinical or laboratory symptoms, leprosy diagnosed and recorded in the health center register. The samples were 170 people, consisting of 85 cases and 85 controls. The data were analysed using chi-square and logistic regression tests, and the amount of the risk was calculated using odds ratio. ResultsThe risk-factors associated with the incidence of leprosy in Lamongan were the economic status or family income (OR=4.3 and p=0.001), BCG vaccination (OR=4.3 and p=0.050), residential density (OR=3.2 and p=0.001), floor conditions (OR=2.8 and p=0.051), source of water (OR=2.1 and p=0.033), contact history (OR=7.8 and p=0.001), bathing habit using soap (OR=3.1 and p=0.022) and using footwear (OR=3.1 and p=0.004). The dominant risk factor was BCG vaccination (OR = 8.1 and p=0.025). ConclusionThere were correlations between leprosy incidence and the economic status or family income, BCG vaccination, residential density, floor conditions, source of water, contact history, bathing habit using soap and using footwear. The dominant risk factor was BCG vaccination

Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases

In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From the study, it is found that global diseases, like Crohn’s disease, rheumatoid arthritis, Graves’ disease, gelatin allergy, T1D, HIV, systemic lupus erythematosus, juvenile chronic arthritis, and Mycobacterial disease (tuberculosis and leprosy) suspected associated with the Indonesian HLA profiles

Correlation between Leprosy Children with Nutritional Status, Personal Hygiene, BCG Vaccination History and Occupancy Density in Gresik Regency

Abstract FRS Prakoeswa, DI Haerani, UD Ratnaasri, illustrator, Santi Martini, H Soebono, D Husada, HB Notobroto, MY Listiawan, A Endaryanto, CRS Prakoeswa Even though Indonesia has achieved elimination status, leprosy is still an important health problem in Indonesia because of its debilitating nature. East Java is one of the provinces with the highest leprosy burden in Indonesia, with a high percentage of children cases. Many factors are thought to affect leprosy transmission. Among them are nutritional status, personal hygiene, BCG vaccination history, and occupancy density. The purpose of this study was to determine the relationship between nutritional status, personal hygiene, BCG vaccination history, and occupancy density with the incidence of leprosy in children in the Gresik Regency. This is an analytic observational research with a case-control approach. This research was conducted in December 2019. The number of samples were 60 respondents, consisting of 30 cases and 30 controls. The results of multivariate analysis showed that there was a relationship between nutritional status (p = 0.041; OR = 9,628), history of BCG vaccination (p = 0.032; OR = 22,164) and occupancy density (p = 0.003; OR = 14,810) with leprosy in children. Nutritional status, personal hygiene, BCG vaccination history, and occupancy density are significantly associated with the incidence of leprosy in children, with occupancy density as the most significant factor and history of BCG vaccination as the strongest risk predictor associated with the development of leprosy in the pediatric populatio

Inventory of the chemicals and the exposure of the workers’ skin to these at two leather factories in Indonesia

PURPOSE: Tannery workers are exposed to hazardous chemicals. Tannery work is outsourced to newly industrialized countries (NICs) where attention into occupational health hazards is limited. In this study, we investigated the skin exposure to hazardous chemicals in tannery workers and determined the prevalence of occupational skin diseases (OSDs) at tanneries in a NIC. METHODS: A cross-sectional study on the observation of the working process and an inventory and risk assessment of the chemicals used. Classification of chemicals as potential sensitizers/irritants and a qualitative assessment of exposure to these chemicals. Workers were examined and interviewed using Nordic Occupational Skin Questionnaire-2002/LONG. RESULTS: The risk of OSDs at the investigated tanneries was mainly related to the exposure of the workers' skin to chemicals in hot and humid environmental conditions. In 472 workers, 12% reported a current OSD and 9% reported a history of OSD. In 10% of all cases, an OSD was confirmed by a dermatologist and 7.4% had an occupational contact dermatitis (OCD). We observed that personal protective equipment (PPE) used was mainly because of skin problems in the past and not as a primary protection against OSD. CONCLUSION: We observed a high frequency and prolonged exposure to many skin hazardous factors in tannery work although PPE was relatively easily available and which was generally used as a secondary preventative measure. The observed point-prevalence in this study was at the same level as that reported for other high-risk OSDs in Western countries and other tanneries in NICs. However, the observed point-prevalence in this study was lower than that reported in India and Korea. The results of our study and those of other studies at tanneries from other NICs were probably influenced by Healthy Worker Survivor Effect (HWSE)

Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population

<p>Abstract</p> <p>Background</p> <p>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to <it>Mycobacterium leprae</it>. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.</p> <p>Methods</p> <p>The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.</p> <p>Results</p> <p>The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.</p> <p>Conclusion</p> <p>HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.</p

A seroepidemiological study of leprosy in high- and low-endemic Indonesian villages

A seroepidemiological study was performed in three different leprosy-endemic areas in Indonesia, including two isolated villages with high endemicity in South Sulawesi (Kaluarang and Hulo) and an area with low endemicity in Java (Jepara). A total of 2430 serum samples were collected from 2672 individuals in these locations. The prevalence of leprosy in these three areas, as determined during this study, was 29/1000, 11/1000, and 7/1000 in Kaluarang, Hulo and Jepara, respectively. Two serological assays were employed in this study to detect antibodies against Mycobacterium leprae. One is an enzyme-linked immunosorbent assay (ELISA) based on the detection of antibodies to the species-specific epitope of phenolic glycolipid-I (PGL-I) of M. leprae. The second test, using inhibition of an ELISA reaction (ELISA-INH) detects antibodies to a species-specific epitope on the 36-kDa protein antigen of M. leprae. In comparison with clinical findings, the specificity of both serological tests was calculated to be 91%. The sensitivity of the ELISA was 97.6% for multibacillary (MB) cases and 56.8% for paucibacillary (PB) cases; for the ELISA-INH, it was 97.6% and 81.8% for MB and PB cases, respectively. Seropositivity rates were shown to be unrelated to sex, to Mitsuda skin-test reactivity, or to BCG vaccination status. The pattern of seropositivity was, however, clearly age-related, with high seropositivity in the age group 10-19 years and decreasing rates of positivity in the older age groups. Age-standardized seropositivity ratios were not correlated to the prevalence of leprosy when comparing the three areas. Therefore, it is not yet clear whether or not seropositivity reflects infection. If it does, other, as yet unidentified, factors may play a role in the natural history of the diseas