Automated Scenario Generation Environment

Report describes IST\u27s investigation into the feasibility of automating the process of planning and scenario generation for large scale (joint level) simulation exercises and development of an architecture for that purpose

A mid-infrared survey of the inner 2 × 1.5 degrees of the Galaxy with Spitzer/IRAC

We present a survey of Spitzer Space Telescope/IRAC observations of the central 2 × 1.5 degrees (265 × 200 pc) of the Galaxy at 3-8 μm. These data represent the highest spatial resolution and sensitivity large-scale map made to date of the Galactic Center (GC) at mid-infrared wavelengths. The IRAC data provide a census of the optically obscured stellar sources as well as a detailed map of the highly filamentary structure in the interstellar medium. The diffuse emission is dominated by PAH emission from small grains in star-forming regions. Dark clouds displaying a large variety of sizes and morphologies are imaged, many of which remain opaque at IRAC wavelengths. Using a multiwavelength comparison, we determine which objects are likely to be in the foreground and which are located at the GC. We find no counterparts at IRAC wavelengths to the unique system of linear, nonthermal radio filaments present at the GC

The mid-infrared colors of the interstellar medium and extended sources at the Galactic center

A mid-infrared (3.6–8 μm) survey of the Galactic center has been carried out with the IRAC instrument on the Spitzer Space Telescope. This survey covers the central 2º x 1.4º (~280 x 200 pc) of the Galaxy. At 3.6 and 4.5 μm the emission is dominated by stellar sources, the fainter ones merging into an unresolved background. At 5.8 and 8 μm the stellar sources are fainter, and large-scale diffuse emission from the ISM of the Galaxy's central molecular zone becomes prominent. The survey reveals that the 8-to-5.8 μm color of the ISM emission is highly uniform across the surveyed region. This uniform color is consistent with a flat extinction law and emission from polycyclic aromatic hydrocarbons (PAHs). Models indicate that this broadband color should not be expected to change if the incident radiation field heating the dust and PAHs is ~10^4 times that of the solar neighborhood. Other regions of very red emission indicate cases where thick dust clouds obscure deeply embedded objects or very early stages of star formation

SCUBA Observations of the Host Galaxies of Gamma-Ray Bursts

In recent years, a population of galaxies with huge infrared luminosities and dust masses has been discovered in the submillimetre. Observations suggest that the AGN contribution to the luminosities of these submillimetre-selected galaxies is low; instead their luminosities are thought to be mainly due to strong episodes of star formation following merger events. Our current understanding of GRBs as the endpoints in the life of massive stars suggest that they will be located in such galaxies.We have observed a sample of well-located GRB host galaxies in the submillimetre. Comparing the results with the general submillimetre-selected galaxy population, we find that at low fluxes (S850 ≤ 4 mJy), the two agree well. However, there is a lack of bright GRB hosts in the submillimetre. This finding is reinforced when the results of other groups are included. Possible explanations are discussed. These results help us assess the roles of both GRB host galaxies and submillimetre-selected galaxies in the evolution of the Universe

Mannose binding lectin is required for alphavirus-induced arthritis/myositis

Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within the muscle and joints, and prior studies have demonstrated that the host complement system contributes to development of disease. In this study, we have used a mouse model of RRV-induced disease to identify and characterize which complement activation pathways mediate disease progression after infection, and we have identified the mannose binding lectin (MBL) pathway, but not the classical or alternative complement activation pathways, as essential for development of RRV-induced disease. MBL deposition was enhanced in RRV infected muscle tissue from wild type mice and RRV infected MBL deficient mice exhibited reduced disease, tissue damage, and complement deposition compared to wild-type mice. In contrast, mice deficient for key components of the classical or alternative complement activation pathways still developed severe RRV-induced disease. Further characterization of MBL deficient mice demonstrated that similar to C3(-/-) mice, viral replication and inflammatory cell recruitment were equivalent to wild type animals, suggesting that RRV-mediated induction of complement dependent immune pathology is largely MBL dependent. Consistent with these findings, human patients diagnosed with RRV disease had elevated serum MBL levels compared to healthy controls, and MBL levels in the serum and synovial fluid correlated with severity of disease. These findings demonstrate a role for MBL in promoting RRV-induced disease in both mice and humans and suggest that the MBL pathway of complement activation may be an effective target for therapeutic intervention for humans suffering from RRV-induced arthritis and myositis.This work was supported by NIH/NIAMS R01 AR 047190 awarded to MTH

Gas Accretion by Star Clusters and the Formation of Ultraluminous X-ray Sources from Cusps of Compact Remnants

Here we show that the overabundance of ultra-luminous, compact X-ray sources (ULXs) associated with moderately young clusters in interacting galaxies such as the Antennae and Cartwheel can be given an alternative explanation that does not involve the presence of intermediate mass black holes (IMBHs). We argue that gas density within these systems is enhanced by the collective potential of the cluster prior to being accreted onto the individual cluster members and, as a result, the aggregate X-ray luminosity arising from the neutron star cluster members can exceed $>10^{39} {\rm erg s^{-1}}$. Various observational tests to distinguish between IMBHs and accreting neutron star cusps are discussed.Comment: 4 pages, 3 figures, accepted to ApJ

Symmetry breaking due to Dzyaloshinsky-Moriya interactions in the kagome lattice

Due to the particular geometry of the kagom\'e lattice, it is shown that antisymmetric Dzyaloshinsky-Moriya interactions are allowed and induce magnetic ordering. The symmetry of the obtained low temperature magnetic phases are studied through mean field approximation and classical Mont\'e Carlo simulations. A phase diagram relating the geometry of the interaction and the ordering temperature has been derived. The order of magnitude of the anisotropies due to Dzyaloshinsky-Moriya interactions are more important than in non-frustrated magnets, which enhances its appearance in real systems. Application to the jarosites compounds is proposed. In particular, the low temperature behaviors of the Fe and Cr-based jarosites are correctly described by this model.Comment: 6 (revtex4) twocolumn pages, 6 .eps figures. Submitted to Phys. Rev.

Recognition of cancer warning signs and anticipated time to help-seeking in a population sample of adults in the UK

Background: Not recognising a symptom as suspicious is a common reason given by cancer patients for delayed help-seeking; but inevitably this is retrospective. We therefore investigated associations between recognition of warning signs for breast, colorectal and lung cancer and anticipated time to help-seeking for symptoms of each cancer. Methods: Computer-assisted telephone interviews were conducted with a population-representative sample (N=6965) of UK adults age greater than or equal to50 years, using the Awareness and Beliefs about Cancer scale. Anticipated time to help-seeking for persistent cough, rectal bleeding and breast changes was categorised as >2 vs less than or equal to2 weeks. Recognition of persistent cough, unexplained bleeding and unexplained lump as cancer warning signs was assessed (yes/no). Associations between recognition and help-seeking were examined for each symptom controlling for demographics and perceived ease of health-care access. Results: For each symptom, the odds of waiting for >2 weeks were significantly increased in those who did not recognise the related warning sign: breast changes: OR=2.45, 95% CI 1.47–4.08; rectal bleeding: OR=1.77, 1.36–2.30; persistent cough: OR=1.30, 1.17–1.46, independent of demographics and health-care access. Conclusion: Recognition of warning signs was associated with anticipating faster help-seeking for potential symptoms of cancer. Strategies to improve recognition are likely to facilitate earlier diagnosis