Das Ländliche als kulturelle Kategorie: aktuelle kulturwissenschaftliche Perspektiven auf Stadt-Land-Beziehungen

Das Ländliche hat Konjunktur. Zwischen medialer »Landlust« und realem Strukturwandel in den ländlichen Räumen Europas differenziert es sich dynamisch aus. Idylle oder Problemregion? Arbeitsort oder Freizeitpark? Repräsentationen und lebensweltliche Erfahrungen des Ländlichen avancieren zu einem alltagskulturellen Konfliktfeld, auf dem sich vor einem historischen Hintergrund elementare Problemlagen der Gegenwart und die Komplexität von kulturellen Land-Stadt-Beziehungen spiegeln.Die Beiträge des Bandes liefern hierzu Einsichten aus der Forschungsperspektive der Europäischen Ethnologie und rahmen das Thema damit für historische und gegenwartsbezogene Kulturanalysen begrifflich, methodisch und theoretisch

The German National Registry of Primary Immunodeficiencies (2012-2017)

Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment