Uncovering Local Trends in Genetic Effects of Multiple Phenotypes via Functional Linear Models

Recent technological advances equipped researchers with capabilities that go beyond traditional genotyping of loci known to be polymorphic in a general population. Genetic sequences of study participants can now be assessed directly. This capability removed technology-driven bias toward scoring predominantly common polymorphisms and let researchers reveal a wealth of rare and sample-specific variants. Although the relative contributions of rare and common polymorphisms to trait variation are being debated, researchers are faced with the need for new statistical tools for simultaneous evaluation of all variants within a region. Several research groups demonstrated flexibility and good statistical power of the functional linear model approach. In this work we extend previous developments to allow inclusion of multiple traits and adjustment for additional covariates. Our functional approach is unique in that it provides a nuanced depiction of effects and interactions for the variables in the model by representing them as curves varying over a genetic region. We demonstrate flexibility and competitive power of our approach by contrasting its performance with commonly used statistical tools and illustrate its potential for discovery and characterization of genetic architecture of complex traits using sequencing data from the Dallas Heart Study

IMPACT OF E – COMMERCE IN SMALL AND MEDIUM SCALE INDUSTRIES IN PUNE

Internet is the place where millions of people start their business to make money. It is the platform which has immense benefits that has helped many people in establishing a successful business over the internet. The most common business which has captured the attention of many business owners these days is e-commerce. E-commerce!!! This is the word that has changed the life of many people who started their own store in the online world. Despite of investing a huge amount on starting a textile industry, manufacturing business or any other, it’s better to pay few hundred & start building an online store website and get a sale at the end of the day. The use of Internet and e-business activities have generated considerable interest in Pune. It’s not hide form anyone now a day’s e-commerce business is one of the best way to access money online and every single year trend of e-commerce is increasing in a rapid way so it is good if you are planning to start an e-commerce business and want the best e-commerce platform. Electronic commerce would be considered as a new idea for small and medium-sized businesses, consumers and governments. Today, electronic commerce is an evolving revolution in electronic trading of the people and involves many benefits of investment and research in the field of electronic commerce to different sectors especially small and medium enterprises. Small and Medium Enterprises (SMEs) may use electronic commerce technologies in a variety of ways, including: to communicate with customers and suppliers, collect market research data, promote goods and services, provide detailed information about products and services, offer after sales support and assistance and support online ordering of goods and services