612 research outputs found
An Examination of the Reasons Leading Individuals to Apostatize from the Seventh-day Adventist Church
This thesis provides an examination of the reasons leading individuals to apostatize from the Seventh-day Adventist Church.https://digitalcommons.andrews.edu/hrsa/1087/thumbnail.jp
Agricultural social networks : an agricultural value chain-based digitalization framework for an inclusive digital economy
DATA AVAILABILITY: Data is unavailable due to privacy or ethical restrictions.Sustainable agriculture is the backbone of food security systems and a driver of human well-being in global economic development (Sustainable Development Goal SDG 3). With the increase in world population and the effects of climate change due to the industrialization of economies, food security systems are under pressure to sustain communities. This situation calls for the implementation of innovative solutions to increase and sustain efficacy from farm to table. Agricultural social networks (ASNs) are central in agriculture value chain (AVC) management and sustainability and consist of a complex network inclusive of interdependent actors such as farmers, distributors, processors, and retailers. Hence, social network structures (SNSs) and practices are a means to contextualize user scenarios in agricultural value chain digitalization and digital solutions development. Therefore, this research aimed to unearth the roles of agricultural social networks in AVC digitalization, enabling an inclusive digital economy. We conducted automated literature content analysis followed
by the application of case studies to develop a conceptual framework for the digitalization of the AVC toward an inclusive digital economy. Furthermore, we propose a transdisciplinary framework that guides the digitalization systematization of the AVC, while articulating resilience principles that aim to attain sustainability. The outcomes of this study offer software developers, agricultural stakeholders, and policymakers a platform to gain an understanding of technological infrastructure capabilities toward sustaining communities through digitalized AVCs.The Carnegie Corporation of New York and the Future Africa Research Leader Fellowship (FAR-LeaF) Programme.https://www.mdpi.com/journal/applsciInformatic
On a new class of tests for the Pareto distribution using Fourier methods
We propose new classes of tests for the Pareto type I distribution using the
empirical characteristic function. These tests are and statistics based
on a characterisation of the Pareto distribution involving the distribution of
the sample minimum. In addition to deriving simple computational forms for the
proposed test statistics, we prove consistency against a wide range of fixed
alternatives. A Monte Carlo study is included in which the newly proposed tests
are shown to produce high powers. These powers include results relating to
fixed alternatives as well as local powers against mixture distributions. The
use of the proposed tests is illustrated using an observed data set
Expanding the epidemiological understanding of hepatitis C in South Africa: Perspectives from a patient cohort in a rural town
Background. The epidemiology of hepatitis C virus (HCV) in the general population of South Africa (SA) is incompletely understood. A high HCV prevalence in key populations is known, but data are limited in terms of a broader understanding of transmission risks in our general population.Objectives. To investigate a patient cohort with HCV infection clustering in a rural SA town, in order to identify possible HCV transmission risks, virological characteristics, phylogenetic data and treatment outcomes.Methods. A cluster of patients with positive HCV serology, previously identified from laboratory records, were contacted by a local district hospital and offered confirmatory testing for HCV viraemia where needed. Those with confirmed HCV RNA were invited to a local hospital visit, where relevant demographic information was recorded, clinical assessment performed and a confidential questionnaire administered. HCV population-based sequencing was performed on HCV NS3/4A, NS5A and NS5B using polymerase chain reaction-specific or M13 universal primers, and sequences were aligned using BioEdit 7.2.5. Phylogenetic trees were constructed. Clinical assessments included liver fibrosis determination with FibroScan (cut-off ≥12.5 kPa = F4). Patients were offered treatment, and sustained virological response (SVR) was confirmed by undetectable HCV RNA at least 12 weeks after the end of treatment.Results. Twenty-one patients, all from the same town, median (interquartile range (IQR)) age 64 (59 - 70) years, 57% female, were evaluated. Of these, 24% (n=5) were HIV co-infected, stable on antiretrovirals. The median (IQR) alanine aminotransferase level was 51 (31 - 89) U/L, with fibrosis distribution including 29% F1, 29% F2, 9% F3 and 33% F4 METAVIR fibrosis. Virologically, two genotypes were observed: 62% (n=13) genotype (GT) 1b and 38% (n=8) GT5a. No patient had ever used injecting drugs, 14% (n=3) had received blood products before 1992, and 9.5% (n=2) had undergone traditional healer-administered scarification. All (n=21) reported attendance at a single primary care clinic in the past, with most (n=20) recalling having received parenteral therapies at the clinic. Phylogenetic analysis of the HCV NS5A and NS5B regions confirmed GT1b and GT5a genotypes and formed two separate clusters within their respective genotypes, suggesting a common source for each genotype infection. Most patients received treatment with sofosbuvir/daclatasvir, 1 was treated with sofosbuvir/velpatasvir, and 1 was re-treated with sofosbuvir/velpatasvir/voxilaprevir. Per protocol SVR was 95%, with the non-SVR patient successfully re-treated.Conclusions. Data from a rural town cluster of patients suggest parenteral medical exposure as the probable common source of hepatitis C transmission risk. The cohort was of older age with a significant number having advanced fibrosis or cirrhosis, suggesting HCV acquisition in the distant past. Using a simplified care approach, treatment outcomes were very good
Rough-and-tumble play as a window on animal communication.
Rough-and-tumble play (RT) is a widespread phenomenon in mammals. Since it involves competition, whereby one
animal attempts to gain advantage over another, RT runs the risk of escalation to serious fighting. Competition is
typically curtailed by some degree of cooperation and different signals help negotiate potential mishaps during RT. This
review provides a framework for such signals, showing that they range along two dimensions: one from signals borrowed
from other functional contexts to those that are unique to play, and the other from purely emotional expressions to
highly cognitive (intentional) constructions. Some animal taxa have exaggerated the emotional and cognitive interplay
aspects of play signals, yielding admixtures of communication that have led to complex forms of RT. This complexity
has been further exaggerated in some lineages by the development of specific novel gestures that can be used to
negotiate playful mood and entice reluctant partners. Play-derived gestures may provide new mechanisms by which
more sophisticated communication forms can evolve. Therefore, RT and playful communication provide a window
into the study of social cognition, emotional regulation and the evolution of communication systems
The new kid on the block: immigrant males win big whereas females pay fitness cost after dispersal
Dispersal is nearly universal; yet, which sex tends to disperse more and their success thereafter depends on the fitness consequences of dispersal. We asked if lifetime fitness differed between residents and immigrants (successful between‐population dispersers) and their offspring using 29 years of monitoring from North American red squirrels (Tamiasciurus hudsonicus) in Canada. Compared to residents, immigrant females had 23% lower lifetime breeding success (LBS), while immigrant males had 29% higher LBS. Male immigration and female residency were favoured. Offspring born to immigrants had 15–43% lower LBS than offspring born to residents. We conclude that immigration benefitted males, but not females, which appeared to be making the best of a bad lot. Our results are in line with male‐biased dispersal being driven by local mate competition and local resource enhancement, while the intergenerational cost to immigration is a new complication in explaining the drivers of sex‐biased dispersal.Our results are in line with male‐biased dispersal being driven by local mate competition and local resource enhancement, while the intergenerational cost to immigration is a new complication in explaining the drivers of sex‐biased dispersal.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154289/1/ele13436-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154289/2/ele13436.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154289/3/ele13436_am.pd
Fulminant hepatitis B virus (HBV) infection in an infant following mother-to-child transmission of an e-minus HBV mutant: Time to relook at HBV prophylaxis in South African infants
The prevalence of hepatitis B virus (HBV) infection in pregnant women is high in South Africa (SA), yet prophylaxis to prevent mother-to-child transmission (MTCT) falls short of international recommendations. We describe a 10-week-old infant who developed fulminant hepatic failure following MTCT. The mother was hepatitis e-antibody positive and had a viral load of only 760 IU/mL. Genetic analysis of virus from mother and infant showed that both had the G1896A mutation in the preC/C gene, which truncates hepatitis e antigen (HBeAg) during translation, causing an HBeAg-negative phenotype. HBeAg attenuates antiviral immune responses, and its absence was probably responsible for the infant’s fulminant hepatitis, due to an uncontrolled immune attack on infected liver cells. Pregnant women are not tested for HBV infection in SA and MTCT rates are unknown. Addition of a birth dose of vaccine, HBV screening of pregnant women and antiviral prophylaxis to positive mothers should be prioritised
Female economic dependence and the morality of promiscuity
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ The Author(s) 2014.In environments in which female economic dependence on a male mate is higher, male parental investment is more essential. In such environments, therefore, both sexes should value paternity certainty more and thus object more to promiscuity (because promiscuity undermines paternity certainty). We tested this theory of anti-promiscuity morality in two studies (N = 656 and N = 4,626) using U.S. samples. In both, we examined whether opposition to promiscuity was higher among people who perceived greater female economic dependence in their social network. In Study 2, we also tested whether economic indicators of female economic dependence (e.g., female income, welfare availability) predicted anti-promiscuity morality at the state level. Results from both studies supported the proposed theory. At the individual level, perceived female economic dependence explained significant variance in anti-promiscuity morality, even after controlling for variance explained by age, sex, religiosity, political conservatism, and the anti-promiscuity views of geographical neighbors. At the state level, median female income was strongly negatively related to anti-promiscuity morality and this relationship was fully mediated by perceived female economic dependence. These results were consistent with the view that anti-promiscuity beliefs may function to promote paternity certainty in circumstances where male parental investment is particularly important
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