805 research outputs found

    First Molecular Evidence for Underestimated Biodiversity of Rhachotropis (Crustacea, Amphipoda), with Description of a New Species

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    The crustacean genus Rhachotropis has a worldwide distribution and amongst the largest bathymetric range known from any amphipod genus. DNA barcoding of new material from around New Zealand and the Ross Sea indicated depth-related biogeographic patterns. New Zealand Rhachotropis do not form a monophyletic clade. Species from bathyal depths on the Chatham Rise, east of New Zealand, show lower sequence divergence to bathyal species from California and the Arctic than to abyssal New Zealand species. Species sampled in the Kermadec Trench, north of New Zealand below 5000 m, seem to be more closely related to Ross Sea abyssal species than to the New Zealand shelf species. The worldwide geographic and bathymetric distribution for all Rhachotropis species is presented here. Depth may have a greater influence on phylogeny than geographic distance. Molecular and morphological investigations of Rhachotropis specimens from the Chatham Rise, New Zealand revealed a species new to science which is described in detail, including scanning electron microscopy. This increases the number of described species of Rhachotropis to 60 worldwide

    Energy poverty policies: reviewing the policy design

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    Energy poverty is a complex, multidimensional and context-based challenge. Thus, policy approaches need to be comprehensive and coherent with the other public policies. To achieve this, multidisciplinary and multi-stakeholder bodies, dedicated to designing energy poverty policies and measures, should be established at the national and local levels in particular. In parallel, the adverse impacts of various other policies (fiscal, labour, climate, housing, energy, etc.) on energy poverty need to be assessed and steps taken to minimize or eliminate them. Critically, energy poverty policies must be designed through participatory processes, involving the people affected.info:eu-repo/semantics/publishedVersio

    Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction

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    BACKGROUND: Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin angiotensin system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy when administered via osmotic minipump in mice. Here, we investigate whether gene transfer of Ang-(1-9) is cardioprotective in a murine model of myocardial infarction (MI). OBJECTIVES: To evaluate effects of Ang-(1-9) gene therapy on myocardial structural and functional remodeling post infarction. METHODS: C57BL/6 mice underwent permanent left anterior descending coronary artery ligation and cardiac function was assessed using echocardiography for 8 weeks followed by a terminal measurement of left ventricular (LV) pressure-volume loops. Ang-(1-9) was delivered by adeno-associated viral vector via single tail vein injection immediately following induction of MI. Direct effects of Ang-(1-9) on cardiomyocyte excitation–contraction coupling and cardiac contraction were evaluated in isolated mouse and human cardiomyocytes and in an ex vivo Langendorff perfused whole heart model. RESULTS: Gene delivery of Ang-(1-9) significantly reduced sudden cardiac death post-MI. Pressure–volume measurements revealed complete restoration of end systolic pressure, ejection fraction, end systolic volume and the end diastolic pressure–volume relationship by Ang-(1-9) treatment. Stroke volume and cardiac output were significantly increased versus sham. Histological analysis revealed only mild effects on cardiac hypertrophy and fibrosis, but a significant increase in scar thickness. Direct assessment of Ang-(1-9) on isolated cardiomyocytes demonstrated a positive inotropic effect via increasing calcium transient amplitude and increasing contractility. Ang-(1-9) increased contraction in the Langendorff model through a protein kinase A-dependent mechanism. CONCLUSIONS: Our novel findings show that Ang-(1-9) gene therapy preserves LV systolic function post-MI, restoring cardiac function. Furthermore, Ang-(1-9) has a direct effect on cardiomyocyte 3 calcium handling through a protein kinase A-dependent mechanism. These data highlight Ang-(1-9) gene therapy as a potential new strategy in the context of MI

    Building community resilience in a context of climate change : The role of social capital

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    Acknowledgements This research was funded by the UK Research and INNOVATION Economic and Social Research Council award number ES/J500136/1.Peer reviewedPublisher PD

    Nonequilibrium and Nonlinear Dynamics in Geomaterials I : The Low Strain Regime

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    Members of a wide class of geomaterials are known to display complex and fascinating nonlinear and nonequilibrium dynamical behaviors over a wide range of bulk strains, down to surprisingly low values, e.g., 10^{-7}. In this paper we investigate two sandstones, Berea and Fontainebleau, and characterize their behavior under the influence of very small external forces via carefully controlled resonant bar experiments. By reducing environmental effects due to temperature and humidity variations, we are able to systematically and reproducibly study dynamical behavior at strains as low as 10^{-9}. Our study establishes the existence of two strain thresholds, the first, epsilon_L, below which the material is essentially linear, and the second, epsilon_M, below which the material is nonlinear but where quasiequilibrium thermodynamics still applies as evidenced by the success of Landau theory and a simple macroscopic description based on the Duffing oscillator. At strains above epsilon_M the behavior becomes truly nonequilibrium -- as demonstrated by the existence of material conditioning -- and Landau theory no longer applies. The main focus of this paper is the study of the region below the second threshold, but we also comment on how our work clarifies and resolves previous experimental conflicts, as well as suggest new directions of research.Comment: 14 pages, 15 figure

    Lehrveranstaltungen in Baudynamik und Erdbebeningenieurwesen an der EPFL

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    Baudynamik und Erdbebeningenieurwesen sind im Lehrplan des Bauingenieurwesens an der EPFL gut verankert. Baudynamik ist eine von nur fünf Pflichtveranstaltungen im Masterstudiengang und der Vorlesung muss daher von allen Studenten besucht und bestanden werden. Die Grundlagen der Erdbebenbemessung und –beurteilung von Gebäuden werden im Wahlfach „Seismic engineering“ vermittelt, welches im ersten Jahr des Masterstudiengangs angeboten wird. Seit dem vergangenen Jahr wird das Angebot in diesem Themenbereich von zwei weiteren Lehrveranstaltungen ergänzt: Die Vorlesung „Advanced steel design“ behandelt die Erdbebenbemessung von Stahlgebäuden und die Vorlesung „Nonlinear analysis of structures“ gibt eine grundlegende Einführung in die nichtlineare Berechnung von Gebäuden unter Erdbebeneinwirkung. Dieser Beitrag fasst die Zielsetzungen und Methoden der verschiedenen Vorlesungen kurz zusammen und zeigt einige der Modelle, die verwendet werden, um gewisse Grundprinzipien zu erläutern. Weiter wird auf Semester- und Masterarbeiten eingegangen, die im Bereich Baudynamik und Erdbebeningenieurwesen angeboten werden und ein integraler Teil der Ausbildung sind. Der Artikel schliesst mit einem kurzen Überblick über das Weiterbildungsangebot in der Schweiz in diesem Bereich
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