EFFECT OF CASH MANAGEMENT PRACTICES ON FINANCIAL PERFORMANCE OF SMALL AND MEDIUM ENTERPRISES IN VISAKHAPATNAM AND VIZIANAGARAM DISTRICTS OF ANDHRA PRADESH, INDIA

In any economy, small and medium-sized enterprises (SMEs) play an important role because they are capable of generating employment, fostering GDP growth, embarking on innovation and stimulating other economic activities. The foundation of all developed and emerging nations is said to be this business. The growth of the small and medium-sized enterprises (SME) sector is of vital importance to every country, regardless of its level of development, as this sector has great potential to produce full socio-economic benefits for a country with a minimum level of investment. In their first five years of existence, the number of small and medium-scale enterprises die, and a few numbers of companies go through extinction between the sixth and tenth years. Yet 5 % to 10% of small and medium-sized companies will thrive, prosper, and mature. The cause for this is not simply a lack of money and it could be poor cash management practises. The investigator sought to examine cash management activities of small and medium businesses in this article. A comprehensive analysis with a formal questionnaire from a survey of 360 including 346 small and 14 medium-sized enterprises in the districts of Visakhapatnam and Vizianagaram was used. Article visualizations

Need for Diabetic Screening an a Periodontal Setup

INTRODUCTION: Periodontitis has been proved to be linked deeply with the chronic ailment diabetes. Research data shows that their relationship is direct and bifacial. The prevalence of both these diseases is on the rise but still there is a scarcity of diabetic screening in periodontal set-ups.AIM: To lay emphasis on the need of diabetic screening in a periodontal set-upMATERIAL AND METHODS: An observational, cross-sectional study with an initial sample size of 200 patients was conducted. Periodontitis was evaluated with the CPI index and RBS was measured using a blood glucometer.RESULTS: Significant difference in the periodontitis patients who were aware and unaware of their diabetic status.CONCLUSION: Screening for diabetes in a periodontal clinic is conducive to the creation of awareness and early detection and treatment of such a chronic disease and can help avoid the setting in of related complications by giving the patient a chance to initiate an early intervention

Piperine Attenuates Cigarette Smoke-Induced Oxidative Stress, Lung Inflammation, and Epithelial-Mesenchymal Transition by Modulating the SIRT1/Nrf2 Axis

Piperine (PIP) is a major phytoconstituent in black pepper which is responsible for various pharmacological actions such as anti-inflammatory, antioxidant, and antitumor activity. To investigate the effects and mechanisms of PIP on cigarette smoke (CS)-induced lung pathology using both in-vitro and in-vivo models. BEAS-2B and A549 cells were exposed to CS extract (CSE) for 48 h; BALB/c mice were exposed to CS (9 cigarettes/day, 4 days) to induce features of airway disease. PIP at doses of (0.25, 1.25, and 6.25 µM, in vitro; 1 and 10 mg/kg, in vivo, i.n) and DEX (1 µM, in vitro; 1 mg/kg, in vivo, i.n) were used to assess cytotoxicity, oxidative stress, epithelial-mesenchymal transition (EMT), Sirtuin1 (SIRT1), inflammation-related cellular signaling, and lung function. PIP treatment protects cells from CSE-induced lung epithelial cell death. PIP treatment restores the epithelial marker (p \u3c 0.05) and decreases the mesenchymal, inflammatory markers (p \u3c 0.05) in both in vitro and in vivo models. The PIP treatment improves the altered lung function (p \u3c 0.05) in mice induced by CS exposure. Mechanistically, PIP treatment modulates SIRT1 thereby reducing the inflammatory markers such as IL-1β, IL-6 and TNF-α (p \u3c 0.05) and enhancing the epigenetic marker HDAC2 (p \u3c 0.05) and antioxidant marker Nrf2 (p \u3c 0.05) expressions. Thus, PIP alleviates pulmonary inflammation by modulating the SIRT1-mediated inflammatory cascade, inhibits EMT, and activates Nrf2 signaling