37 research outputs found
Sr. Jay: Social Justice
I interviewed Sr. Jay in January 2019 regarding her path to becoming a woman religious, and her experiences within her chosen order. This segment of the paper details her orderâs partaking in social justice oriented activities, and how that connected to course content
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The LGBT Community and Immigration in the U.S.
The issue brief describes the intersection between the LGBT community and immigration in the United States. It explains the ways in which LGBT individuals can seek asylum in the U.S. and how successful immigration laws have been in promoting the rights of the LGBT community
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Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions.
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of administration, little is known about their effects on the endometrial transcriptome in the presence or absence of estrogen. Herein, we assessed the transcriptome and pathways induced by progesterone (P4) and the three most commonly used synthetic progestins, medroxyprogesterone acetate (MPA), levonorgestrel (LNG), and norethindrone acetate (NETA), on human endometrial stromal fibroblasts (eSF), key players in endometrial physiology and reproductive success. While there were similar transcriptional responses, each progestin induced unique genes and biofunctions, consistent with their structural similarities to progesterone (P4 and MPA) or testosterone (LNG and NETA), involving cellular proliferation, migration and invasion. Addition of estradiol (E2) to each progestin influenced the number of differentially expressed genes and biofunctions in P4 and MPA, while LNG and NETA signatures were more independent of E2. Together, these data suggest different mechanisms of action for different progestins, with progestin-specific altered signatures when combined with E2. Further investigation is warranted for a personalized approach in different gynecologic disorders, for contraception, and minimizing side effects associated with their use
A Study of Direct Author Subvention for Publishing Humanities Books at Two Universities: A Report to the Andrew W. Mellon Foundation by Indiana University and University of Michigan
This report was produced as the main deliverable from the Andrew W. Mellon Foundation Grant 41400692, âA Study of Direct Author Subvention for Publishing Humanities Books at Two Universities.â The Indiana University team led by PI Carolyn Walters, consisted of Jason Baird Jackson, Scott Smart, Nick Fitzgerald, Gary Dunham and Shayna Pekala. The University of Michigan team led by PI James Hilton consisted of Paul Courant, Sidonie Smith, Meredith Kahn, Charles Watkinson, Jim Ottaviani, and Aaron McCollough. Lead authorship of the different sections in this report is indicated in the opening paragraphs. Supplemental data to this report is available at http://hdl.handle.net/2022/20358.This white paper presents recommendations about how a system of monographic publication fully funded by subventions from authorsâ parent institutions might function, based on research activities supported by the Andrew W. Mellon Foundation at Indiana University and the University of Michigan. While the contributors present a strong argument for implementing such an âauthor subventionâ system, they describe a number of challenges and potential unintended consequences. Particular issues discussed include how to determine which publishers would be eligible for support, how best to support untenured faculty, and how to avoid disenfranchising scholars at less well-funded institutions.Andrew W. Mellon Foundatio
Converging on bladder health through design thinking: From an ecology of influence to a focused set of research questions
Lower urinary tract symptoms affect a substantial number of women in the United States (U.S.) and globally. In 2015, the Prevention of Lower Urinary tract Symptoms in women (PLUS) Research Consortium was funded to establish the scientific basis for prevention efforts by (1) understanding healthy bladder function and (2) identifying risk and protective factors for bladder health in women across the lifecourse. This transdisciplinary consortium generated a list of over 600 candidate risk and protective factors for bladder health in women and girls and refined and prioritized these into 29 focused research questions to inform a national longitudinal observational study in the U.S. This paper describes that process using design thinking, a human-centered set of principles and strategies by which innovations are developed, as a framework. Design thinking is an iterative process consisting of five stages: Empathizing with end-users of innovations, Defining core principles girding the work, Ideation of all possible solutions, and rapid-cycle Prototyping and Testing of solutions. Lessons learned are offered to inform future prevention science research endeavors that might benefit from such an approach
Early Clinical Experiences for Second-Year Student Pharmacists at an Academic Medical Center
Objective. To examine student outcomes associated with the Student Medication and Reconciliation Team (SMART) program, which was designed to provide second-year student pharmacists at the University of North Carolina (UNC) Eshelman School of Pharmacy direct patient care experience at UNC Medical Center
Total Daily Pill Burden in HIV-Infected Patients in the Southern United States
The need for antiretroviral therapy coupled with treatment of chronic co-morbidities places HIV-infected patients at risk for polypharmacy. However, few studies have described overall pill burden among HIV-infected patients. HIV-infected outpatients of the UNC Infectious Diseases Clinic were enrolled in this cross-sectional study. Subjects were contacted prior to a scheduled appointment and asked to bring all their medications to the visit. Daily total pill burden and medication type were recorded. 151 subjects were recruited: 76% male, 58% African American, 97% receiving antiretrovirals (ARVs). Median age was 48 (IRQ: 42â54) years. The median number of medications per subject was 8 (IQR: 6â11), and the median individual daily pill burden was 8 pills (IQR: 5â15): 3 pills (range: 2â5) for ARVs and 6 (range: 3â12.5) pills for non-ARVs. Duration of ART (per 2 years increase) and more than 3 co-morbidities was significantly associated with high pill burden (over 10 pills per day) with adjusted OR of 2.09 (95% CI, 1.14â3.84) and 8.04 (95% CI, 2.30â28.15), respectively. As patients with HIV age, strategies to reduce pill burden and number of medications will become increasingly critical to maintaining adherence, preventing medication errors, and serious drugâdrug interactions
The Lantern, 2020-2021
One Thousand and One is Never Enough âą House on Hazel Ave. âą Crooked Men at Crooked Alley âą Home âą Honeybee âą The Witch\u27s Daughter âą Traveling to Reyu âą December 31st, 2019 âą The Dominator Rolls the Dice Again âą Red Flowers âą Military Ball âą Drowning in Color âą Early Bird âą Introspection âą Hot Water âą Reaching Into Space âą Floating Marigolds Before COVID-19 âą Smokestack 4 âą Longing âą His Fifth Year on Amstel Road âą Wonderful Moments âą Clean Glass âą Betty, the Debutante âą Teakettles Have it Easy âą Fuimos, Somos y Seramos Parte de la Historia de la Isla âą Kitchen Table âą She Couldn\u27t âą Cooling Down âą Not so Precious Stones âą Domestic Wild âą Violet Eater âą I Will be Sweet âą Flavor of Life âą Clogged Artery âą All Twenty-Six âą The Greatest âą From Ashes of War to Golden Cities âą A Good Thing âą Introduction âą Devotion âą Life of the Gambler âą Impressions: Or a Dining Table\u27s Soliloquy âą Looking Glass âą Montgomery Pie âą Under the Hill âą Paperback Lesbian âą Girl With Pearl Earring âą Your Mirror âą Jacket âą Illusions âą Strawberry Girl (Raw Sugar, Shattered Glass) âą I Don\u27t Jam With Instagram âą The Morning After Saturday âą A Brisk Monday Morning âą Emergence âą Politeness and Pattern Recognition âą Douglas Adams\u27 Guide to Florida âą A Love Story With Femininity âą Roots âą Dysmorphia IIIhttps://digitalcommons.ursinus.edu/lantern/1189/thumbnail.jp
Pain Control in Breast Surgery: Survey of Current Practice and Recommendations for Optimizing ManagementâAmerican Society of Breast Surgeons Opioid/Pain Control Workgroup
Introduction: The opioid epidemic in the United States is a public health crisis. Breast surgeons are obligated to provide good pain control for their patients after surgery but also must minimize administration of narcotics to prevent a surgical episode of care from becoming a patient's gateway into opioid dependence.
Methods: A survey to ascertain pain management practice patterns after breast surgery was performed. A review of currently available literature that was specific to breast surgery was performed to create recommendations regarding pain management strategies.
Results: A total of 609 surgeons completed the survey and demonstrated significant variations in pain management practices, specifically within regards to utilization of regional anesthesia (e.g., nerve blocks), and quantity of prescribed narcotics. There is excellent data to guide the use of local and regional anesthesia. There are, however, fewer studies to guide narcotic recommendations; thus, these recommendations were guided by prevailing practice patterns.
Conclusions: Pain management practices after breast surgery have significant variation and represent an opportunity to improve patient safety and quality of care. Multimodality approaches in conjunction with standardized quantities of narcotics are recommended
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead