Direct Dating Indicates a Mid-Holocene Age for Archaic Rock Engravings in Arid Central Australia

Archaic rock engravings are found widely across the arid interior of Australia and are thought to represent an early pan-continental tradition. A late Pleistocene age is assumed because of extensive weathering, but attempts to test this by direct dating have been unsuccessful. We use AMS 14C dating of calcium oxalate skins covering archaic engravings at two rock shelter sites in Central Australia (Wanga East and Puritjarra), constrained by 14C dates of charcoal in sedimentary layers beneath the same engraved slabs, to show this rock art is mid-Holocene in age. Despite a limited range of simple geometric designs and uniformity across the arid interior, this corpus of rock art is not associated with the initial peopling of the Australian desert, but is a later development reflecting the dynamics of established desert societies

Retrograde transport pathways utilised by viruses and protein toxins

A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera toxin, Shiga and Shiga-like toxins, Pseudomonas exotoxin A and ricin, and compare the retrograde routes followed by these protein toxins to those of the ER trafficking SV40 and polyoma viruses. We conclude that there is in fact no obligatory requirement for a glycolipid receptor, nor even with a protein receptor in a lipid-rich environment. Emerging data suggests instead that there is no common pathway utilised for retrograde transport by all of these pathogens, the choice of route being determined by the particular receptor utilised

Attitudes and factors involved in decision-making around complementary and alternative medicines (CAMs) by older Australians: A qualitative study

Introduction: Recent evidence has indicated that older Australians are increasingly turning to complementary and alternative medicines (CAMs) to address a variety of health issues. This qualitative study aimed to explore the attitudes and factors involved in decision-making around CAMs by older Australians upon the completion of a CAM educational intervention. Methods: Men and women aged over 65 years living in New South Wales, Australia were invited to participate in semi-structured interviews after taking part in a randomised control trial. Interviews were analysed using the framework approach. Results: A total of 20 participants aged over 65 years were interviewed. Themes captured the participants heightened awareness on their decision-making processes when choosing CAM, their increased sense of ability to make empowered and informed decisions regarding CAM, and pre-existing knowledge, or lack of, that impacted their ability to make decisions. Conclusions: The nature of health-related decision-making for older Australians around CAM is multifaceted and involves a consideration of their personal beliefs and experiences, social networks, education levels, healthcare professionals amongst other factors

The reverse shock of SNR1987A at 18 years after outburst

We use low-dispersion spectra obtained at the Magellan Observatory to study the broad H-alpha emission from the reverse shock of the infant supernova remnant SNR1987A. These spectra demonstrate that the spatio-kinematic structure of the reverse shock can be distinguished from that of the circumstellar ring and hotspots, even at ground-based spatial resolution. We measure a total dereddened H-alpha flux of 1.99(pm0.22)e-13 ergs/s/cm2 at an epoch 18.00 years after outburst. At 50 kpc, the total reverse shock luminosity in H-alpha is roughly 15 Lsun, which implies a total flux of neutral hydrogen atoms across the reverse shock of 8.9e46/s, or roughly 2.3e-3 Msun/yr. This represents an increase by a factor ~4 since 1997. Lyman continuum radiation from gas shocked by the forward blast wave can ionize neutral hydrogen atoms in the supernova debris before they reach the reverse shock. If the inward flux of ionizing photons exceeds the flux of hydrogen atoms approaching the reverse shock, this pre-ionization will shut off the broad Ly-alpha and H-alpha emission. The observed X-ray emission of SNR1987A implies that the ratio of ionizing flux to hydrogen atom flux across the reverse shock is presently at least 0.04. The X-ray emission is increasing much faster than the flux of atoms, and if these trends continue, we estimate that the broad Ly-alpha and H-alpha emission will vanish within about 7 years.Comment: 5 pgs, Fig 1 in color, accepted by ApJ Letter

Measuring and Narrowing the Compositionality Gap in Language Models

We investigate the ability of language models to perform compositional reasoning tasks where the overall solution depends on correctly composing the answers to sub-problems. We measure how often models can correctly answer all sub-problems but not generate the overall solution, a ratio we call the compositionality gap. We evaluate this ratio by asking multi-hop questions with answers that require composing multiple facts unlikely to have been observed together during pretraining. In the GPT-3 family of models, as model size increases we show that the single-hop question answering performance improves faster than the multi-hop performance does, therefore the compositionality gap does not decrease. This surprising result suggests that while more powerful models memorize and recall more factual knowledge, they show no corresponding improvement in their ability to perform this kind of compositional reasoning. We then demonstrate how elicitive prompting (such as chain of thought) narrows the compositionality gap by reasoning explicitly instead of implicitly. We present a new method, self-ask, that further improves on chain of thought. In our method, the model explicitly asks itself (and then answers) follow-up questions before answering the initial question. We finally show that self-ask's structured prompting lets us easily plug in a search engine to answer the follow-up questions, which additionally improves accuracy

An education intervention to improve decision making and health literacy among older Australians: A randomised controlled trial

Background: National policies seek to involve older Australian’s in decisions regarding their care; however, research has found varying levels of decision self-efficacy and health literacy skills. An increasing number of older Australians use complementary medicine (CM). We examined the effectiveness of a CM educational intervention delivered using a web or DVD plus booklet format to increase older adults’ decision self-efficacy and health literacy. Methods: A randomised controlled trial was conducted. We recruited individuals aged over 65years living in retirement villages or participating in community groups, in Sydney Australia. Participants were randomly allocated to receive a CM education intervention delivered using a website or DVD plus booklet versus booklet only. The primary outcome was decision self-efficacy. A secondary outcome included the Preparation for Decision-Making scale and health literacy. Outcomes were collected at 3 weeks, and 2 months from baseline, and analysed using an adjusted ANOVA, or repeated measures ANOVA. Result: We randomised 153 participants. Follow up at 3 weeks and 2 months was completed by 131 participants. There was a 14% (n =22) attrition rate. At the end of the intervention, we found no significant differences between groups for decision self-efficacy (mean difference (MD) 3.8, 95% confidence interval (CI) -2.0 to 9.6 p =0.20), there were no differences between groups on nine health literacy domains, and the Preparation for Decision-Making scale. Over 80% of participants in both groups rated the content as excellent or good. Conclusion: Decision self-efficacy improved for participants, but did not differ between groups. Decision self-efficacy and health literacy outcomes were not influenced by the delivery of education using a website, DVD or booklet. Participants found the resources useful, and rated the content as good or excellent. CM Web or DVD and booklet resources have the potential for wider application. Trial registration: The trial was registered with the Australian New Zealand Clinical Trials Registry: ACTRN (ACTRN12616000135415). The trial was registered on 5 February 2016

Simulation of greenhouse gases following land-use change to bioenergy crops using the ECOSSE model : a comparison between site measurements and model predictions

This work contributes to the ELUM (Ecosystem Land Use Modelling & Soil Carbon GHG Flux Trial) project, which was commissioned and funded by the Energy Technologies Institute (ETI). We acknowledge the E-OBS data set from the EU-FP6 project ENSEMBLES (http://ensembles-eu.metoffice.com) and the data providers in the ECA&D project (http://www.ecad.eu).Peer reviewedPublisher PD

Relaxation techniques for pain management in labour

Background: Many women would like to avoid pharmacological or invasive methods of pain management in labour and this may contribute to the popularity of complementary methods of pain management. This review examined currently available evidence on the use of relaxation therapies for pain management in labour. This is an update of a review first published in 2011. Objectives: To examine the effects of mind-body relaxation techniques for pain management in labour on maternal and neonatal well-being during and after labour. Search methods: We searched Cochrane Pregnancy and Childbirth’s Trials Register (9 May 2017), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 5 2017), MEDLINE (1966 to 24 May 2017), CINAHL (1980 to 24 May 2017), the Australian New Zealand Clinical Trials Registry (18 May 2017), ClinicalTrials.gov (18 May 2017), the ISRCTN Register (18 May 2017), the WHO International Clinical Trials Registry Platform (ICTRP) (18 May 2017), and reference lists of retrieved studies. Selection criteria: Randomised controlled trials (including quasi randomised and cluster trials) comparing relaxation methods with standard care, no treatment, other non-pharmacological forms of pain management in labour or placebo. Data collection and analysis: Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We attempted to contact study authors for additional information. We assessed evidence quality with GRADE methodology. Main results: This review update includes 19 studies (2519 women), 15 of which (1731 women) contribute data. Interventions examined included relaxation, yoga, music and mindfulness. Approximately half of the studies had a low risk of bias for random sequence generation and attrition bias. The majority of studies had a high risk of bias for performance and detection bias, and unclear risk of bias for, allocation concealment, reporting bias and other bias. We assessed the evidence from these studies as ranging from low to very low quality, and therefore the effects below should be interpreted with caution

The organisational and human resource challenges facing primary care trusts : protocol of a multiple case study

BACKGROUND: The study is designed to assess the organisational and human resource challenges faced by Primary Care Trusts (PCTs). Its objectives are to: specify the organisational and human resources challenges faced by PCTs in fulfilling the roles envisaged in government and local policy; examine how PCTs are addressing these challenges, in particular, to describe the organisational forms they have adopted, and the OD/HR strategies and initiatives they have planned or in place; assess how effective these structures, strategies and initiatives have been in enabling the PCTs to meet the organisational and human resources challenges they face; identify the factors, both internal to the PCT and in the wider health community, which have contributed to the success or failure of different structures, strategies and initiatives. METHODS: The study will be undertaken in three stages. In Stage 1 the key literature on public sector and NHS organisational development and human resources management will be reviewed, and discussions will be held with key researchers and policy makers working in this area. Stage 2 will focus on detailed case studies in six PCTs designed to examine the organisational and human resources challenges they face. Data will be collected using semi-structured interviews, group discussion, site visits, observation of key meetings and examination of local documentation. The findings from the case study PCTs will be cross checked with a Reference Group of up to 20 other PCG/Ts, and key officers working in organisational development or primary care at local, regional and national level. In Stage 3 analysis of findings from the preparatory work, the case studies and the feedback from the Reference Group will be used to identify practical lessons for PCTs, key messages for policy makers, and contributions to further theoretical development