9 research outputs found
A multiwire proportional chamber for precision studies of neutron decay angular correlations
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The teacher assessment dilemma: What is versus what ought to be!
- Author
- A. Shanker
- A.C. Porter
- B. Rosenshine
- B.W. Grover
- D.L. Ball
- D.L. Ball
- E.A. Silver
- G. Leinhardt
- G. Leinhardt
- G. R. Anrig
- G.F. Madaus
- H.L. Schoen
- J. Baratz-Snowden
- J. Brophy
- J. Larkin
- J.A. Dossey
- J.D. Bransford
- L. Cuban
- L.B. Resnick
- L.B. Resnick
- L.S. Shulman
- L.S. Shulman
- M.T.H. Chi
- National Council of Teachers of Mathematics Commission on Standards for School Mathematics
- National Research Council
- R.J. Mislevy
- R.L. Pecheone
- S. Lane
- T.A. Romberg
- T.J. Shuell
- T.N. Carraher
- W.G. Chase
- W.S. Hadley
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Common variants in Alzheimerâs disease and risk stratification by polygenic risk scores
- Author
- Aarsland D.
- Abdelnour C.
- Abdelnour C.
- Adarmes-GĂłmez A. D.
- Aguilera N.
- Alarcon E.
- AlarcĂłn-MartĂn E.
- AlarcĂłn-MartĂn E.
- Alcolea D.
- Alegret M.
- Alegret M.
- Alonso M. D.
- Alvarez I.
- Amer-Ferrer G.
- Amouyel P.
- Anastasiou A.
- Anastasiou C.
- Andrade V.
- Andreassen O.A.
- Andreoni S.
- Antequera M.
- Antikainen R.
- Antonell A.
- AntĂșnez C.
- AntĂșnez C.
- Appollonio I.
- Arcaro M.
- Archetti S.
- Arias Pastor A.
- Armstrong N.J.
- Arosio B.
- Assogna F.
- Bacha J.I.
- Bagnoli S.
- Bailly H.
- Banaj N.
- Baquero M.
- Baquero M.
- Bastiani P.
- Belezhanska D.
- Bellenguez C.
- Bellou E.
- Benaque A.
- Benaque A.
- Bennett K.
- Benussi A.
- Benussi L.
- Bernal SĂĄnchez-Arjona M.
- Bernal M.
- Besse C.
- Bessi V.
- Binetti G.
- Bis J.C.
- Bizzarro A.
- Bjerke M.
- Blennow K.
- Blesa R.
- Blesa R.
- Boada M.
- Boada M.
- Boada M.
- Boecker H.
- Boerwinkle E.
- Boland A.
- Borroni B.
- Boschi S.
- BossĂč P.
- Botne Sando S.
- Brayne C.
- Bresner C.
- Brusco L.I.
- Buendia M.
- Buerger K.
- Buiza-Rueda D.
- Buiza-Rueda D.
- Bullido M.J.
- Bullido M.J.
- Burguera J.A.
- Burholt V.
- Caffarra P.
- Calero M.
- Calero M.
- Carracedo A.
- Carracedo Ă.
- Carrillo F.
- CarriĂłn-Claro M.
- Casajeros M.J.
- Castaño E.M.
- Cañabate P.
- Cecchetti R.
- Cervera-Carles L.
- Charbonnier C.
- Chillotti C.
- Chipi E.
- ChĂȘne G.
- Ciccone S.
- Ciullo V.
- Clare L.
- ClarimĂłn J.
- ClarimĂłn J.
- Clark C.
- Conti E.
- CorbatĂłn-Anchuelo A.
- CorbatĂłn-Anchuelo A.
- Cores V.
- Corma-GĂłmez A.
- Costantini E.
- Craig D.
- Cruz-Gamero J.M.
- Cuesta C.
- Custodero C.
- Daian D.
- Dalmasso M.C.
- Daniele A.
- Dardiotis E.
- de Mendonça A.
- de Pancorbo M.M.
- De Roeck E.
- de Rojas I.
- de Rojas I.
- de Rojas I.
- Deckert J.
- del Ser T.
- del Ser T.
- Del Zompo M.
- Deleuze J-F
- Deniz-Naranjo M.C.
- Deramecourt V.
- DeStefano A.L.
- Dichgans M.
- Diego S.
- Diehl-Schmid J.
- Diez-Fairen M.
- Diez-Fairen M.
- Dionigi Rossi P.
- Djurovic S.
- Dufouil C.
- Duron E.
- DĂŒzel E.
- Engelborghs S.
- Escott-Price V.
- Escuela R.
- Esiri M.
- Espinosa A.
- Espinosa A.
- Etchepareborda I.
- Ewers M.
- Farotti L.
- Farrer L.A.
- Fenoglio C.
- FernĂĄndez-Fuertes M.
- Ferrarese C.
- Ferrari Ca.
- Ferreira C.B.
- Ferri E.
- Fin B.
- Fischer P.
- FlieĂbach K.
- Fornage M.
- Fortea J.
- Fortea J.
- Fostinelli S.
- Fox N.C.
- Franco-MacĂas E.
- Franco-MacĂas E.
- Frank-GarcĂa A.
- Frank-GarcĂa A.
- Frikke-Schmidt R.
- Froelich L.
- Gailhajenet A.
- Galeano P.
- Galimberti D.
- Garcia Madrona S.
- Garcia-Ribas G.
- Garcia-Ribas G.
- GarcĂa-Alberca J.M.
- GarcĂa-Alberca J.M.
- GarcĂa-GonzĂĄlez P.
- GarcĂa-GonzĂĄlez P.
- GarcĂa-Madrona S.
- Garrote-Espina L.
- Gelpi E.
- Germani S.
- Ghidoni R.
- Giaccone G.
- Giedraitis V.
- Giegling I.
- Gil S.
- Gil S.
- Goldhardt O.
- GonzĂĄlez-Perez A.
- GonzĂĄlez-PĂ©rez A.
- Graff C.
- Grande G.
- Greco A.
- Grenier-Boley B.
- Grimmer T.
- Grozeva D.
- GrĂŒnblatt E.
- Guitart M.
- GĂłmez-Garre P.
- Haapasalo A.
- Hadjigeorgiou G.
- Haines J.L.
- Hampel H.
- Hanon O.
- Harris J.
- Hartmann A.M.
- Harwood J.
- Hausner L.
- Heilmann-Heimbach S.
- Helisalmi S.
- Heneka M.T.
- HernĂĄndez I.
- HernĂĄndez I.
- HernĂĄndez I.
- Herrman M.J.
- Herrmann M.J.
- Heun R.
- Hevilla S.
- Hiltunen M.
- Hoffmann P.
- Holmans P.A.
- Holmes C.
- Holstege H.
- Hooper N.M.
- Hort J.
- Huerto Vilas R.
- Huisman M.
- Hulsman M.
- HĂ€gg S.
- Ibarria M.
- Ikram M.A.
- Ingelsson M.
- Ingino C.
- Janowitz D.
- Jansen I.E.
- Jansen I.E.
- Jessen F.
- JesĂșs S.
- Jian X.
- Joachim C.
- Johansson C.
- Johnston J.
- Jones M.
- JĂŒrgen D.
- Kalaria R.N.
- Karlsson I.K.
- Kehoe P.G.
- Kern S.
- Kilander L.
- Kinhult StÄhlbom A.
- Kivipelto M.
- Kleineidam L.
- Kochen S.
- Kohler E.
- Kohler M.
- Koivisto A.
- Kok A.A.L.
- Kornhuber J.
- Kosmidis M.H.
- Kosmidis M.H.
- Koutsouraki E.
- Kunkle B.W.
- Kuulasmaa T.
- Kölsch H.
- KĂŒĂ§ĂŒkali F.
- Laatikainen T.
- Labrador Espinosa M.A.
- Lacidogna G.
- Laczo J.
- Lafuente A.
- Lage C.
- Lage C.
- Lambert J-C
- Laske C.
- Lauria A.
- Lebouvier T.
- Legaz A.
- Lehtisalo J.
- Lemstra A.W.
- Leonenko G.
- Lerch O.
- Lindström J.
- Lisetti V.
- Lisso J.
- LleĂł A.
- LleĂł A.
- Lopez de Munain A.
- Lopez de Munain A.
- Love S.
- Luckuck L.
- LĂłpez-GarcĂa S.
- LĂłpez-GarcĂa S.
- Löwenmark M.
- Macias J.
- Macias-GarcĂa D.
- Macleod C.
- MacĂas J.
- Maier W.
- Mangialasche F.
- Mangone C.
- Mann D.M.
- Manzanares S.
- Marianthi A.
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié M.
- Marshall R.
- Martinez C.
- MartĂn Montes A.
- MartĂn Montes A.
- MartĂn E.
- MartĂnez RodrĂguez C.
- MartĂnez B.
- MartĂnez C.
- MartĂnez M. T.
- MartĂnez V.
- MartĂnez-Lage Ălvarez P.
- MartĂnez-Larrad M.T.
- MarĂn M.
- MarĂn T.
- MarĂn-Muñoz J.
- Masullo C.
- Mather K.A.
- Matoska V.
- Matthews F.
- MauleĂłn A.
- Mayeux R.
- McCracken C.
- McGuinness B.
- Mead S.
- Mecocci P.
- Medel N.
- Medina M.
- Medina M.
- Meggy A.
- Mehrabian S.
- Mendioroz Iriarte M.
- Mendoza S.
- Menzies G.
- Menéndez-Gonzålez M.
- Menéndez-Gonzålez M.
- Mihova K.Y.
- Mir P.
- Mir P.
- Molina-Porcel L.
- Molinuevo J.L.
- Montrreal L.
- Montrreal L.
- Morelli L.
- Moreno F.
- Moreno M.
- Moreno-Grau S.
- Moreno-Grau S.
- Morgan K.
- Muchnik C.
- Muñoz-Fernandez C.
- Nacmias B.
- Naj A.C.
- Natunen T.
- Neary D.
- Ngandu T.
- Nicolas G.
- Nordestgaard B.G.
- Novack G.
- Nöthen M.M.
- Olaso R.
- Olivar N.
- Orellana A.
- Orellana A.
- Orsini M.
- Ortega G.
- Ortega G.
- Ortiz C.
- Padovani A.
- Palacio D.L.
- Pancho A.
- Papenberg G.
- Parnetti L.
- Pasquier F.
- Passmore P.
- Pastor A.B.
- Pastor P.
- Pastor P.
- Pedersen N.L.
- PelejĂĄ E.
- Peltonen M.
- Pericak-Vance M.A.
- Periñån-Tocino T.
- Perneczky R.
- Peters O.
- Phillips J.
- Piaceri I.
- Pickering-Brown S.
- Pijnenburg Y.A.L.
- Pineda J. A.
- Pineda J.A.
- Pineda-Sanchez R.
- Piras F.
- Piras F.
- Pisanu C.
- Piñol-Ripoll G.
- Piñol-Ripoll G.
- Polak T.
- Politis D.G.
- Polvikoski T.M.
- Popp J.
- Posthuma D.
- Preckler S.
- Prestia F.A.
- Priller J.
- PĂ©rez Tur J.
- PĂ©rez-Cordon A.
- PĂ©rez-CordĂłn A.
- PĂ©rez-Tur J.
- Quenez O.
- Quintela I.
- Quintela I.
- Rainer M.
- Rainero I.
- Ramirez A.
- Real de AsĂșa D.
- Real L. M.
- Real L.M.
- Reyes Toso C.
- Reynolds C.A.
- Richardson A.
- Riedel-Heller S.
- Riederer P.
- Rios M.
- Roberto N.
- Rodrigo S.
- Rodriguez-Rodriguez E.
- RodrĂguez-RodrĂguez E.
- Rojo M.
- Rongve A.
- Rongve A.
- Rosas Allende I.
- Rosende-Roca M.
- Rosende-Roca M.
- Rossi G
- Roveta F.
- Royo J.L.
- Royo J.L.
- Rubino E.
- Ruiz A.
- Ruiz A.
- Ruiz A.
- Rujescu D.
- RĂĄbano A.
- RĂĄbano A.
- Saad S.
- Saenz A.
- Sakka P.
- Sala G.
- Salani F.
- Saltvedt I.
- Salvadori N.
- Sanabria A.
- Sanabria Ă.
- Sanchez Abalos M.
- Sanchez del Valle DĂaz R.
- Sanchez-Garcia F.
- Sastre I.
- Satizabal C.L.
- Scamosci M.
- Scarmeas N.
- Scarpini E.
- Schellenberg G.D.
- Scheltens P.
- Scherbaum N.
- Scherer M.
- Schmid M.
- Schneider A.
- Schott J.M.
- Seidu N.M.
- SelbĂŠk G.
- Seripa D.
- Serpente M.
- Serrano-Rios M.
- Serrano-RĂos M.
- Seshadri S.
- Sevillano Z.
- Sims R.
- Skoog I.
- Skrobot O.A.
- Sleegers K.
- Smith A.D.
- Snowden J.
- Soininen H.
- Solfrizzi V.
- Solis P.
- Solomon A.
- Sommerville E.W.
- Sorbi S.
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Spallazzi M.
- Spalletta G.
- Spottke A.
- Squassina A.
- Strandberg T.
- Stringa N.
- SĂĄez M. E.
- SĂĄez M.E.
- SĂĄnchez-Juan P.
- SĂĄnchez-Juan P.
- SĂĄnchez-Valle R.
- Tagliavini F.
- Takalo M.
- Tankard R.M.
- Tegos T.
- Teipel S.
- Tesi N.
- Thomassen J.Q.
- Thonberg H.
- Todd S.
- Traykov L.
- Tremolizzo L.
- Tsolaki M.
- Tuomilehto J.
- TybjĂŠrg-Hansen A.
- TĂĄrraga L.
- TĂĄrraga L.
- Ullgren A.
- Vacca A.
- Valero S.
- Valero S.
- Valero S.
- Van Broeckhoven C.
- van der Flier W.M.
- van der Lee S.J.
- Van Dongen J.
- van Duijn C.M.
- van Schoor N.M.
- Vandenberghe R.
- Vardy E.R.L.C.
- Vargas L.
- Vicente M.P.
- Vidal J-S
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang J.
- Vyhnalek M.
- Wagner M.
- Wallon D.
- Wang L-S
- Weber H.
- Weinhold L.
- Wilcock G.
- Williams J.
- Wiltfang J.
- Windle G.
- Woods R.
- Yang Q.
- Yannakoulia M.
- Zetterberg H.
- Zettergren A.
- Zoia C.P.
- Zulaica M.
- Ălvarez I.
- Ălvarez V.
- Ălvarez V.
- Publication venue
- 'Nature Research Society'
- Publication date
- 01/01/2021
- Field of study
Genetic discoveries of Alzheimerâs disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery nâ=â409,435 and validation size nâ=â58,190). Here, we add six variants associated with Alzheimerâs disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimerâs disease patients in APOE É4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimerâs disease
Dark Matter: Direct Detection
- Author
- A. Alessandrello
- A. Alessandrello
- A. Alessandrello
- A. Benoit
- A. Bottino
- A. Bottino
- A. Cleland
- A. Hitachi
- A.G. Riess
- A.K. Drukier
- A.K. Drukier
- A.O. Gattone
- B. Cabrera
- B. Young
- B.W. Lee
- C. Alcock
- C. Alcock
- C. Alcock
- C. Bobin
- C. Hagmann
- C. Hagmann
- D. Abriola
- D. Drain
- D. LHĂŽte
- D. Reusser
- D. Spergel
- D.I. Bradley
- D.N. Schramm
- D.O. Caldwell
- D.P. Snowden-Ifft
- D.P. Snowden-Ifft
- D.P. Snowden-Ifft
- D.P. Snowden-Ifft
- E. Aubourg
- E. Carretta
- E. Fiorini
- E.A. Baltz
- F. Hasenbalg
- F. Zwicky
- F.T. Avignone
- G. Alimonti
- G. Chardin
- G. Gerbier
- G. Hinshaw
- G. Raffelt
- H. Ejiri
- H. Kraus
- H. Schlattl
- H. Wang
- I. Zlatev
- I.S. Altarev
- J. Ellis
- J. Preskill
- J. Rich
- J. Silk
- J.E. Kim
- J.E. Kim
- J.I. Collar
- J.I. Collar
- J.J. Quenby
- K. Zioutas
- K.D. Irwin
- K.D. Irwin
- K.N. Buckland
- L. Baudis
- L. Baudis
- L. Baudis
- L.A. Hamel
- M. Beck
- M. Bravin
- M. Dine
- M. Kamionkowski
- M. Milgrom
- M. Minowa
- M. Mori
- M. MĂŒck
- M. Tada
- M.J. Lehner
- M.S. Turner
- M.W. Goodman
- N. Booth
- N.E. Booth
- N.J.C. Spooner
- N.J.T. Smith
- N.J.T. Smith
- N.J.T. Smith
- O. Suvorova
- P. Astone
- P. Belli
- P. Bernardis de
- P. Meunier
- P. Sikivie
- P. Sikivie
- P.F. Smith
- P.F. Smith
- R. Abusaidi
- R. Bernabei
- R. Bernabei
- R. Bernabei
- R. Bernabei
- R. Hazama
- R. Ibata
- R. Ibata
- R. Peccei
- R.C. Bay
- R.E. Lanou
- R.J. Schoelkopf
- R.M. Clarke
- R.P. Welty
- R.W. Schnee
- S. Burles
- S. Cebrian
- S. DePanfilis
- S. Labini
- S. Marnieros
- S. Perlmutter
- S.M. Faber
- S.P. Ahlen
- S.R. Bandler
- T. Damour
- T. Lasserre
- T. Shutt
- T.A. Fulton
- T.M. Tripp
- V.A. Kudryavtsev
- W. Ootani
- W.U. Wuensch
- Y. Fukuda
- Y. Ramachers
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pathogenesis of Bovine alphaherpesvirus 2 in calves following different routes of inoculation
- Author
- Alice F.J.
- Almeida S.R.
- Borchers K.
- Bruna P. Amaral
- Campos F.S.
- Castrucci G.
- Castrucci G.
- Castrucci G.
- Castrucci G.
- Castrucci G.
- Castrucci G.
- Castrucci G.
- Dardiri A.H.
- Dezengrini R.
- Eduardo F. Flores
- Ehlers B.
- Field H.J.
- Gibbs E.P
- Gibbs E.P.
- Imai K.
- Johnston W.S.
- José C. Jardim
- Juliana F. Cargnelutti
- Kanekiyo M.
- Kemp R.
- Kollias C.M.
- Letchworth G.J.
- Letchworth G.J.
- Letchworth G.J.
- Letchworth G.J.
- Martin W.B
- Martin W.B.
- Martin W.B.
- Mathias Martins
- Plowright W.
- Probert M.
- Rudi Weiblen
- Rweyemamu M.M.
- Scott F.M.
- Smee D.F.
- Snowden B.W.
- Sterz H.
- Torres F.D.
- Torres F.D.
- Torres F.D.
- Turner A.J.
- Turner A.J.
- Verma I.M.
- Watanabe T.T.N.
- Weaver L.D.
- Westbury H.A.
- Woods J.A.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Aluminium tolerance in barley (Hordeum vulgare L.): physiological mechanisms, genetics and screening methods
- Author
- A. Aniol
- A. Aniol
- A. Aniol
- A. Aniol
- A. Haug
- A.B. Xu
- A.R. Hede
- B. Ezaki
- B. Ezaki
- B. Ezaki
- B. Read
- B.D. Nguyen
- B.F. Borie
- B.F. Carver
- B.F. Carver
- B.F. Carver
- B.J. Read
- B.J. Scott
- B.W. Bache
- C. Caldwell
- C. Mao
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Foy
- C.D. Li
- C.E.O. Camargo
- C.H. Williams
- C.R. Riede
- D.A. Reid
- D.A. Reid
- D.A. Reid
- D.A. Watt
- D.F. Garvin
- D.J. Brady
- D.P. Moore
- D.R. Parker
- D.T. Clarkson
- D.T. Clarkson
- E. Delhaize
- E. Delhaize
- E. Delhaize
- E. Delhaize
- E. Minella
- E. Minella
- E. Polle
- E.M. Lisitsyn
- F. Gallardo
- F. Hamel
- F.C.P. Blamey
- F.C.P. Blamey
- F.C.P. Blamey
- F.E. Ninamango-CĂĄrdenas
- F.J. Gallego
- F.J. Gallego
- F.M. Gauthier
- G. Miftahudin
- G. Simons
- G.J. Taylor
- G.J. Taylor
- G.J. Taylor
- Guo-ping Zhang
- H. Matsumoto
- H. Matsumoto
- H. Raman
- H. Raman
- H. Raman
- H. Takagi
- H.R. UexkĂŒll von
- Harsh Raman
- IRRI
- J. Becker
- J.A. Duke
- J.A. Fisher
- J.D. Ownby
- J.F. Ma
- J.F. Ma
- J.F. Ma
- J.F. Ma
- J.L. Yang
- J.M. Fuente de la
- J.P. Wang
- Jun-ping Wang
- K. Arumuganathan
- K. Maltais
- K. Ohki
- K.C. Snowden
- K.D. Richards
- K.E. Hammond
- K.M. Cocker
- L. Bona
- L. Bona
- L. Tamas
- L.M. Mugwira
- L.M. Shuman
- L.V. Kochian
- L.V. Kochian
- L.V. Kochian
- M. Henderson
- M. Hossain
- M. Loper
- M. Matos
- M. Rincon
- M. Whitten
- M.A.R. Milla
- M.A.R. Milla
- M.B. Stange
- M.C. Luo
- M.L. Lima de
- M.M. Millard
- M.Y. Zhu
- Mei-xue Zhou
- N.A. Ruiz-Torres
- N.C. Carpita
- Neville Mendham
- O. StĂžlen
- O.A. Hoekenga
- O.A. Hoekenga
- P. Wu
- P.R. Ryan
- P.S. Kidd
- R. BĂŒschges
- R. Cruz-Ortega
- R. Little
- R.B. Clark
- R.J. Bennet
- R.L. Aitken
- R.R. Furlani
- S. Ball
- S. Ishikawa
- S. Lindberg
- S. Lindberg
- S.C. Miyasaka
- S.J. Zheng
- S.M. Alam
- S.M. Alam
- S.T. Sibov
- T. Sasaki
- T. Wagatsuma
- T. Wagatsuma
- T.B. Kinraide
- T.B. Kinraide
- T.Y.Y. Sasaki
- V. Puthota
- V.T. Nguyen
- V.T. Nguyen
- W. Bergmann
- W.J. Horst
- X.F. Li
- X.M. Hu
- Y. Tang
- Y.C. Liang
- Z. Rengel
- Z.Q. Zhao
- Publication venue
- Zhejiang University Press
- Publication date
- 14/09/2006
- Field of study
Aluminium (Al) toxicity is one of the major limiting factors for barley production on acid soils. It inhibits root cell division and elongation, thus reducing water and nutrient uptake, consequently resulting in poor plant growth and yield. Plants tolerate Al either through external resistance mechanisms, by which Al is excluded from plant tissues or internal tolerance mechanisms, conferring the ability of plants to tolerate Al ion in the plant symplasm where Al that has permeated the plasmalemma is sequestered or converted into an innocuous form. Barley is considered to be most sensitive to Al toxicity among cereal species. Al tolerance in barley has been assessed by several methods, such as nutrient solution culture, soil bioassay and field screening. Genetic and molecular mapping research has shown that Al tolerance in barley is controlled by a single locus which is located on chromosome 4H. Molecular markers linked with Al tolerance loci have been identified and validated in a range of diverse populations. This paper reviews the (1) screening methods for evaluating Al tolerance, (2) genetics and (3) mechanisms underlying Al tolerance in barley
Common variants in Alzheimerâs disease and risk stratification by polygenic risk scores
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Genetic discoveries of Alzheimerâs disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimerâs disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimerâs disease patients in APOE É4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimerâs disease. © 2021, The Author(s)
Common variants in Alzheimerâs disease and risk stratification by polygenic risk scores
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Genetic discoveries of Alzheimerâs disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimerâs disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimerâs disease patients in APOE É4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimerâs disease. © 2021, The Author(s)
Literatur
- Author
- Abfassung STROBEL A.
- Abfassung STROBEL A.
- Abfassung STROBEL A.
- Aedile GILL D.W.J.
- Aedile GILL D.W.J.
- Aedile GILL D.W.J.
- Aedile GILL D.W.J.
- Aedile GILL D.W.J.
- Aedile GILL D.W.J.
- Agricola TACITUS P. CORNELIUS
- Allgemein FISCHER TH.
- ALPERS
- ALPERS
- Ancient Jewish Terrorists HORSLEY R.A.
- Ancient Jewish Terrorists HORSLEY R.A.
- Ancient Jewish Terrorists HORSLEY R.A.
- Ancient Jewish Terrorists HORSLEY R.A.
- ANDERSSON
- ANRW
- Art ALZINGER W.
- Art ANNEN F.
- Art BELLEN H.
- Art BERGER K.
- Art BIEBERSTEIN K.
- Art BOER W. DEN
- Art BRUCE F.F.
- Art BRUCE F.F.
- Art BRUCE F.F.
- Art BRUCE F.F.
- Art BĂR K.
- Art DALY G.
- Art DE LIBERO L.
- Art DEISSMANN-MERTEN M.
- Art DELLING G.
- Art DELLING G.
- Art DEUBLER A.
- Art DIETRICH A.
- Art DILLMANN R.
- Art DOUGLAS J.D.
- Art DUBIELZIG U.
- Art DĂRRIE H.
- Art ERNST M.
- Art ETTL C.
- Art FAY S.C.A.
- Art FAY S.C.A.
- Art FITZMYER J.A.
- Art FITZMYER J.A.
- Art FOERSTER W.
- Art FOERSTER W.
- Art FOHRER G.
- Art FORD J.A.
- Art FRANKE TH.
- Art FRATEANTONIO CHR.
- Art FRENSCHKOWSKI M.
- Art FRENSCHKOWSKI M.
- Art FRY V.R.L.
- Art FUCHS J.G.
- Art GASQUE W.W.
- Art GAVENTA B.R.
- Art GĂRTNER H.
- Art HARRIS B.F.
- Art HASITSCHKA M.
- Art HAUG W.
- Art HEICHELHEIM F.M.
- Art HEINRICHS J.
- Art HELCK W.
- Art HELCK W.
- Art HELCK W.
- Art HERBST H.
- Art HERBST H.
- Art HERION G.A.
- Art HERMANN A.
- Art HOFRICHTER P.
- Art HOLZHAUSEN J.
- Art HOPPE R.
- Art HOPPE R.
- Art HORSLEY G.H.R.
- Art HĂUPTLI B.W.
- Art KOCH K.
- Art KOLLWITZ J.
- Art KOWALSKI B.
- Art KREUZER S.
- Art KUBITSCHEK W.
- Art KUHN K.G.
- Art KUHOFF W.
- Art KĂRY TH.
- Art LANG F.
- Art LAST H.
- Art LAUFFER S.
- Art LE BONNIEC H.
- Art LEISTEN TH.
- Art LEVINE L.J.
- Art LIMBECK M.
- Art LINTOTT A.W.
- Art LINTOTT A.W.
- Art LIPPOLD A.
- Art LOGAN A.H.B.
- Art LOHWASSER A.
- Art MARTIN J.
- Art MARTIN T.W.
- Art MAYER-MALY TH.
- Art MAYER-MALY TH.
- Art MEDICUS D.
- Art MEIER CHR.
- Art MEIER CHR.
- Art MERKEL H.
- Art MICHAELIS W.
- Art MICHEL O.
- Art MIKAT P.
- Art MILNS R.D.
- Art MITTMANN S.
- Art MĂLLE H.
- Art MĂLLE H.
- Art MĂLLER P.-G.
- Art NAJOCK D.
- Art NEEF H.-D.
- Art NETZER E.
- Art NETZER E.
- Art NEUMANN A.R.
- Art NEUMANN A.R.
- Art NEUMANN A.R.
- Art NEUMANN A.R.
- Art NEUMANN A.R.
- Art NIEDERWIMMER K.
- Art OLSHAUSEN E.
- Art ONKEN B.
- Art OPELT I.
- Art PAHLITZSCH J.
- Art PALZKILL E.
- Art PAPATHANASSIOU V.
- Art PAULIEN J.
- Art PAULIEN J.
- Art PETZKE G.
- Art PEUCKERT R.
- Art PFLAUM H.-G.
- Art PĂHLMANN W.
- Art RABER F.
- Art RITTER K.A.
- Art RĂGDI G.
- Art SCHALLER B.
- Art SCHALLER B.
- Art SCHAVAN A.
- Art SCHELKLE K.H.
- Art SCHENK W.
- Art SCHENK W.
- Art SCHMIDT G.
- Art SCHMITT CHR.
- Art SCHMITT CHR.
- Art SCHNEIDER C.
- Art SCHNEIDER H.
- Art SCHNEIDER H.
- Art SCHNEIDER J.
- Art SCHNEIDER J.
- Art SCHNEIDER R.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHNEIDER S.
- Art SCHOLTISSEK K.
- Art SCHRAGE W.
- Art SCHRAGE W.
- Art SCHRENK G.
- Art SCHRENK G.
- Art SCHROT G.
- Art SCHULZ S.
- Art SCHWINDT R.
- Art SCHWINDT R.
- Art SCHWINDT R.
- Art SEELIGER H.R.
- Art SEIBERT J.
- Art SENFF R.
- Art SETZER C.J.
- Art SETZER C.J.
- Art SIEGERT F.
- Art SIEVERS J.
- Art SIMON L.
- Art SIMON L.
- Art SMITH R.H.
- Art STAUDINGER F.
- Art STEINBAUER D.
- Art STETTBERGER H.
- Art STETTBERGER H.
- Art STETTBERGER H.
- Art STIMPFLE A.
- Art STIMPFLE A.
- Art STIMPFLE A.
- Art STIMPFLE A.
- Art STIMPFLE A.
- Art STOOPS JR. R.F.
- Art STRAUB J.
- Art STRAUB J.
- Art STROTHMANN J.
- Art STROTHMANN M.
- Art SUCHLA B.R.
- Art SUNCKEL J.
- Art THIEDE C.P.
- Art THIEDE C.P.
- Art THIEDE C.P.
- Art THIEDE C.P.
- Art THRAEDE K.
- Art TILL R.
- Art TOOLE R.F.
- Art TORAL-NIEHOFF I.
- Art UNTERGASSMAIR F.G.
- Art WOLTER M.
- Art ZINTZEN C.
- Art ZMIJEWSKI J.
- Art ZWICKEL W.
- Asia TREBILCO P.
- Aspekte
- Auf SĂNGER D.
- Augustus FUHRMANN M.
- BARNETT
- Bd.
- Bd.
- BEALE
- Bibelauslegung Feministische
- BICKERMANN
- BIEBERSTEIN
- BIEBERSTEIN
- BIELINSKI K.
- BLANK
- BLANK
- Blasphemy BOCK D.L.
- BLEICKEN
- BLUE
- BOND
- BONNER C.
- BOTERMANN
- BOVON
- BOWERSOCK
- BRANDENBURGER
- BRAUND
- BRAUND
- BRAUND
- BRAUND
- BRAUND
- BRAUND
- BRAUND
- BRAUND
- BRAUND
- BRIGGS
- BROER
- BROER
- BROER
- BROER
- BROOTEN
- BROWN
- BROX
- BĂSEN
- BĂTTEL
- Caesar's SMITH R.
- Caligula BARRETT A.
- Caligula QUIDDE L.
- Cambridge
- Century Setting Its First
- Chamberlain's Journey MARTIN C.J., A
- Chief Priests MASON S.
- Christus BĂCHER O.
- Christus BĂCHER O.
- Cyprus NOBBS A.
- Damaskus FREYBERGER K.S.
- Das Markusevangelium ECKEY W.
- Das Markusevangelium ECKEY W.
- Das PESCH R.
- DAVIES
- DE JONGE
- DEININGER
- DEISSMANN-MERTEN
- DEMANDT
- DEMOUGIN
- den Verhaltens LAMNEK S.
- der Apostelgeschichte SCHREIBER S.
- Der Bandit SHAW B.D.
- Der Bandit SHAW B.D.
- Der Bandit SHAW B.D.
- Der BECKER J.
- Der DESSAU H.
- Der Freigelassene ANDREAU J.
- Der Freigelassene ANDREAU J.
- Der LĂSCH S.
- Der LĂSCH S.
- Der MĂLLER M.
- Der Philipperbrief GNILKA J.
- Der THEISSEN G.
- Der THEISSEN G.
- des Neuen Testaments Die Welt
- DIBELIUS
- Die BLINZLER J.
- Die BLINZLER J.
- Die FĂLDY G.
- Die IturÀer SCHOTTROFF W.
- Die MERKEL H.
- Die MERKEL J.
- Die SCHNEIDER G.
- Die SELINGER R.
- Die SUETON
- Die SĂDING TH.
- Die TRILLING W.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die VOLKMANN H.
- Die ZERWICK M.
- DIETZFELBINGER
- Domitian SOUTHERN P.
- DORMEYER
- DORMEYER
- DORNSEIFF
- DOWNING
- DSCHULNIGG
- DSCHULNIGG
- DSCHULNIGG
- Early Christian Literature KOESTER H.
- Early Christian Literature KOESTER H.
- ELVERS
- ENDRUWEIT
- Ephesians ARNOLD C.E.
- Epigrams MARTIAL
- Epigrams MARTIAL
- Epigrams MARTIAL
- ERNST
- ERNST
- ERNST
- ERNST
- FANDER
- FASCHER
- FEE
- FELDMEIER
- FIENSY
- FITZMYER
- FITZMYER
- FLEISCHER
- FLUSSER
- FLUSSER
- FLUSSER
- FLUSSER
- FREUDENBERGER
- FRICKE
- FS G.
- Galilee BLACK M.
- Galilee FREYNE S.
- Galilee FREYNE S.
- Galilee FREYNE S.
- GALSTERER
- GARNSEY
- GARNSEY
- Gebt dem Kaiser STENGER W.
- GEIGER
- GELSDORF
- GESCHE
- Geschichtsschreibung Zur
- Geschichtsschreibung Zur
- Geschichtsschreibung Zur
- Geschichtsschreibung Zur
- Geschichtsschreibung Zur
- GIBLIN CH.
- GIESEN
- GieĂen
- Glaube HORN F.W.
- Grassl
- GroĂe Griechen PLUTARCH
- Göttingen
- HABES
- HANSON
- HASTINGS
- HENGEL
- HENGEL
- HENGEL
- Herod FRANCE R.T.
- HERRMANN-OTTO
- HERRMANN-OTTO
- HERZER
- HEUSLER
- Historia Romana VELLEIUS PATERCULUS
- HOFIUS
- HOFIUS
- HOFIUS
- HĂFER
- HĂ€upter ULRICHSEN J.H.
- HĂLSCHER
- HĂRER
- HĂSSLER FIORENZA
- HĂTZ
- Innsbruck
- Its First Century Setting Acts
- Jesus STAUFFER E.
- Jesus vor Herodes MĂLLER K.
- Jesus vor Herodes MĂLLER K.
- Jesus vor Herodes MĂLLER K.
- Jesus vor Herodes MĂLLER K.
- Jesus vor Herodes MĂLLER K.
- Jesus vor Herodes MĂLLER K.
- Jesus vor Pilatus DIEBOLD-SCHEUERMANN C.
- Jesus ZELLER D.
- Johannes der TĂ€ufer MĂLLER U.B.
- Julia Berenice MACURDY G.H.
- Kaiser Augustus MĂŒnchen
- Kaisernamen DIECKMANN H.
- Kaisernamen DIECKMANN H.
- Keuchen
- KOCH
- KOCH
- KOKKINOS
- KOPP
- KRAFT
- KRAUS
- KRIEGER
- KRIEGER
- KRIEGER
- KRIEGER
- KRIEGER
- KRIEGER
- Kritik
- KUHN
- KUHN
- KUHN
- KUHNEN
- Köln
- König Herodes SCHALIT A.
- König Herodes SCHALIT A.
- KĂCHLER M.
- KĂCHLER M.
- KĂGLER
- La Candace TRIGGER B.G.
- LABAHN
- LANG
- LEMONON
- LEMONON
- LEROY
- LEVICK
- LINZ
- Literatur
- Literatur
- London
- Lukasevangelium
- Luke-Acts BRENT A.
- LĂNDER
- LĂGASSE
- LĂNING
- LĂDEMANN
- LĂMACHER
- LĂMACHER
- LĂMACHER
- LĂMACHER
- M.
- M.
- MACKENDRICK
- MAGALL
- Magus Simon
- MALINA
- MALINA
- MALINA
- MALINA
- Marginal MEIER J.P., A
- MARTIN
- MASTIN
- MATERA
- MatthĂ€us MĂLLE H.
- MAYR
- MCRAY
- MEEKS
- MEEKS
- MEISER
- MEISTER
- MELITO OF
- MELZER-KELLER
- MERKEL
- MERKLEIN
- MESHORER
- METZNER
- METZNER
- METZNER
- MEYER
- MILLARD
- Mir zu FĂŒĂen HĂFER H.
- MITCHELL
- MITCHELL
- MOEHRING
- MULLER
- MĂŒnchen
- Nachfolger Herodes
- Nachfolger Herodes
- Naherwartungen PESCH R.
- Naherwartungen PESCH R.
- Naherwartungen PESCH R.
- NEESEN
- NEGEV
- Nero HOLLAND R.
- Nero MALITZ J.
- Neue Testament SCHNELLE U.
- NEUSNER
- NEUSNER
- New Theophilus MARX W.G., A
- Nicodemus SYLVA D.D.
- NIEMAND
- NOCK
- NOETHLICHS
- NOETHLICHS
- OBERLINNER
- Octavius MINUCIUS FELIX
- OLLROG
- OMERZU
- OMERZU
- OSTER
- PASSOW
- Paul STRELAN R.
- Paul TAYLOR J., St.
- Paul TAYLOR J., St.
- Paul's Corinth CONNOR J., St.
- Paulus Sergius
- Pax Romana BOWLEY J.E.
- Personale PublizitÀtsdynamik DETERMEYER R.
- Pethor YAURE L.
- PETRACCA
- PETZL
- Pharisees SALDARINI A.J.
- Philipper
- Philippi BORMANN L.
- Philippi PILHOFER P.
- Philippus DINKLER E.
- Philosophische Schriften SENECA L.A.
- Pilatus
- Pilatus Pontius
- PLINIUS D.
- Pontius Pilatus DIEBNER B.J.
- Prominenz PETERS B.
- Publius Sulpicius Quirinius LAWRENCE J.
- Rapids
- Roman Cyprus MITFORD T.B.
- Roman Woman MARSHALL A.J.
- Romfahrt des Paulus SUHL A.
- Romfahrt des Paulus SUHL A.
- Römische Kaiser SCHINDLER W.
- Römischer Staat MEYER E.
- Römischer Staat MEYER E.
- Römisches Staatsrecht MOMMSEN TH.
- Römisches Staatsrecht MOMMSEN TH.
- Römisches Staatsrecht MOMMSEN TH.
- Römisches Staatsrecht MOMMSEN TH.
- Römisches Staatsrecht MOMMSEN TH.
- Römisches Strafrecht MIGLIETTA M.
- RĂCK
- SAFRAI
- SASSE
- SAUTER
- SCARRE
- SCHEIDGEN
- SCHENKE
- SCHIEMANN
- SCHMIDL
- SCHMIDL
- SCHMITHALS
- SCHMITHALS
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER
- SCHNEIDER W.
- SCHOTTROFF
- SCHOTTROFF
- SCHOTTROFF
- SCHOTTROFF
- SCHOTTROFF
- SCHRECKENBERG
- Schriften I
- SCHULLER
- SCHULTE
- SCHWARTZ D.R.
- SCHWARTZ D.R.
- SCHWARTZ D.R.
- SCHWARTZ D.R.
- SCHWARTZ D.R.
- SCOTT
- SCRAMUZZA
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- Senecas BRINGMANN K.
- SENIOR
- Setting First Century
- SHERWIN-WHITE
- Signs SCHERRER S.J.
- Simonianer Simon
- Simonianer Simon
- SNOWDEN
- Sonderausgabe MĂŒnchen
- SORDI
- Sozialgeschichte Römische
- SPEIGL
- SPENCER
- SPERBER
- SPEYER
- SPEYER
- STAATS
- STAMBAUGH
- STEGEMANN
- STIBBE
- STIMPFLE
- STOLLE
- STRABO
- STRECKER
- STREETER
- STROCKA
- STUHLMACHER
- STUHLMACHER
- STUHLMACHER
- Stuttgart
- SULLIVAN
- Sup
- Syria TRACEY R.
- TAJRA
- TERTULLIAN
- The Census BRINDLE W.
- The HART H.
- The HEMER C.J.
- The HORBURY W.
- The Jewish MALBON E.S.
- The Lucan Censuses PEARSON B.W.R.
- The Luke Passion HARRINGTON J.M.
- The MCGING B.C.
- The MCGING B.C.
- The METZGER B.M.
- The New Testament ACHTEMEIER P.J.
- The Roman Concept MACMULLEN R.
- The STRANGE W.A.
- The TANNEHILL R.C.
- The Trial WALASKAY P.W.
- The Universal Famine GAPP K.S.
- THEISSEN
- Theophilos SCHROETER-WITTKE H.
- Theophilus ANDERSON R.H.
- THIESSEN
- THOMAS
- THOMPSON
- Tiberius YAVETZ Z.
- Titulus Crucis GEIGER J.
- Titus STAHLMANN I.
- Tradition SOARDS M.L.
- TRAUGOTT
- True Jew SUGGIT J.N.
- Tugend FĂRST A.
- Twice Neokoros FRIESEN S.
- Twice Neokoros FRIESEN S.
- Typical KRAEMER R.S.
- TĂVER
- TĂŒbingen
- UNGER
- UNNIK W.C.
- URBAN
- Urchristentum
- URNER
- v.Chr Tode
- VANDERKAM
- Vergessene JĂŒngerinnen VENETZ H.-J.
- Vergessene JĂŒngerinnen VENETZ H.-J.
- VERMES
- VITTINGHOFF FR.
- VITTINGHOFF FR.
- VOGT
- VOLKMANN H.
- War der Apostel STEGEMANN W.
- War der Apostel STEGEMANN W.
- War der Apostel STEGEMANN W.
- Wege
- Weimar
- Why MORRIS R.L.B.
- Widmung des Iukanischen VĂGTLE A.
- Wundergeschichten Urchristliche
- Wundergeschichten Urchristliche
- Wundergeschichten Urchristliche
- Wundergeschichten Urchristliche
- WUNT
- ZANGENBERG
- Zeit Àtrepublikanischer
- Zeloten Die
- Zum TĂHLIN G.
- ZUNTZ
- Ăkonomie der Aufmerksamkeit FRANCK G.
- ömische Provinzialzensus BRAUNERT H.
- ömische Staat MOLTHAGEN J.
- ömischen LAMPE P.
- ömischen LAMPE P.
- ömischen LOHSE E.
- ömischen LOHSE E.
- ömischen LOHSE E.
- ömischer Zeit JĂŒdische Geschichte
- östlichen Mittelmeerraum
- ĂŒbers SIBYLLINEN
- ĂŒbers SIBYLLINEN
- ĂŒbers SYRISCHE BARUCH-APOKALYPSE
- ĂŒbers WEISHEIT SALOMOS
- ĂŒdischer ömischer
- ĂŒr Antike Jahrbuch
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study