An interactive layout exploration and optimisation method for early stage ship design

This paper presents a novel, highly interactive genetic algorithm-based layout exploration and optimisation method for generating spatial configurations of ships in the early stages of the design process. The method draws upon the principles of design-driven architecturally centred ship design processes by enabling the naval architects to make important decisions in a hybrid design process. The method utilises a genetic algorithm-based optimisation tool to rapidly generate and evaluate a diverse set of general arrangement options. It is approached in stages where each stage comprises two steps (manual and automatic). The new genetic algorithm-based layout optimisation tool is demonstrated by being applied to an Offshore Patrol Vessel test case. The advantages and disadvantages of the proposed tool are discussed, as well as the current limitations of the overall approach and future work

Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes

Aims: We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results: This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08–1.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83–1.07). In participants with diabetes, people with high triglycerides (200–499 mg/dL) had a 44% (HR, 1.44; 95% CI, 1.12–1.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (<150 mg/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications. Conclusion: This study demonstrates that fasting triglycerides of ≥200 mg/dL are associated with an increased risk of CVD mortality in patients with diabetes but not in those without diabetes. Future clinical trials of new treatments to lower triglycerides should focus on patients with diabetes

Nitrite is produced by elicited but not by circulating neutrophils

The generation of nitrite (NO2-) was used as an index of the production of nitric oxide by human and rat polymorphonuclear leukocytes (PMN) and rat peritoneal macrophages. Human peripheral blood PMN did not produce significant levels of NO2-. Attempts to induce NO2- generation in human PMN by incubation with GM–CSF (1 nM), TNFα (0.3 nM), endotoxin (1 μg/ml) or formyl-Met-Leu-Phe (100 nM) for up to 16 h were not successful. Addition of human PMN primed by GM–CSF (1 nM) to rabbit aortic ring preparations precontracted with phenylephrine had no effect on tone. In contrast to these observations, PMN, isolated from the peritoneum of oyster glycogen treated rats, generated NO2- via a pathway sensitive to inhibition by the nitric oxide synthase inhibitor, NG-monomethyl L-arginine. However, peripheral blood rat PMN obtained from the same animals did not produce NO2-, even during prolonged incubation for periods of up to 16 h. It is suggested that detectable NO production by PMN requires NO synthase activity to be induced either by the process of PMN migration or by exposure to certain cytokines produced locally at the site of inflammation

Dietary fatty acids and mortality risk from heart disease in US adults: an analysis based on NHANES

We investigated the association of dietary intake of major types of fatty acids with heart disease mortality in a general adult cohort with or without a prior diagnosis of myocardial infarction (MI). This cohort study included US adults who attended the National Health and Nutrition Examination Surveys from 1988 to 2014. Heart disease mortality was ascertained by linkage to the National Death Index records through 31 December 2015. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of fatty acid intake for heart disease mortality. This cohort included 45,820 adults among which 1,541 had a prior diagnosis of MI. Participants were followed up for 532,722 person-years (mean follow-up, 11.6 years), with 2,313 deaths recorded from heart disease being recorded. Intake of saturated (SFAs) and monounsaturated fatty acids (MUFAs) was associated with heart disease mortality after adjustment for all the tested confounders. In contrast, a 5% higher calorie intake from polyunsaturated fatty acids (PUFAs) was associated with a 9% (HR, 0.91; 95% CI 0.83–1.00; P = 0.048) lower multivariate-adjusted risk of heart disease mortality. Sub-analyses showed that this inverse association was present in those without a prior diagnosis of MI (HR,0.89; 95% CI 0.80–0.99) but not in those with the condition (HR, 0.94; 95% CI 0.75–1.16). The lack of association in the MI group could be due to a small sample size or severity and procedural complications (e.g., stenting and medication adherence) of the disease. Higher PUFA intake was associated with a favourable lipid profile. However, further adjustment for plasma lipids did not materially change the inverse association between PUFAs and heart disease mortality. Higher intake of PUFAs, but not SFAs and MUFAs, was associated with a lower adjusted risk of heart disease mortality in a large population of US adults supporting the need to increase dietary PUFA intake in the general public

Long Term Variability of a Black Widow's Eclipses -- A Decade of PSR J2051−-0827

In this paper we report on $\sim10$ years of observations of PSR J2051$-$0827, at radio frequencies in the range 110--4032 MHz. We investigate the eclipse phenomena of this black widow pulsar using model fits of increased dispersion and scattering of the pulsed radio emission as it traverses the eclipse medium. These model fits reveal variability in dispersion features on timescales as short as the orbital period, and previously unknown trends on timescales of months--years. No clear patterns are found between the low-frequency eclipse widths, orbital period variations and trends in the intra-binary material density. Using polarisation calibrated observations we present the first available limits on the strength of magnetic fields within the eclipse region of this system; the average line of sight field is constrained to be $10^{-4}$ G $\lesssim B_{||} \lesssim 10^2$ G, while for the case of a field directed near-perpendicular to the line of sight we find $B_{\perp} \lesssim 0.3$ G. Depolarisation of the linearly polarised pulses during the eclipse is detected and attributed to rapid rotation measure fluctuations of $\sigma_{\text{RM}} \gtrsim 100$ rad m$^{-2}$ along, or across, the line of sights averaged over during a sub-integration. The results are considered in the context of eclipse mechanisms, and we find scattering and/or cyclotron absorption provide the most promising explanation, while dispersion smearing is conclusively ruled out. Finally, we estimate the mass loss rate from the companion to be $\dot{M}_{\text{C}} \sim 10^{-12} M_\odot$ yr$^{-1}$, suggesting that the companion will not be fully evaporated on any reasonable timescale

The Low-Frequency Radio Eclipses of the Black Widow Pulsar J1810+1744

We have observed and analysed the eclipses of the black widow pulsar J1810+1744 at low radio frequencies. Using LOw-Frequency ARray (LOFAR) and Westerbork Synthesis Radio Telescope observations between 2011--2015 we have measured variations in flux density, dispersion measure and scattering around eclipses. High-time-resolution, simultaneous beamformed and interferometric imaging LOFAR observations show concurrent disappearance of pulsations and total flux from the source during the eclipses, with a $3\sigma$ upper limit of 36 mJy ($<10\%$ of the pulsar's averaged out-of-eclipse flux density). The dispersion measure variations are highly asymmetric, suggesting a tail of material swept back due to orbital motion. The egress deviations are variable on timescales shorter than the 3.6 hr orbital period and are indicative of a clumpy medium. Additional pulse broadening detected during egress is typically $<20\%$ of the pulsar's spin period, showing no evidence of scattering the pulses beyond detectability in the beamformed data. The eclipses, lasting $\sim13\%$ of the orbit at 149 MHz, are shown to be frequency-dependent with total duration scaling as $\propto\nu^{-0.41\pm0.03}$. The results are discussed in the context of the physical parameters of the system, and an examination of eclipse mechanisms reveals cyclotron-synchrotron absorption as the most likely primary cause, although non-linear scattering mechanisms cannot be quantitatively ruled out. The inferred mass loss rate is a similar order-of-magnitude to the mean rate required to fully evaporate the companion in a Hubble time.Comment: 15 pages, 9 figure