Biological Evaluation of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives as Anti-agents

Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. A series of new nimesulide analogs were evaluated with cell proliferation assay based on a non-small lung cancer cell line H292. The results showed that several derivatives were very active to against H292 cell growth with IC50s of sub nano mole. These results suggest the possibility of using these nimesulide derivatives as chemo preventive agents.https://engagedscholarship.csuohio.edu/u_poster_2012/1036/thumbnail.jp

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Performance Modelling of Message-Oriented Middleware with Priority Queues

Message-Oriented Middleware (MOM) with priority queues reduces the latency of critical events. In general, MOM uses a FIFO queuing methodology. But, different application scenarios require certain critical events with higher priority to be served earlier over low-priority events, so that the subscriber of the event consumes the high-priority event with less delay. In the context of the Palladio Component Model (PCM), MOM-based systems have been modelled considering message queue length and latency as metrics for performance prediction and simulation. However, the approaches did not consider modelling MOM with priority queues and their impact on performance. We will first, discuss the existing approaches in PCM which support performance prediction for MOM-based systems and then propose how they can be extended to support performance predictions for MOM with priority queuing. We will then conclude which approach is best suited to extend by assessing their capabilities to predict performance metrics relevant for priority queuing, especially the delay of individual events at the subscriber end

Initial conditions from the shadowed Glauber model

The two component Monte-Carlo Glauber model predicts a knee-like structure in the centrality dependence of elliptic flow $v_2$ in Uranium+Uranium collisions at $\sqrt{s_{NN}}=193$ GeV. It also produces a strong anti-correlation between $v_2$ and $dN_{ch}/dy$ in the case of top ZDC events. However, none of these features have been observed in data. We address these discrepancies by including the effect of nucleon shadowing to the two component Monte-Carlo Glauber model. Apart from addressing successfully the above issues, we find that the nucleon shadow suppresses the event by event fluctuation of various quantities, e.g. $\varepsilon_2$ which is in accordance with expectation from the dynamical models of initial condition based on gluon saturation physics.Comment: version accepted for publication in Physics Letters

Respiratory health of the small scale dairy workers of urban Bhubaneswar, Odisha

Background: Human in close inhabitation with the cattle due to unventilated or inadequately ventilated establishments or inadequate living space, is always at a risk of sustaining infection from the cattle through different modes of disease transmission. This study hints at the increased incidences in respiratory infections among dairy workers in unorganized and small scale dairy farms due to amendable unhygienic practices. Methods: This survey was part of a larger study, conducted after ethics approval. Number of households involved in dairy work surveyed were 60. From every house, two members actively involved in dairy work were chosen and total respondents were 120. The study tool was a semi structured, mixed questionnaire. Results: 67.5% dairy workers self-reported occurrence of respiratory symptoms which included the complaints like cough,breathing difficulty on exertion. None of the dairy workers were vaccinated against any milk borne disease.Conclusion: The housing, civic amenities accessed by them and their awareness are probably the main reasons for wide variety of self perpetuated practices and deviations of standard requirement.Use of protective gear (gloves,caps,masks) should be strictly emphasized and popularized

Hygiene practices and awareness regarding Milk borne diseases (MBD) among dairy workers in unorganized urban settings of Bhubaneswar, Odisha, India

Background: Dairy work is thought to be predominantly a rural occupation. However, due to preferences we see a lot of urban residents consume fresh milk and hence, few people even in the urban areas take up cattle rearing as a cost effective profession. In the midst of much talked re-emerging diseases, caused by close habitation of animals and man, it would be very relevant to see living conditions of these populations and their hygiene practices in a space compromised scenario. In urban settings, they stay in close proximity and due to socioeconomic conditions, dairy workers in do not have appropriate amenities to tend on the cattle,clean or even scope for proper waste disposal. This in nutshell, leads to a disease enabling environment and the study aims at reviewing these living conditions. Besides, an assessment of health conditions of the dairy workers, their awareness regarding the milk borne diseases(MBD) was done. The findings helped generate recommendations for improvement of the profession and ultimately the quality of the milk. Objectives:1) Assess the hygiene practices during the stages of milk collection, storage and transport of milk among the sampled dairy workers from urban unorganized settings of Bhubaneswar. 2) Assess awareness of these workers regarding milk borne diseases. Methodology: This cross?sectional survey was part of a larger study and was conducted in unorganized sector of dairy workers in Bhubaneswar. 60 dairy households were surveyed and from each household, 2 members actively involved in dairy work were selected.The study tool was a semi structured, mixed questionnaire. The questionnaire had 3 sections; A was regarding household information(General sociodemographic details and Housing conditions for 60 HHs); B was to elicit the hygiene status of dairy workers(n=120) during each step of their work, their milk handling details during milk collection, storage and transportation; C had questions to assess the awareness of dairy worker regarding MBD. Results: Hygiene practices were very dismal at all points like milking,storage and transportation. Only 5.0% dairy households practised cleaning udder twice- prior to and after milking. Only 35% households kept the milk storage containers covered. 44.2% workers agreed that “MBD” is a community health problem. On general examination, pallor and icterus was found among workers. This strongly brings out that this group not only have the potential to be infected by zoonotic diseases, but can also transmit it to through the milk they are selling. A felt need is assessed for these workers in terms of creating standards of hygiene practices of cattle and milk handling and also impart them training on improving their occupational practices

True broad ligament fibroid mimicking ovarian mass in a postmenopausal woman

Fibroids are benign smooth muscle tumors. Large fibroids are known to arise from the uterus, but occasionally from the broad ligament.  Here, we report a case of true broad ligament fibroid which is rare and difficult to diagnose in a 57 year old postmenopausal women with a large mass of 24 weeks size gravid uterus. Patient presented with pain lower abdomen and mass in abdomen with no other co-morbidity. This broad ligament fibroid was mimicking as ovarian tumor on ultrasonography and MRI as left ovary was not visualised separately, thus leading to diagnostic dilemma of ovarian malignancy. Mass resection with total abdominal hysterectomy and bilateral salpingo-oopherectomy was performed. No local or distant metastasis observed, and Histopathology showed true broad ligament fibroid of left side weighing 3.57 kilograms